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The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials.
Crit Rev Food Sci Nutr. 2019; 59(11):1753-1766.CR

Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to summarize the effect of ginger intake on weight loss, glycemic control and lipid profiles among overweight and obese subjects. We searched the following databases through November 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as Standardized Mean Difference (SMD) with 95% Confidence Intervals (95% CI). Heterogeneity between studies was assessed by the Cochran Q statistic and I-squared tests (I2). Overall, 14 studies were included in the meta-analyses. Fourteen RCTs with 473 subjects were included in our meta-analysis. The results indicated that the supplementation with ginger significantly decreased body weight (BW) (SMD -0.66; 95% CI, -1.31, -0.01; P = 0.04), waist-to-hip ratio (WHR) (SMD -0.49; 95% CI, -0.82, -0.17; P = 0.003), hip ratio (HR) (SMD -0.42; 95% CI, -0.77, -0.08; P = 0.01), fasting glucose (SMD -0.68; 95% CI, -1.23, -0.05; P = 0.03) and insulin resistance index (HOMA-IR) (SMD -1.67; 95% CI, -2.86, -0.48; P = 0.006), and significantly increased HDL-cholesterol levels (SMD 0.40; 95% CI, 0.10, 0.70; P = 0.009). We found no detrimental effect of ginger on body mass index (BMI) (SMD -0.65; 95% CI, -1.36, 0.06; P = 0.074), insulin (SMD -0.54; 95% CI, -1.43, 0.35; P = 0.23), triglycerides (SMD -0.27; 95% CI, -0.71, 0.18; P = 0.24), total- (SMD -0.20; 95% CI, -0.58, 0.18; P = 0.30) and LDL-cholesterol (SMD -0.13; 95% CI, -0.51, 0.24; P = 0.48). Overall, the current meta-analysis demonstrated that ginger intake reduced BW, WHR, HR, fasting glucose and HOMA-IR, and increased HDL-cholesterol, but did not affect insulin, BMI, triglycerides, total- and LDL-cholesterol levels.

Authors+Show Affiliations

a Health Policy Research Center, Shiraz University of Medical Sciences , Shiraz , Iran.b Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences , Shiraz , Iran.a Health Policy Research Center, Shiraz University of Medical Sciences , Shiraz , Iran.c Department of Epidemiology , Shiraz University of Medical Sciences, Shiraz University of Medical Sciences , Shiraz , Iran.b Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences , Shiraz , Iran.d Indigenous and Global Health Research, Department of Medicine , University of Alberta , Edmonton , Canada.e Department of Gynecology and Obstetrics , School of Medicine, Iran University of Medical Sciences , Tehran , Iran.f Department of Urology , School of Medicine, Alborz University of Medical Sciences , Karaj , Iran.g Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , Kashan , I.R. Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

29393665

Citation

Maharlouei, Najmeh, et al. "The Effects of Ginger Intake On Weight Loss and Metabolic Profiles Among Overweight and Obese Subjects: a Systematic Review and Meta-analysis of Randomized Controlled Trials." Critical Reviews in Food Science and Nutrition, vol. 59, no. 11, 2019, pp. 1753-1766.
Maharlouei N, Tabrizi R, Lankarani KB, et al. The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2019;59(11):1753-1766.
Maharlouei, N., Tabrizi, R., Lankarani, K. B., Rezaianzadeh, A., Akbari, M., Kolahdooz, F., Rahimi, M., Keneshlou, F., & Asemi, Z. (2019). The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition, 59(11), 1753-1766. https://doi.org/10.1080/10408398.2018.1427044
Maharlouei N, et al. The Effects of Ginger Intake On Weight Loss and Metabolic Profiles Among Overweight and Obese Subjects: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Crit Rev Food Sci Nutr. 2019;59(11):1753-1766. PubMed PMID: 29393665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials. AU - Maharlouei,Najmeh, AU - Tabrizi,Reza, AU - Lankarani,Kamran B, AU - Rezaianzadeh,Abbas, AU - Akbari,Maryam, AU - Kolahdooz,Fariba, AU - Rahimi,Maryam, AU - Keneshlou,Fariba, AU - Asemi,Zatollah, Y1 - 2018/02/02/ PY - 2018/2/3/pubmed PY - 2019/12/18/medline PY - 2018/2/3/entrez KW - Ginger KW - meta-analysis KW - metabolic profiles KW - overweight KW - weight loss SP - 1753 EP - 1766 JF - Critical reviews in food science and nutrition JO - Crit Rev Food Sci Nutr VL - 59 IS - 11 N2 - This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to summarize the effect of ginger intake on weight loss, glycemic control and lipid profiles among overweight and obese subjects. We searched the following databases through November 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as Standardized Mean Difference (SMD) with 95% Confidence Intervals (95% CI). Heterogeneity between studies was assessed by the Cochran Q statistic and I-squared tests (I2). Overall, 14 studies were included in the meta-analyses. Fourteen RCTs with 473 subjects were included in our meta-analysis. The results indicated that the supplementation with ginger significantly decreased body weight (BW) (SMD -0.66; 95% CI, -1.31, -0.01; P = 0.04), waist-to-hip ratio (WHR) (SMD -0.49; 95% CI, -0.82, -0.17; P = 0.003), hip ratio (HR) (SMD -0.42; 95% CI, -0.77, -0.08; P = 0.01), fasting glucose (SMD -0.68; 95% CI, -1.23, -0.05; P = 0.03) and insulin resistance index (HOMA-IR) (SMD -1.67; 95% CI, -2.86, -0.48; P = 0.006), and significantly increased HDL-cholesterol levels (SMD 0.40; 95% CI, 0.10, 0.70; P = 0.009). We found no detrimental effect of ginger on body mass index (BMI) (SMD -0.65; 95% CI, -1.36, 0.06; P = 0.074), insulin (SMD -0.54; 95% CI, -1.43, 0.35; P = 0.23), triglycerides (SMD -0.27; 95% CI, -0.71, 0.18; P = 0.24), total- (SMD -0.20; 95% CI, -0.58, 0.18; P = 0.30) and LDL-cholesterol (SMD -0.13; 95% CI, -0.51, 0.24; P = 0.48). Overall, the current meta-analysis demonstrated that ginger intake reduced BW, WHR, HR, fasting glucose and HOMA-IR, and increased HDL-cholesterol, but did not affect insulin, BMI, triglycerides, total- and LDL-cholesterol levels. SN - 1549-7852 UR - https://www.unboundmedicine.com/medline/citation/29393665/The_effects_of_ginger_intake_on_weight_loss_and_metabolic_profiles_among_overweight_and_obese_subjects:_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - https://www.tandfonline.com/doi/full/10.1080/10408398.2018.1427044 DB - PRIME DP - Unbound Medicine ER -