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Luteolin Could Improve Cognitive Dysfunction by Inhibiting Neuroinflammation.
Neurochem Res 2018; 43(4):806-820NR

Abstract

Neuroinflammation and oxidative stress play an important role in cognition deficit following chronic cerebral hypoperfusion (CCH). Luteolin, a natural flavonoid found in many plants, is known for a variety of pharmacological activities, such as its anti-inflammatory, anti-allergy, urate, anti-tumor, antibacterial, and antiviral effects. To assess whether luteolin could prevent CCH-induced cognitive dysfunction, through its anti-inflammatory and anti-oxidative-stress effects, we used enzyme-linked immunosorbent assays, enzyme activity assays, behavioral methods, immunohistochemistry, and electrophysiology to detect neuroinflammation and oxidative stress, cognition alterations, and long-term potential (LTP), in a bilateral common carotid arteries ligation (2VO) rat model. We demonstrated that CCH increased tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), interleukin 6 (IL-6), and malondialdehyde (MDA), and decreased superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels. Further, it caused microglia over-activation and astrogliosis, learning and short-term memory dysfunction, and an LTP deficit. Luteolin treatment reversed CCH-induced changes. Specifically, luteolin prevented the increase of TNF-α and IL-1β, IL-6, and MDA, improved the activity of SOD and GPx, inhibited microglia over-activation and astrogliosis (particularly in the hippocampus and cortex), and ameliorated learning and short-term memory dysfunction, and LTP deficit. Thus, our study suggested that luteolin could be a preferable anti-inflammatory agent to protect cognitive function and synaptic plasticity following CCH. Luteolin could also be putative therapeutic candidate for other inflammation-related brain diseases.

Authors+Show Affiliations

Department of Geriatrics, Renmin Hospital of Wuhan University, #238 Jiefang Road, Wuhan, 430060, China. yaozhaohui2004@126.com.Department of Neurology, Central Hospital of Zhengzhou, #195 Tongbo Road, Zhengzhou, China.Department of Neurology, Renmin Hospital of Wuhan University, #238 Jiefang Road, Wuhan, China.Department of Neurology, Renmin Hospital of Wuhan University, #238 Jiefang Road, Wuhan, China.Department of Pathology, Renmin Hospital of Wuhan University, #238 Jiefang Road, Wuhan, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29392519

Citation

Yao, Zhao-Hui, et al. "Luteolin Could Improve Cognitive Dysfunction By Inhibiting Neuroinflammation." Neurochemical Research, vol. 43, no. 4, 2018, pp. 806-820.
Yao ZH, Yao XL, Zhang Y, et al. Luteolin Could Improve Cognitive Dysfunction by Inhibiting Neuroinflammation. Neurochem Res. 2018;43(4):806-820.
Yao, Z. H., Yao, X. L., Zhang, Y., Zhang, S. F., & Hu, J. C. (2018). Luteolin Could Improve Cognitive Dysfunction by Inhibiting Neuroinflammation. Neurochemical Research, 43(4), pp. 806-820. doi:10.1007/s11064-018-2482-2.
Yao ZH, et al. Luteolin Could Improve Cognitive Dysfunction By Inhibiting Neuroinflammation. Neurochem Res. 2018;43(4):806-820. PubMed PMID: 29392519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Luteolin Could Improve Cognitive Dysfunction by Inhibiting Neuroinflammation. AU - Yao,Zhao-Hui, AU - Yao,Xiao-Li, AU - Zhang,Yong, AU - Zhang,Shao-Feng, AU - Hu,Ji-Chang, Y1 - 2018/02/01/ PY - 2017/10/03/received PY - 2018/01/20/accepted PY - 2018/01/15/revised PY - 2018/2/3/pubmed PY - 2018/9/25/medline PY - 2018/2/3/entrez KW - Chronic cerebral hypoperfusion KW - Cognition dysfunction KW - Luteolin KW - Neuroinflammation SP - 806 EP - 820 JF - Neurochemical research JO - Neurochem. Res. VL - 43 IS - 4 N2 - Neuroinflammation and oxidative stress play an important role in cognition deficit following chronic cerebral hypoperfusion (CCH). Luteolin, a natural flavonoid found in many plants, is known for a variety of pharmacological activities, such as its anti-inflammatory, anti-allergy, urate, anti-tumor, antibacterial, and antiviral effects. To assess whether luteolin could prevent CCH-induced cognitive dysfunction, through its anti-inflammatory and anti-oxidative-stress effects, we used enzyme-linked immunosorbent assays, enzyme activity assays, behavioral methods, immunohistochemistry, and electrophysiology to detect neuroinflammation and oxidative stress, cognition alterations, and long-term potential (LTP), in a bilateral common carotid arteries ligation (2VO) rat model. We demonstrated that CCH increased tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), interleukin 6 (IL-6), and malondialdehyde (MDA), and decreased superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels. Further, it caused microglia over-activation and astrogliosis, learning and short-term memory dysfunction, and an LTP deficit. Luteolin treatment reversed CCH-induced changes. Specifically, luteolin prevented the increase of TNF-α and IL-1β, IL-6, and MDA, improved the activity of SOD and GPx, inhibited microglia over-activation and astrogliosis (particularly in the hippocampus and cortex), and ameliorated learning and short-term memory dysfunction, and LTP deficit. Thus, our study suggested that luteolin could be a preferable anti-inflammatory agent to protect cognitive function and synaptic plasticity following CCH. Luteolin could also be putative therapeutic candidate for other inflammation-related brain diseases. SN - 1573-6903 UR - https://www.unboundmedicine.com/medline/citation/29392519/Luteolin_Could_Improve_Cognitive_Dysfunction_by_Inhibiting_Neuroinflammation_ L2 - https://doi.org/10.1007/s11064-018-2482-2 DB - PRIME DP - Unbound Medicine ER -