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Circulating vitamin D concentration and risk of prostate cancer: a dose-response meta-analysis of prospective studies.
Ther Clin Risk Manag 2018; 14:95-104TC

Abstract

Background

Though many studies have been performed to elucidate the association between circulating vitamin D and prostate cancer, no conclusive result is available. We carried out a dose-response meta-analysis to quantitatively examine the association of circulating 25-hydroxyvitamin D (25[OH]D) concentration with prostate cancer.

Methods

Only prospective studies examining the associations of circulating 25[OH]D concentration with prostate cancer were eligible for the meta-analysis. A random-effect meta-analysis was done first, to calculate the summary relative risk (RR) and 95% confidence intervals (CIs) comparing the higher concentration with the lower concentration of 25[OH]D. A dose-response meta-analysis using random-effects model was then carried out to evaluate the nonlinearity and calculate the summary RR caused per 10 ng/mL increment.

Results

Nineteen prospective cohort or nested case-control studies were included. Higher 25[OH]D concentration was significantly correlated with elevated risk of prostate cancer (RR =1.15, 95% CI 1.06-1.24). No nonlinear relationship was found between 25[OH]D concentration and risk of prostate cancer (P=0.654). Dose-response meta-analysis showed that the summary RR caused per 10 ng/mL increment in circulating 25[OH]D concentration was 1.04 (95% CI 1.02-1.06). Subgroup analysis also found a modest dose-response relationship. Funnel plot and Egger's test did not detect publication bias.

Conclusion

The findings suggest that highest 25[OH]D concentration is correlated with elevated risk of prostate cancer and a modest dose-response effect exists in this association; however, more studies are needed.

Authors+Show Affiliations

Department of Urology, The First Hospital of Jilin University, Changchun, People's Republic of China.Department of Urology, The First Hospital of Jilin University, Changchun, People's Republic of China.Department of Urology, The First Hospital of Jilin University, Changchun, People's Republic of China.Department of Urology, The First Hospital of Jilin University, Changchun, People's Republic of China.Department of Urology, The First Hospital of Jilin University, Changchun, People's Republic of China.Department of Urology, The First Hospital of Jilin University, Changchun, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29386901

Citation

Gao, Jialin, et al. "Circulating Vitamin D Concentration and Risk of Prostate Cancer: a Dose-response Meta-analysis of Prospective Studies." Therapeutics and Clinical Risk Management, vol. 14, 2018, pp. 95-104.
Gao J, Wei W, Wang G, et al. Circulating vitamin D concentration and risk of prostate cancer: a dose-response meta-analysis of prospective studies. Ther Clin Risk Manag. 2018;14:95-104.
Gao, J., Wei, W., Wang, G., Zhou, H., Fu, Y., & Liu, N. (2018). Circulating vitamin D concentration and risk of prostate cancer: a dose-response meta-analysis of prospective studies. Therapeutics and Clinical Risk Management, 14, pp. 95-104. doi:10.2147/TCRM.S149325.
Gao J, et al. Circulating Vitamin D Concentration and Risk of Prostate Cancer: a Dose-response Meta-analysis of Prospective Studies. Ther Clin Risk Manag. 2018;14:95-104. PubMed PMID: 29386901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating vitamin D concentration and risk of prostate cancer: a dose-response meta-analysis of prospective studies. AU - Gao,Jialin, AU - Wei,Wei, AU - Wang,Gang, AU - Zhou,Honglan, AU - Fu,Yaowen, AU - Liu,Nian, Y1 - 2018/01/09/ PY - 2018/2/2/entrez PY - 2018/2/2/pubmed PY - 2018/2/2/medline KW - dose-response meta-analysis KW - prostate cancer KW - vitamin D SP - 95 EP - 104 JF - Therapeutics and clinical risk management JO - Ther Clin Risk Manag VL - 14 N2 - Background: Though many studies have been performed to elucidate the association between circulating vitamin D and prostate cancer, no conclusive result is available. We carried out a dose-response meta-analysis to quantitatively examine the association of circulating 25-hydroxyvitamin D (25[OH]D) concentration with prostate cancer. Methods: Only prospective studies examining the associations of circulating 25[OH]D concentration with prostate cancer were eligible for the meta-analysis. A random-effect meta-analysis was done first, to calculate the summary relative risk (RR) and 95% confidence intervals (CIs) comparing the higher concentration with the lower concentration of 25[OH]D. A dose-response meta-analysis using random-effects model was then carried out to evaluate the nonlinearity and calculate the summary RR caused per 10 ng/mL increment. Results: Nineteen prospective cohort or nested case-control studies were included. Higher 25[OH]D concentration was significantly correlated with elevated risk of prostate cancer (RR =1.15, 95% CI 1.06-1.24). No nonlinear relationship was found between 25[OH]D concentration and risk of prostate cancer (P=0.654). Dose-response meta-analysis showed that the summary RR caused per 10 ng/mL increment in circulating 25[OH]D concentration was 1.04 (95% CI 1.02-1.06). Subgroup analysis also found a modest dose-response relationship. Funnel plot and Egger's test did not detect publication bias. Conclusion: The findings suggest that highest 25[OH]D concentration is correlated with elevated risk of prostate cancer and a modest dose-response effect exists in this association; however, more studies are needed. SN - 1176-6336 UR - https://www.unboundmedicine.com/medline/citation/29386901/Circulating_vitamin_D_concentration_and_risk_of_prostate_cancer:_a_dose_response_meta_analysis_of_prospective_studies_ L2 - https://dx.doi.org/10.2147/TCRM.S149325 DB - PRIME DP - Unbound Medicine ER -