[Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome].Zhonghua Fu Chan Ke Za Zhi. 2018 Jan 25; 53(1):18-22.ZF
Abstract
Objective:
To compare the difference in risks of obstetric complications of singleton pregnancy between women with hyperandrogenic polycystic ovary syndrome (PCOS) and women with normoandrogenic PCOS.Methods:
Prospective cohort study. This study was a secondary analysis of data collected during a multicenter randomized controlled clinical trial. Women who got clinical singleton pregnancy were grouped according to whether they were diagnosed with hyperandrogenism at baseline. There were 118 women with hyperandrogenism and 366 women without hyperandrogenism. The incidences of obstetric complications and birth weight were compared between the two groups.Results:
Women with hyperandrogenic PCOS had a significantly higher risk of preterm delivery than women with normoandrogenic PCOS [12.7% (15/118) versus 3.6% (13/366); OR=3.94, 95%CI: 1.82-8.56]. After adjustment of age, duration of infertility, body mass index, and fresh or frozen embryo transfer group, hyperandrogenism was still associated with an increased risk of preterm delivery (OR=3.67, 95%CI: 1.67-8.07). Compared with women with normoandrogenic PCOS, women with hyperandrogenic PCOS had similar risks of pregnancy loss, gestational diabetes mellitus, pre-eclampsia, placenta previa, and postpartum hemorrhage (all P>0.05). Birth weight as well as the risks of being small for gestational age and large for gestational age were also comparable between the two groups (all P>0.05).Conclusion:
In women with PCOS and singleton pregnancy, those with preconceptional hyperandrogenism have a higher risk of preterm delivery than those without hyperandrogenism.Links
MeSH
Pub Type(s)
Journal Article
Multicenter Study
Randomized Controlled Trial
Language
chi
PubMed ID
29374881
Citation
Wei, D M., et al. "[Effect of Hyperandrogenism On Obstetric Complications of Singleton Pregnancy From in Vitro Fertilization in Women With Polycystic Ovary Syndrome]." Zhonghua Fu Chan Ke Za Zhi, vol. 53, no. 1, 2018, pp. 18-22.
Wei DM, Zhang ZZ, Wang Z, et al. [Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome]. Zhonghua Fu Chan Ke Za Zhi. 2018;53(1):18-22.
Wei, D. M., Zhang, Z. Z., Wang, Z., Li, P., Wang, J. F., Liu, Y. J., Zhang, J. T., & Shi, Y. H. (2018). [Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome]. Zhonghua Fu Chan Ke Za Zhi, 53(1), 18-22. https://doi.org/10.3760/cma.j.issn.0529-567X.2018.01.005
Wei DM, et al. [Effect of Hyperandrogenism On Obstetric Complications of Singleton Pregnancy From in Vitro Fertilization in Women With Polycystic Ovary Syndrome]. Zhonghua Fu Chan Ke Za Zhi. 2018 Jan 25;53(1):18-22. PubMed PMID: 29374881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - [Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome].
AU - Wei,D M,
AU - Zhang,Z Z,
AU - Wang,Z,
AU - Li,P,
AU - Wang,J F,
AU - Liu,Y J,
AU - Zhang,J T,
AU - Shi,Y H,
PY - 2018/1/29/entrez
PY - 2018/1/30/pubmed
PY - 2018/2/16/medline
KW - Hyperandrogenism
KW - Polycystic ovary syndrome
KW - Pregnancy complications
KW - Premature birth
SP - 18
EP - 22
JF - Zhonghua fu chan ke za zhi
JO - Zhonghua Fu Chan Ke Za Zhi
VL - 53
IS - 1
N2 - Objective: To compare the difference in risks of obstetric complications of singleton pregnancy between women with hyperandrogenic polycystic ovary syndrome (PCOS) and women with normoandrogenic PCOS. Methods: Prospective cohort study. This study was a secondary analysis of data collected during a multicenter randomized controlled clinical trial. Women who got clinical singleton pregnancy were grouped according to whether they were diagnosed with hyperandrogenism at baseline. There were 118 women with hyperandrogenism and 366 women without hyperandrogenism. The incidences of obstetric complications and birth weight were compared between the two groups. Results: Women with hyperandrogenic PCOS had a significantly higher risk of preterm delivery than women with normoandrogenic PCOS [12.7% (15/118) versus 3.6% (13/366); OR=3.94, 95%CI: 1.82-8.56]. After adjustment of age, duration of infertility, body mass index, and fresh or frozen embryo transfer group, hyperandrogenism was still associated with an increased risk of preterm delivery (OR=3.67, 95%CI: 1.67-8.07). Compared with women with normoandrogenic PCOS, women with hyperandrogenic PCOS had similar risks of pregnancy loss, gestational diabetes mellitus, pre-eclampsia, placenta previa, and postpartum hemorrhage (all P>0.05). Birth weight as well as the risks of being small for gestational age and large for gestational age were also comparable between the two groups (all P>0.05). Conclusion: In women with PCOS and singleton pregnancy, those with preconceptional hyperandrogenism have a higher risk of preterm delivery than those without hyperandrogenism.
SN - 0529-567X
UR - https://www.unboundmedicine.com/medline/citation/29374881/[Effect_of_hyperandrogenism_on_obstetric_complications_of_singleton_pregnancy_from_in_vitro_fertilization_in_women_with_polycystic_ovary_syndrome]_
L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0529-567X&year=2018&vol=53&issue=1&fpage=18
DB - PRIME
DP - Unbound Medicine
ER -