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The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel.
PLoS Pathog. 2018 01; 14(1):e1006878.PP

Abstract

Potassium (K+) is required by plants for growth and development, and also contributes to immunity against pathogens. However, it has not been established whether pathogens modulate host K+ signaling pathways to enhance virulence and subvert host immunity. Here, we show that the effector protein AvrPiz-t from the rice blast pathogen Magnaporthe oryzae targets a K+ channel to subvert plant immunity. AvrPiz-t interacts with the rice plasma-membrane-localized K+ channel protein OsAKT1 and specifically suppresses the OsAKT1-mediated K+ currents. Genetic and phenotypic analyses show that loss of OsAKT1 leads to decreased K+ content and reduced resistance against M. oryzae. Strikingly, AvrPiz-t interferes with the association of OsAKT1 with its upstream regulator, the cytoplasmic kinase OsCIPK23, which also plays a positive role in K+ absorption and resistance to M. oryzae. Furthermore, we show a direct correlation between blast disease resistance and external K+ status in rice plants. Together, our data present a novel mechanism by which a pathogen suppresses plant host immunity by modulating a host K+ channel.

Authors+Show Affiliations

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, China.State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, China.State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, China.State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China. Department of Plant Pathology, Ohio State University, Columbus, Ohio, United States of America.State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29385213

Citation

Shi, Xuetao, et al. "The Fungal Pathogen Magnaporthe Oryzae Suppresses Innate Immunity By Modulating a Host Potassium Channel." PLoS Pathogens, vol. 14, no. 1, 2018, pp. e1006878.
Shi X, Long Y, He F, et al. The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel. PLoS Pathog. 2018;14(1):e1006878.
Shi, X., Long, Y., He, F., Zhang, C., Wang, R., Zhang, T., Wu, W., Hao, Z., Wang, Y., Wang, G. L., & Ning, Y. (2018). The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel. PLoS Pathogens, 14(1), e1006878. https://doi.org/10.1371/journal.ppat.1006878
Shi X, et al. The Fungal Pathogen Magnaporthe Oryzae Suppresses Innate Immunity By Modulating a Host Potassium Channel. PLoS Pathog. 2018;14(1):e1006878. PubMed PMID: 29385213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel. AU - Shi,Xuetao, AU - Long,Yu, AU - He,Feng, AU - Zhang,Chongyang, AU - Wang,Ruyi, AU - Zhang,Ting, AU - Wu,Wei, AU - Hao,Zeyun, AU - Wang,Yi, AU - Wang,Guo-Liang, AU - Ning,Yuese, Y1 - 2018/01/31/ PY - 2017/10/05/received PY - 2018/01/12/accepted PY - 2018/02/12/revised PY - 2018/2/1/pubmed PY - 2018/7/7/medline PY - 2018/2/1/entrez SP - e1006878 EP - e1006878 JF - PLoS pathogens JO - PLoS Pathog VL - 14 IS - 1 N2 - Potassium (K+) is required by plants for growth and development, and also contributes to immunity against pathogens. However, it has not been established whether pathogens modulate host K+ signaling pathways to enhance virulence and subvert host immunity. Here, we show that the effector protein AvrPiz-t from the rice blast pathogen Magnaporthe oryzae targets a K+ channel to subvert plant immunity. AvrPiz-t interacts with the rice plasma-membrane-localized K+ channel protein OsAKT1 and specifically suppresses the OsAKT1-mediated K+ currents. Genetic and phenotypic analyses show that loss of OsAKT1 leads to decreased K+ content and reduced resistance against M. oryzae. Strikingly, AvrPiz-t interferes with the association of OsAKT1 with its upstream regulator, the cytoplasmic kinase OsCIPK23, which also plays a positive role in K+ absorption and resistance to M. oryzae. Furthermore, we show a direct correlation between blast disease resistance and external K+ status in rice plants. Together, our data present a novel mechanism by which a pathogen suppresses plant host immunity by modulating a host K+ channel. SN - 1553-7374 UR - https://www.unboundmedicine.com/medline/citation/29385213/The_fungal_pathogen_Magnaporthe_oryzae_suppresses_innate_immunity_by_modulating_a_host_potassium_channel_ L2 - https://dx.plos.org/10.1371/journal.ppat.1006878 DB - PRIME DP - Unbound Medicine ER -