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The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials.
Medicine (Baltimore) 2018; 97(5):e9679M

Abstract

BACKGROUND

Probiotics supplements provide a new nonpharmacological alternative to reduce cardiovascular risk factors. The impact of probiotics on the reduction of total cholesterol (TC) remains controversial. We conducted a meta-analysis to showcase the most updated and comprehensive evaluation of the studies.

METHODS

Randomized controlled trials (RCTs) were searched from electronic databases, including PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang database dating from January 2007 to January 2017. The curative effects of probiotics on the reduction of TC were assessed using mean difference (MD), as well as their 95% confidence interval (CI). RevMan software (version 5.3) was used to carry out this meta-analysis.

RESULTS

Thirty-two RCTs including 1971 patients met the inclusion criteria. Results of this analysis showed that compared with the control group serum TC was significantly reduced in probiotics group [MD = -13.27, 95% CI (-16.74 to 9.80), P < .05]. In addition, specific strains also significantly reduced serum TC, L acidophilus and B lactis [MD = -8.30, 95% CI (-10.44, -6.15), P < .05]; VSL#3 [MD = -11.04, 95% CI (-19.61, -2.48), P < .05]; L plantarum t ≤ 6 weeks: [MD = -1.56, 95% CI (-6.97, -3.86), P < .05] or t > 6 weeks: [MD = -22.18, 95% CI (-28.73, -15.63), P < .05]. Subgroup analysis indicated that the difference of baseline TC, probiotics forms and intervention duration might have a significant impact on the results. However, strains and doses of probiotics had no significant influence on curative effects.

CONCLUSION

Available evidence indicates that probiotics supplements can significantly reduce serum TC. Furthermore, higher baseline TC, longer intervention time, and probiotics in capsules form might contribute to a better curative effect.

Authors+Show Affiliations

College of Nursing.School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine.School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine.Hospital of Ren Min, JiXian, Tianjin, China.School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine.College of Nursing.School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

29384846

Citation

Wang, Lang, et al. "The Effects of Probiotics On Total Cholesterol: a Meta-analysis of Randomized Controlled Trials." Medicine, vol. 97, no. 5, 2018, pp. e9679.
Wang L, Guo MJ, Gao Q, et al. The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2018;97(5):e9679.
Wang, L., Guo, M. J., Gao, Q., Yang, J. F., Yang, L., Pang, X. L., & Jiang, X. J. (2018). The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials. Medicine, 97(5), pp. e9679. doi:10.1097/MD.0000000000009679.
Wang L, et al. The Effects of Probiotics On Total Cholesterol: a Meta-analysis of Randomized Controlled Trials. Medicine (Baltimore). 2018;97(5):e9679. PubMed PMID: 29384846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials. AU - Wang,Lang, AU - Guo,Mao-Juan, AU - Gao,Qing, AU - Yang,Jin-Feng, AU - Yang,Lin, AU - Pang,Xiao-Li, AU - Jiang,Xi-Juan, PY - 2018/2/1/entrez PY - 2018/2/1/pubmed PY - 2018/2/14/medline SP - e9679 EP - e9679 JF - Medicine JO - Medicine (Baltimore) VL - 97 IS - 5 N2 - BACKGROUND: Probiotics supplements provide a new nonpharmacological alternative to reduce cardiovascular risk factors. The impact of probiotics on the reduction of total cholesterol (TC) remains controversial. We conducted a meta-analysis to showcase the most updated and comprehensive evaluation of the studies. METHODS: Randomized controlled trials (RCTs) were searched from electronic databases, including PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang database dating from January 2007 to January 2017. The curative effects of probiotics on the reduction of TC were assessed using mean difference (MD), as well as their 95% confidence interval (CI). RevMan software (version 5.3) was used to carry out this meta-analysis. RESULTS: Thirty-two RCTs including 1971 patients met the inclusion criteria. Results of this analysis showed that compared with the control group serum TC was significantly reduced in probiotics group [MD = -13.27, 95% CI (-16.74 to 9.80), P < .05]. In addition, specific strains also significantly reduced serum TC, L acidophilus and B lactis [MD = -8.30, 95% CI (-10.44, -6.15), P < .05]; VSL#3 [MD = -11.04, 95% CI (-19.61, -2.48), P < .05]; L plantarum t ≤ 6 weeks: [MD = -1.56, 95% CI (-6.97, -3.86), P < .05] or t > 6 weeks: [MD = -22.18, 95% CI (-28.73, -15.63), P < .05]. Subgroup analysis indicated that the difference of baseline TC, probiotics forms and intervention duration might have a significant impact on the results. However, strains and doses of probiotics had no significant influence on curative effects. CONCLUSION: Available evidence indicates that probiotics supplements can significantly reduce serum TC. Furthermore, higher baseline TC, longer intervention time, and probiotics in capsules form might contribute to a better curative effect. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/29384846/The_effects_of_probiotics_on_total_cholesterol:_A_meta_analysis_of_randomized_controlled_trials_ L2 - http://Insights.ovid.com/pubmed?pmid=29384846 DB - PRIME DP - Unbound Medicine ER -