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Differences in Prevalence of Muscle Weakness (Sarcopenia) in Haemodialysis Patients Determined by Hand Grip Strength Due to Variation in Guideline Definitions of Sarcopenia.
Nutr Clin Pract. 2018 Apr; 33(2):255-260.NC

Abstract

BACKGROUND

Muscle weakness is associated with increased mortality, and hemodialysis (HD) patients are at an increased risk for muscle loss. There is no agreed definition for muscle weakness, so we determined whether using different cut-off criteria recommended by guideline groups altered the prevalence in HD patients.

METHODS

We measured hand grip strength (HGS) in HD outpatients, comparing HGS with clinical guideline cut-offs (European Working Group on Sarcopenia in Older People [EWGSOP] and North American Foundation for the National Institutes of Health Sarcopenia Project [FNIH]) used to define muscle wasting (sarcopenia) with age-matched and gender-matched normative data.

RESULTS

We studied 459 patients, 61.4% male, 47.3% diabetic. The prevalence of muscle weakness was significantly different when measuring HGS; 84.5% using the EWGSOP cut-off and 73.2% with FNIH criteria, and 75.2% using North American normative data and 56.6% U.K. normative data (P < .01). On logistic regression, muscle weakness was associated with age (odds ratio [OR] 1.05, P < .001), weight (OR 0.96, P < .001), serum albumin (OR 0.89, P = .007), and being nondiabetic (OR 0.31, P = .001). Of patients with no comorbidity, 66.7% were weak when compared with 93.8% with the highest comorbidity scores (P < .001).

CONCLUSION

There is currently no agreed universal definition for sarcopenia, but the EWGSOP and FNIH advocate HGS cut-offs as part of their definition. The prevalence of muscle weakness varies according to cut-off and whether age-matched and gender-matched normative data are used. In addition, patient characteristics in terms of age and comorbidity determine the prevalence of muscle weakness.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Tangvoraphonkchai K
Department of Renal Medicine, Mahasarakham University Hospital, Mahasarakham, Thailand.
Hung R
University College London Centre for Nephrology, Royal Free Hospital, London, UK.
Sadeghi-Alavijeh O
University College London Centre for Nephrology, Royal Free Hospital, London, UK.
Davenport A
University College London Centre for Nephrology, Royal Free Hospital, London, UK.

MeSH

AgedAged, 80 and overCohort StudiesComorbidityCross-Sectional StudiesElder Nutritional Physiological PhenomenaFemaleGeriatric AssessmentHand StrengthHospitals, UniversityHumansLondonMaleMalnutritionMiddle AgedNutrition AssessmentOutpatient Clinics, HospitalPractice Guidelines as TopicPrevalenceRenal DialysisRenal Insufficiency, ChronicRetrospective StudiesSarcopeniaSeverity of Illness Index

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29377324

Citation

Tangvoraphonkchai, Kamonwan, et al. "Differences in Prevalence of Muscle Weakness (Sarcopenia) in Haemodialysis Patients Determined By Hand Grip Strength Due to Variation in Guideline Definitions of Sarcopenia." Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, vol. 33, no. 2, 2018, pp. 255-260.
Tangvoraphonkchai K, Hung R, Sadeghi-Alavijeh O, et al. Differences in Prevalence of Muscle Weakness (Sarcopenia) in Haemodialysis Patients Determined by Hand Grip Strength Due to Variation in Guideline Definitions of Sarcopenia. Nutr Clin Pract. 2018;33(2):255-260.
Tangvoraphonkchai, K., Hung, R., Sadeghi-Alavijeh, O., & Davenport, A. (2018). Differences in Prevalence of Muscle Weakness (Sarcopenia) in Haemodialysis Patients Determined by Hand Grip Strength Due to Variation in Guideline Definitions of Sarcopenia. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 33(2), 255-260. https://doi.org/10.1002/ncp.10003
Tangvoraphonkchai K, et al. Differences in Prevalence of Muscle Weakness (Sarcopenia) in Haemodialysis Patients Determined By Hand Grip Strength Due to Variation in Guideline Definitions of Sarcopenia. Nutr Clin Pract. 2018;33(2):255-260. PubMed PMID: 29377324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in Prevalence of Muscle Weakness (Sarcopenia) in Haemodialysis Patients Determined by Hand Grip Strength Due to Variation in Guideline Definitions of Sarcopenia. AU - Tangvoraphonkchai,Kamonwan, AU - Hung,Rachel, AU - Sadeghi-Alavijeh,Omid, AU - Davenport,Andrew, Y1 - 2018/01/26/ PY - 2017/07/21/received PY - 2017/09/05/revised PY - 2017/09/09/accepted PY - 2018/1/30/pubmed PY - 2018/9/22/medline PY - 2018/1/30/entrez KW - hand strength KW - muscle weakness KW - renal dialysis KW - sarcopenia nutrition assessment SP - 255 EP - 260 JF - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JO - Nutr Clin Pract VL - 33 IS - 2 N2 - BACKGROUND: Muscle weakness is associated with increased mortality, and hemodialysis (HD) patients are at an increased risk for muscle loss. There is no agreed definition for muscle weakness, so we determined whether using different cut-off criteria recommended by guideline groups altered the prevalence in HD patients. METHODS: We measured hand grip strength (HGS) in HD outpatients, comparing HGS with clinical guideline cut-offs (European Working Group on Sarcopenia in Older People [EWGSOP] and North American Foundation for the National Institutes of Health Sarcopenia Project [FNIH]) used to define muscle wasting (sarcopenia) with age-matched and gender-matched normative data. RESULTS: We studied 459 patients, 61.4% male, 47.3% diabetic. The prevalence of muscle weakness was significantly different when measuring HGS; 84.5% using the EWGSOP cut-off and 73.2% with FNIH criteria, and 75.2% using North American normative data and 56.6% U.K. normative data (P < .01). On logistic regression, muscle weakness was associated with age (odds ratio [OR] 1.05, P < .001), weight (OR 0.96, P < .001), serum albumin (OR 0.89, P = .007), and being nondiabetic (OR 0.31, P = .001). Of patients with no comorbidity, 66.7% were weak when compared with 93.8% with the highest comorbidity scores (P < .001). CONCLUSION: There is currently no agreed universal definition for sarcopenia, but the EWGSOP and FNIH advocate HGS cut-offs as part of their definition. The prevalence of muscle weakness varies according to cut-off and whether age-matched and gender-matched normative data are used. In addition, patient characteristics in terms of age and comorbidity determine the prevalence of muscle weakness. SN - 1941-2452 UR - https://www.unboundmedicine.com/medline/citation/29377324/Differences_in_Prevalence_of_Muscle_Weakness__Sarcopenia__in_Haemodialysis_Patients_Determined_by_Hand_Grip_Strength_Due_to_Variation_in_Guideline_Definitions_of_Sarcopenia_ DB - PRIME DP - Unbound Medicine ER -