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Formulation and evaluation of diclofenac controlled release matrix tablets made of HPMC and Poloxamer 188 polymer: An assessment on mechanism of drug release.
Pak J Pharm Sci. 2018 Jan; 31(1(Suppl.)):345-351.PJ

Abstract

In this study, hydrophilic hydroxypropyl methylcellulose matrices with various concentrations of Poloxamer 188 were used in the development of oral controlled release tablets containing diclofenac sodium. Four formulations of hydrophilic matrix tablets containing 16.7% w/w HPMC and 0, 6.7, 16.7 and 25.0% w/w Poloxamer 188, respectively, were developed. Tablets were prepared by direct compression and characterized for diameter, hardness, thickness, weight and uniformity of content. The influence of various blends of hydroxypropyl methylcellulose and Poloxamer 188 on the in vitro dissolution profile and mechanism of drug release of was investigated. In the four formulations, the rate of drug release decreased with increasing the concentration of Poloxamer 188 at the initial dissolution stages due to the increase in the apparent viscosity of the gel diffusion layer. However, in the late dissolution stages, the rate of drug release increased with increasing Poloxamer 188 concentration due to the increase in wettability and dissolution of the matrix. The kinetic of drug release from the tablets followed non-Fickian mechanism, as predicted by Korsmeyer-Peppas model, which involves diffusion through the gel layer and erosion of the matrix system.

Authors+Show Affiliations

Al-Hanbali OA
1Faculty of Pharmacy, The University of Sydney, Sydney NSW, Australia / Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Hamed R
Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Arafat M
College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi, UAE.
Bakkour Y
Faculty of Science, Lebanese University, Tripoli, Lebanon.
Al-Matubsi H
Faculty of Pharmacy, University of Petra, Amman, Jordan.
Mansour R
Faculty of Pharmacy, Philadelphia University, Amman, Jordan.
Al-Bataineh Y
Faculty of Pharmacy, Philadelphia University, Amman, Jordan.
Aldhoun M
Faculty of Pharmacy, Philadelphia University, Amman, Jordan.
Sarfraz M
College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi, UAE.
Dardas AKY
Dana Pharmaceuticals Factory, Nablus-West Bank, Palestinian Authority.

MeSH

Delayed-Action PreparationsDiclofenacDrug CompoundingDrug LiberationHydrophobic and Hydrophilic InteractionsHypromellose DerivativesKineticsModels, ChemicalPoloxamerRheologyTabletsViscosity

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29386164

Citation

Al-Hanbali, Othman A., et al. "Formulation and Evaluation of Diclofenac Controlled Release Matrix Tablets Made of HPMC and Poloxamer 188 Polymer: an Assessment On Mechanism of Drug Release." Pakistan Journal of Pharmaceutical Sciences, vol. 31, no. 1(Suppl.), 2018, pp. 345-351.
Al-Hanbali OA, Hamed R, Arafat M, et al. Formulation and evaluation of diclofenac controlled release matrix tablets made of HPMC and Poloxamer 188 polymer: An assessment on mechanism of drug release. Pak J Pharm Sci. 2018;31(1(Suppl.)):345-351.
Al-Hanbali, O. A., Hamed, R., Arafat, M., Bakkour, Y., Al-Matubsi, H., Mansour, R., Al-Bataineh, Y., Aldhoun, M., Sarfraz, M., & Dardas, A. K. Y. (2018). Formulation and evaluation of diclofenac controlled release matrix tablets made of HPMC and Poloxamer 188 polymer: An assessment on mechanism of drug release. Pakistan Journal of Pharmaceutical Sciences, 31(1(Suppl.)), 345-351.
Al-Hanbali OA, et al. Formulation and Evaluation of Diclofenac Controlled Release Matrix Tablets Made of HPMC and Poloxamer 188 Polymer: an Assessment On Mechanism of Drug Release. Pak J Pharm Sci. 2018;31(1(Suppl.)):345-351. PubMed PMID: 29386164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation and evaluation of diclofenac controlled release matrix tablets made of HPMC and Poloxamer 188 polymer: An assessment on mechanism of drug release. AU - Al-Hanbali,Othman A, AU - Hamed,Rania, AU - Arafat,Mosab, AU - Bakkour,Youssef, AU - Al-Matubsi,Hisham, AU - Mansour,Randa, AU - Al-Bataineh,Yazan, AU - Aldhoun,Mohammad, AU - Sarfraz,Muhammad, AU - Dardas,Abdel Khaleq Yousef, PY - 2018/2/2/entrez PY - 2018/2/2/pubmed PY - 2019/7/28/medline SP - 345 EP - 351 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 31 IS - 1(Suppl.) N2 - In this study, hydrophilic hydroxypropyl methylcellulose matrices with various concentrations of Poloxamer 188 were used in the development of oral controlled release tablets containing diclofenac sodium. Four formulations of hydrophilic matrix tablets containing 16.7% w/w HPMC and 0, 6.7, 16.7 and 25.0% w/w Poloxamer 188, respectively, were developed. Tablets were prepared by direct compression and characterized for diameter, hardness, thickness, weight and uniformity of content. The influence of various blends of hydroxypropyl methylcellulose and Poloxamer 188 on the in vitro dissolution profile and mechanism of drug release of was investigated. In the four formulations, the rate of drug release decreased with increasing the concentration of Poloxamer 188 at the initial dissolution stages due to the increase in the apparent viscosity of the gel diffusion layer. However, in the late dissolution stages, the rate of drug release increased with increasing Poloxamer 188 concentration due to the increase in wettability and dissolution of the matrix. The kinetic of drug release from the tablets followed non-Fickian mechanism, as predicted by Korsmeyer-Peppas model, which involves diffusion through the gel layer and erosion of the matrix system. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/29386164/Formulation_and_evaluation_of_diclofenac_controlled_release_matrix_tablets_made_of_HPMC_and_Poloxamer_188_polymer:_An_assessment_on_mechanism_of_drug_release_ DB - PRIME DP - Unbound Medicine ER -