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The Impact of Skeletal Muscle Depletion on Head and Neck Squamous Cell Carcinoma.

Abstract

BACKGROUND

Skeletal muscle depletion and sarcopenia have been reported as poor prognostic factors for several types of cancer. The aim of this study was to investigate the prognostic impact of skeletal muscle depletion and sarcopenia on the outcomes in head and neck cancer patients.

METHODS

Patients with head and neck squamous cell carcinoma (HNSCC) treated from January 2013 to June 2014 were included in this study. The pretreatment cross-sectional area of skeletal muscle at the third lumbar vertebra (L3) was measured by computed tomography image analysis using the ImageJ software. L3 skeletal muscle index (SMI) and fat-free mass (FFM) were calculated.

RESULTS

Eighty-five patients with HNSCC were included. The cut-off value of sarcopenia was set at SMI <46.7 cm2/m2 (males) and 30.3 cm2/m2 (females). The cut-off value of FFM was set at 42.3 kg (males) and 30.6 kg (females). Patients with a low SMI (sarcopenia) and low FFM had a significantly poorer prognosis than others, especially those who received definitive radiotherapy. Sarcopenia and low FFM are independent factors for poor prognosis in patients with HNSCC.

CONCLUSION

The skeletal muscle area at L3 should be calculated when considering treatment options for head and neck cancer.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29393251

Citation

Nishikawa, Daisuke, et al. "The Impact of Skeletal Muscle Depletion On Head and Neck Squamous Cell Carcinoma." ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, vol. 80, no. 1, 2018, pp. 1-9.
Nishikawa D, Hanai N, Suzuki H, et al. The Impact of Skeletal Muscle Depletion on Head and Neck Squamous Cell Carcinoma. ORL J Otorhinolaryngol Relat Spec. 2018;80(1):1-9.
Nishikawa, D., Hanai, N., Suzuki, H., Koide, Y., Beppu, S., & Hasegawa, Y. (2018). The Impact of Skeletal Muscle Depletion on Head and Neck Squamous Cell Carcinoma. ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, 80(1), pp. 1-9. doi:10.1159/000485515.
Nishikawa D, et al. The Impact of Skeletal Muscle Depletion On Head and Neck Squamous Cell Carcinoma. ORL J Otorhinolaryngol Relat Spec. 2018;80(1):1-9. PubMed PMID: 29393251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Impact of Skeletal Muscle Depletion on Head and Neck Squamous Cell Carcinoma. AU - Nishikawa,Daisuke, AU - Hanai,Nobuhiro, AU - Suzuki,Hidenori, AU - Koide,Yusuke, AU - Beppu,Shintaro, AU - Hasegawa,Yasuhisa, Y1 - 2018/01/26/ PY - 2017/07/27/received PY - 2017/11/20/accepted PY - 2018/2/3/pubmed PY - 2018/11/21/medline PY - 2018/2/3/entrez KW - Fat-free mass KW - Head and neck cancer KW - ImageJ KW - Sarcopenia KW - Skeletal muscle index SP - 1 EP - 9 JF - ORL; journal for oto-rhino-laryngology and its related specialties JO - ORL J. Otorhinolaryngol. Relat. Spec. VL - 80 IS - 1 N2 - BACKGROUND: Skeletal muscle depletion and sarcopenia have been reported as poor prognostic factors for several types of cancer. The aim of this study was to investigate the prognostic impact of skeletal muscle depletion and sarcopenia on the outcomes in head and neck cancer patients. METHODS: Patients with head and neck squamous cell carcinoma (HNSCC) treated from January 2013 to June 2014 were included in this study. The pretreatment cross-sectional area of skeletal muscle at the third lumbar vertebra (L3) was measured by computed tomography image analysis using the ImageJ software. L3 skeletal muscle index (SMI) and fat-free mass (FFM) were calculated. RESULTS: Eighty-five patients with HNSCC were included. The cut-off value of sarcopenia was set at SMI <46.7 cm2/m2 (males) and 30.3 cm2/m2 (females). The cut-off value of FFM was set at 42.3 kg (males) and 30.6 kg (females). Patients with a low SMI (sarcopenia) and low FFM had a significantly poorer prognosis than others, especially those who received definitive radiotherapy. Sarcopenia and low FFM are independent factors for poor prognosis in patients with HNSCC. CONCLUSION: The skeletal muscle area at L3 should be calculated when considering treatment options for head and neck cancer. SN - 1423-0275 UR - https://www.unboundmedicine.com/medline/citation/29393251/The_Impact_of_Skeletal_Muscle_Depletion_on_Head_and_Neck_Squamous_Cell_Carcinoma_ L2 - https://www.karger.com?DOI=10.1159/000485515 DB - PRIME DP - Unbound Medicine ER -