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[Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome].
Zhonghua Fu Chan Ke Za Zhi 2018; 53(1):18-22ZF

Abstract

Objective:

To compare the difference in risks of obstetric complications of singleton pregnancy between women with hyperandrogenic polycystic ovary syndrome (PCOS) and women with normoandrogenic PCOS.

Methods:

Prospective cohort study. This study was a secondary analysis of data collected during a multicenter randomized controlled clinical trial. Women who got clinical singleton pregnancy were grouped according to whether they were diagnosed with hyperandrogenism at baseline. There were 118 women with hyperandrogenism and 366 women without hyperandrogenism. The incidences of obstetric complications and birth weight were compared between the two groups.

Results:

Women with hyperandrogenic PCOS had a significantly higher risk of preterm delivery than women with normoandrogenic PCOS [12.7% (15/118) versus 3.6% (13/366); OR=3.94, 95%CI: 1.82-8.56]. After adjustment of age, duration of infertility, body mass index, and fresh or frozen embryo transfer group, hyperandrogenism was still associated with an increased risk of preterm delivery (OR=3.67, 95%CI: 1.67-8.07). Compared with women with normoandrogenic PCOS, women with hyperandrogenic PCOS had similar risks of pregnancy loss, gestational diabetes mellitus, pre-eclampsia, placenta previa, and postpartum hemorrhage (all P>0.05). Birth weight as well as the risks of being small for gestational age and large for gestational age were also comparable between the two groups (all P>0.05).

Conclusion:

In women with PCOS and singleton pregnancy, those with preconceptional hyperandrogenism have a higher risk of preterm delivery than those without hyperandrogenism.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Wei DM
    Reproductive Endocrinology Department, The Center for Reproductive Medicine, Shandong University, Jinan 250021, China.
    Zhang ZZ
    No affiliation info available
    Wang Z
    No affiliation info available
    Li P
    No affiliation info available
    Wang JF
    No affiliation info available
    Liu YJ
    No affiliation info available
    Zhang JT
    No affiliation info available
    Shi YH
    No affiliation info available

    MeSH

    Abortion, SpontaneousBirth WeightBody Mass IndexDiabetes, GestationalFemaleFertilization in VitroGestational AgeHumansHyperandrogenismInfant, NewbornInfant, Small for Gestational AgePolycystic Ovary SyndromePre-EclampsiaPregnancyPregnancy ComplicationsPremature BirthProspective Studies

    Pub Type(s)

    Journal Article
    Multicenter Study
    Randomized Controlled Trial

    Language

    chi

    PubMed ID

    29374881

    Citation

    Wei, D M., et al. "[Effect of Hyperandrogenism On Obstetric Complications of Singleton Pregnancy From in Vitro Fertilization in Women With Polycystic Ovary Syndrome]." Zhonghua Fu Chan Ke Za Zhi, vol. 53, no. 1, 2018, pp. 18-22.
    Wei DM, Zhang ZZ, Wang Z, et al. [Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome]. Zhonghua Fu Chan Ke Za Zhi. 2018;53(1):18-22.
    Wei, D. M., Zhang, Z. Z., Wang, Z., Li, P., Wang, J. F., Liu, Y. J., ... Shi, Y. H. (2018). [Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome]. Zhonghua Fu Chan Ke Za Zhi, 53(1), pp. 18-22. doi:10.3760/cma.j.issn.0529-567X.2018.01.005.
    Wei DM, et al. [Effect of Hyperandrogenism On Obstetric Complications of Singleton Pregnancy From in Vitro Fertilization in Women With Polycystic Ovary Syndrome]. Zhonghua Fu Chan Ke Za Zhi. 2018 Jan 25;53(1):18-22. PubMed PMID: 29374881.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome]. AU - Wei,D M, AU - Zhang,Z Z, AU - Wang,Z, AU - Li,P, AU - Wang,J F, AU - Liu,Y J, AU - Zhang,J T, AU - Shi,Y H, PY - 2018/1/29/entrez PY - 2018/1/30/pubmed PY - 2018/2/16/medline KW - Hyperandrogenism KW - Polycystic ovary syndrome KW - Pregnancy complications KW - Premature birth SP - 18 EP - 22 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 53 IS - 1 N2 - Objective: To compare the difference in risks of obstetric complications of singleton pregnancy between women with hyperandrogenic polycystic ovary syndrome (PCOS) and women with normoandrogenic PCOS. Methods: Prospective cohort study. This study was a secondary analysis of data collected during a multicenter randomized controlled clinical trial. Women who got clinical singleton pregnancy were grouped according to whether they were diagnosed with hyperandrogenism at baseline. There were 118 women with hyperandrogenism and 366 women without hyperandrogenism. The incidences of obstetric complications and birth weight were compared between the two groups. Results: Women with hyperandrogenic PCOS had a significantly higher risk of preterm delivery than women with normoandrogenic PCOS [12.7% (15/118) versus 3.6% (13/366); OR=3.94, 95%CI: 1.82-8.56]. After adjustment of age, duration of infertility, body mass index, and fresh or frozen embryo transfer group, hyperandrogenism was still associated with an increased risk of preterm delivery (OR=3.67, 95%CI: 1.67-8.07). Compared with women with normoandrogenic PCOS, women with hyperandrogenic PCOS had similar risks of pregnancy loss, gestational diabetes mellitus, pre-eclampsia, placenta previa, and postpartum hemorrhage (all P>0.05). Birth weight as well as the risks of being small for gestational age and large for gestational age were also comparable between the two groups (all P>0.05). Conclusion: In women with PCOS and singleton pregnancy, those with preconceptional hyperandrogenism have a higher risk of preterm delivery than those without hyperandrogenism. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/29374881/[Effect_of_hyperandrogenism_on_obstetric_complications_of_singleton_pregnancy_from_in_vitro_fertilization_in_women_with_polycystic_ovary_syndrome]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0529-567X&year=2018&vol=53&issue=1&fpage=18 DB - PRIME DP - Unbound Medicine ER -