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No Effects of Stimulating the Left Ventrolateral Prefrontal Cortex with tDCS on Verbal Working Memory Updating.
Front Neurosci 2017; 11:738FN

Abstract

The effects of transcranial direct current stimulation (tDCS) on dorsolateral prefrontal cortex functions, such as working memory (WM), have been examined in a number of studies. However, much less is known about the behavioral effects of tDCS over other important WM-related brain regions, such as the ventrolateral prefrontal cortex (VLPFC). In a counterbalanced within-subjects design with 33 young healthy participants, we examined whether online and offline single-session tDCS over VLPFC affects WM updating performance as measured by a digit 3-back task. We compared three conditions: anodal, cathodal and sham. We observed no significant tDCS effects on participants' accuracy or reaction times during or after the stimulation. Neither did we find any differences between anodal and cathodal stimulation. Largely similar results were obtained when comparing subgroups of high- and low-performing participants. Possible reasons for the lack of effects, including individual differences in responsiveness to tDCS, features of montage, task and sample characteristics, and the role of VLPFC in WM, are discussed.

Authors+Show Affiliations

Department of Psychology, Abo Akademi University, Turku, Finland.Department of Psychology, Abo Akademi University, Turku, Finland. Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.Department of Psychology, Abo Akademi University, Turku, Finland. Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Department of Psychology, University of Turku, Turku, Finland.Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States. Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States. Department of Neurology, University of Turku, Turku, Finland.Department of Psychology, Abo Akademi University, Turku, Finland. Turku Brain and Mind Center, University of Turku, Turku, Finland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29379410

Citation

Lukasik, Karolina M., et al. "No Effects of Stimulating the Left Ventrolateral Prefrontal Cortex With tDCS On Verbal Working Memory Updating." Frontiers in Neuroscience, vol. 11, 2017, p. 738.
Lukasik KM, Lehtonen M, Salmi J, et al. No Effects of Stimulating the Left Ventrolateral Prefrontal Cortex with tDCS on Verbal Working Memory Updating. Front Neurosci. 2017;11:738.
Lukasik, K. M., Lehtonen, M., Salmi, J., Meinzer, M., Joutsa, J., & Laine, M. (2017). No Effects of Stimulating the Left Ventrolateral Prefrontal Cortex with tDCS on Verbal Working Memory Updating. Frontiers in Neuroscience, 11, p. 738. doi:10.3389/fnins.2017.00738.
Lukasik KM, et al. No Effects of Stimulating the Left Ventrolateral Prefrontal Cortex With tDCS On Verbal Working Memory Updating. Front Neurosci. 2017;11:738. PubMed PMID: 29379410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No Effects of Stimulating the Left Ventrolateral Prefrontal Cortex with tDCS on Verbal Working Memory Updating. AU - Lukasik,Karolina M, AU - Lehtonen,Minna, AU - Salmi,Juha, AU - Meinzer,Marcus, AU - Joutsa,Juho, AU - Laine,Matti, Y1 - 2018/01/10/ PY - 2017/08/02/received PY - 2017/12/18/accepted PY - 2018/1/31/entrez PY - 2018/1/31/pubmed PY - 2018/1/31/medline KW - brain stimulation KW - n-back KW - tDCS KW - ventrolateral prefrontal cortex KW - verbal working memory SP - 738 EP - 738 JF - Frontiers in neuroscience JO - Front Neurosci VL - 11 N2 - The effects of transcranial direct current stimulation (tDCS) on dorsolateral prefrontal cortex functions, such as working memory (WM), have been examined in a number of studies. However, much less is known about the behavioral effects of tDCS over other important WM-related brain regions, such as the ventrolateral prefrontal cortex (VLPFC). In a counterbalanced within-subjects design with 33 young healthy participants, we examined whether online and offline single-session tDCS over VLPFC affects WM updating performance as measured by a digit 3-back task. We compared three conditions: anodal, cathodal and sham. We observed no significant tDCS effects on participants' accuracy or reaction times during or after the stimulation. Neither did we find any differences between anodal and cathodal stimulation. Largely similar results were obtained when comparing subgroups of high- and low-performing participants. Possible reasons for the lack of effects, including individual differences in responsiveness to tDCS, features of montage, task and sample characteristics, and the role of VLPFC in WM, are discussed. SN - 1662-4548 UR - https://www.unboundmedicine.com/medline/citation/29379410/No_Effects_of_Stimulating_the_Left_Ventrolateral_Prefrontal_Cortex_with_tDCS_on_Verbal_Working_Memory_Updating_ L2 - https://doi.org/10.3389/fnins.2017.00738 DB - PRIME DP - Unbound Medicine ER -