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Non Uremic Calciphylaxis Post Liver Transplantation: A Case Report and Literature Review of an Unusual Presentation of a Rare Disease.
Am J Case Rep. 2018 Feb 01; 19:118-122.AJ

Abstract

BACKGROUND

Calciphylaxis results from abnormal calcification of small to medium sized vessels, resulting in painful ischemic necrosis of the surrounding tissues. It is most commonly seen in patients with end stage renal disease on dialysis, but has also been reported in patients with preserved renal function. CASE REPORT We report a case of non uremic calciphylaxis in a 65-year-old female who presented with painful skin lesions and ulcerations involving both thighs one month after receiving a liver transplantation. She was treated with sodium thiosulfate along with wound care and hyperbaric oxygen with complete resolution of the lesions, but with residual scarring.

CONCLUSIONS

Non uremic calciphylaxis is a rare phenomenon that is poorly understood. It should be in the differential of unexplained skin lesions even in the absence of renal insufficiency. Sodium thiosulfate plays a role in treatment, but wound care remains the main focus of treatment.

Authors+Show Affiliations

Department of Nephrology and Hypertension, Kansas University Medical Center, Kansas City, KS, USA.Department of Nephrology and Hypertension, Kansas University Medical Center, Kansas City, KS, USA.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

29386500

Citation

Prabhakar, Swati, and Ahmad M. Tuffaha. "Non Uremic Calciphylaxis Post Liver Transplantation: a Case Report and Literature Review of an Unusual Presentation of a Rare Disease." The American Journal of Case Reports, vol. 19, 2018, pp. 118-122.
Prabhakar S, Tuffaha AM. Non Uremic Calciphylaxis Post Liver Transplantation: A Case Report and Literature Review of an Unusual Presentation of a Rare Disease. Am J Case Rep. 2018;19:118-122.
Prabhakar, S., & Tuffaha, A. M. (2018). Non Uremic Calciphylaxis Post Liver Transplantation: A Case Report and Literature Review of an Unusual Presentation of a Rare Disease. The American Journal of Case Reports, 19, 118-122.
Prabhakar S, Tuffaha AM. Non Uremic Calciphylaxis Post Liver Transplantation: a Case Report and Literature Review of an Unusual Presentation of a Rare Disease. Am J Case Rep. 2018 Feb 1;19:118-122. PubMed PMID: 29386500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non Uremic Calciphylaxis Post Liver Transplantation: A Case Report and Literature Review of an Unusual Presentation of a Rare Disease. AU - Prabhakar,Swati, AU - Tuffaha,Ahmad M, Y1 - 2018/02/01/ PY - 2018/2/2/entrez PY - 2018/2/2/pubmed PY - 2018/9/6/medline SP - 118 EP - 122 JF - The American journal of case reports JO - Am J Case Rep VL - 19 N2 - BACKGROUND Calciphylaxis results from abnormal calcification of small to medium sized vessels, resulting in painful ischemic necrosis of the surrounding tissues. It is most commonly seen in patients with end stage renal disease on dialysis, but has also been reported in patients with preserved renal function. CASE REPORT We report a case of non uremic calciphylaxis in a 65-year-old female who presented with painful skin lesions and ulcerations involving both thighs one month after receiving a liver transplantation. She was treated with sodium thiosulfate along with wound care and hyperbaric oxygen with complete resolution of the lesions, but with residual scarring. CONCLUSIONS Non uremic calciphylaxis is a rare phenomenon that is poorly understood. It should be in the differential of unexplained skin lesions even in the absence of renal insufficiency. Sodium thiosulfate plays a role in treatment, but wound care remains the main focus of treatment. SN - 1941-5923 UR - https://www.unboundmedicine.com/medline/citation/29386500/Non_Uremic_Calciphylaxis_Post_Liver_Transplantation:_A_Case_Report_and_Literature_Review_of_an_Unusual_Presentation_of_a_Rare_Disease_ L2 - https://www.amjcaserep.com/download/index/idArt/906981 DB - PRIME DP - Unbound Medicine ER -