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Default Mode Network Aberrant Connectivity Associated with Neurological Soft Signs in Schizophrenia Patients and Unaffected Relatives.
Front Psychiatry 2017; 8:298FP

Abstract

Brain connectivity and neurological soft signs (NSS) are reportedly abnormal in schizophrenia and unaffected relatives, suggesting they might be useful neurobiological markers of the illness. NSS are discrete sensorimotor impairments thought to correspond to deviant brain development. Although NSS support the hypothesis that schizophrenia involves disruption in functional circuits involving several hetero modal association areas, little is known about the relationship between NSS and brain connectivity. We explored functional connectivity abnormalities of the default mode network (DMN) related to NSS in schizophrenia. A cross-sectional study was performed with 27 patients diagnosed with schizophrenia, 23 unaffected relatives who were unrelated to the schizophrenia subjects included in the study, and 35 healthy controls. Subjects underwent magnetic resonance imaging scans including a functional resting-state acquisition and NSS evaluation. Seed-to-voxel and independent component analyses were used to study brain connectivity. NSS scores were significantly different between groups, ranging from a higher to lower scores for patients, unaffected relatives, and healthy controls, respectively (analysis of variance effect of group F = 56.51, p < 0.001). The connectivity analysis revealed significant hyperconnectivity in the fusiform gyrus, insular and dorsolateral prefrontal cortices, inferior and middle frontal gyri, middle and superior temporal gyri, and posterior cingulate cortex [minimum p-family wise error (FWE) < 0.05 for all clusters] in patients with schizophrenia as compared with in controls. Also, unaffected relatives showed hyperconnectivity in relation to controls in the supramarginal association and dorsal posterior cingulate cortices (p-FWE < 0.05 for all clusters) in patients with schizophrenia as compared with in controls. Also, unaffected relatives showed hyperconnectivity in relation to controls in the supramarginal association and dorsal posterior cingulate cortices (p-FWE = 0.001) and in the anterior prefrontal cortex (42 voxels, p-FWE = 0.047). A negative correlation was found between left caudate connectivity and NSS [p-FWE = 0.044, cluster size (k) = 110 voxels]. These findings support the theory of widespread abnormal connectivity in schizophrenia, reinforcing DMN hyperconnectivity and NSS as neurobiological markers of schizophrenia. The results also indicate the caudate nucleus as the gateway to the motor consequences of abnormal DMN connectivity.

Authors+Show Affiliations

Neuroimaging Research Group, Neuroscience, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain. Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.Neuroimaging Research Group, Neuroscience, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain. Cognitive Neuroscience Research Group, Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom. Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom. Institute of Behavioural and Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom.Neuroimaging Research Group, Neuroscience, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain. Cognitive Neuroscience Research Group, Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.Neuroimaging Research Group, Neuroscience, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain. Cognitive Neuroscience Research Group, Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.Neuroimaging Research Group, Neuroscience, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain. Cognitive Neuroscience Research Group, Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.Neuroimaging Research Group, Neuroscience, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain. Cognitive Neuroscience Research Group, Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29375404

Citation

Galindo, Liliana, et al. "Default Mode Network Aberrant Connectivity Associated With Neurological Soft Signs in Schizophrenia Patients and Unaffected Relatives." Frontiers in Psychiatry, vol. 8, 2017, p. 298.
Galindo L, Bergé D, Murray GK, et al. Default Mode Network Aberrant Connectivity Associated with Neurological Soft Signs in Schizophrenia Patients and Unaffected Relatives. Front Psychiatry. 2017;8:298.
Galindo, L., Bergé, D., Murray, G. K., Mané, A., Bulbena, A., Pérez, V., & Vilarroya, O. (2017). Default Mode Network Aberrant Connectivity Associated with Neurological Soft Signs in Schizophrenia Patients and Unaffected Relatives. Frontiers in Psychiatry, 8, p. 298. doi:10.3389/fpsyt.2017.00298.
Galindo L, et al. Default Mode Network Aberrant Connectivity Associated With Neurological Soft Signs in Schizophrenia Patients and Unaffected Relatives. Front Psychiatry. 2017;8:298. PubMed PMID: 29375404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Default Mode Network Aberrant Connectivity Associated with Neurological Soft Signs in Schizophrenia Patients and Unaffected Relatives. AU - Galindo,Liliana, AU - Bergé,Daniel, AU - Murray,Graham K, AU - Mané,Anna, AU - Bulbena,Antonio, AU - Pérez,Victor, AU - Vilarroya,Oscar, Y1 - 2018/01/08/ PY - 2017/10/15/received PY - 2017/12/13/accepted PY - 2018/1/30/entrez PY - 2018/1/30/pubmed PY - 2018/1/30/medline KW - connectivity KW - default mode network KW - endophenotype KW - neurological soft signs KW - schizophrenia SP - 298 EP - 298 JF - Frontiers in psychiatry JO - Front Psychiatry VL - 8 N2 - Brain connectivity and neurological soft signs (NSS) are reportedly abnormal in schizophrenia and unaffected relatives, suggesting they might be useful neurobiological markers of the illness. NSS are discrete sensorimotor impairments thought to correspond to deviant brain development. Although NSS support the hypothesis that schizophrenia involves disruption in functional circuits involving several hetero modal association areas, little is known about the relationship between NSS and brain connectivity. We explored functional connectivity abnormalities of the default mode network (DMN) related to NSS in schizophrenia. A cross-sectional study was performed with 27 patients diagnosed with schizophrenia, 23 unaffected relatives who were unrelated to the schizophrenia subjects included in the study, and 35 healthy controls. Subjects underwent magnetic resonance imaging scans including a functional resting-state acquisition and NSS evaluation. Seed-to-voxel and independent component analyses were used to study brain connectivity. NSS scores were significantly different between groups, ranging from a higher to lower scores for patients, unaffected relatives, and healthy controls, respectively (analysis of variance effect of group F = 56.51, p < 0.001). The connectivity analysis revealed significant hyperconnectivity in the fusiform gyrus, insular and dorsolateral prefrontal cortices, inferior and middle frontal gyri, middle and superior temporal gyri, and posterior cingulate cortex [minimum p-family wise error (FWE) < 0.05 for all clusters] in patients with schizophrenia as compared with in controls. Also, unaffected relatives showed hyperconnectivity in relation to controls in the supramarginal association and dorsal posterior cingulate cortices (p-FWE < 0.05 for all clusters) in patients with schizophrenia as compared with in controls. Also, unaffected relatives showed hyperconnectivity in relation to controls in the supramarginal association and dorsal posterior cingulate cortices (p-FWE = 0.001) and in the anterior prefrontal cortex (42 voxels, p-FWE = 0.047). A negative correlation was found between left caudate connectivity and NSS [p-FWE = 0.044, cluster size (k) = 110 voxels]. These findings support the theory of widespread abnormal connectivity in schizophrenia, reinforcing DMN hyperconnectivity and NSS as neurobiological markers of schizophrenia. The results also indicate the caudate nucleus as the gateway to the motor consequences of abnormal DMN connectivity. SN - 1664-0640 UR - https://www.unboundmedicine.com/medline/citation/29375404/Default_Mode_Network_Aberrant_Connectivity_Associated_with_Neurological_Soft_Signs_in_Schizophrenia_Patients_and_Unaffected_Relatives_ L2 - https://dx.doi.org/10.3389/fpsyt.2017.00298 DB - PRIME DP - Unbound Medicine ER -