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Haemophilus influenzae-protein D specific antibody correlate with protection against acute otitis media in young children.
Vaccine. 2018 02 21; 36(9):1133-1135.V

Abstract

BACKGROUND

Haemophilus influenzae (Hi) causes respiratory infections and pathogenesis of this microbe begins in the human nasopharynx (NP). The objective of this study was to assess the correlation of NP colonization-induced serum antibody levels to Hi protein D with risk of acute otitis media (AOM) in children <2 yr.

METHODS

455 sera from 213 children (age 6-24 months old) were collected when they were colonized with Hi and when the children developed AOM. Presence of Hi during AOM was confirmed by culture of middle ear fluid. Quantitative ELISA was used to determine serum IgG against protein D antigen.

RESULTS

Asymptomatic Hi NP colonization reduced the risk of future AOM infections. Higher serum IgG titers against Hi protein D were correlated with reduced future AOM risk.

CONCLUSION

Colonization by Hi reduces future AOM risk. Higher antibody levels against protein D correlates with lower risk of AOM caused by Hi.

Authors+Show Affiliations

Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, USA.Center for Infectious Disease and Immunology, Rochester General Hospital Research Institute, Rochester, NY, USA. Electronic address: michael.pichichero@rochesterregional.org.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29395516

Citation

Almudevar, Anthony, and Michael E. Pichichero. "Haemophilus Influenzae-protein D Specific Antibody Correlate With Protection Against Acute Otitis Media in Young Children." Vaccine, vol. 36, no. 9, 2018, pp. 1133-1135.
Almudevar A, Pichichero ME. Haemophilus influenzae-protein D specific antibody correlate with protection against acute otitis media in young children. Vaccine. 2018;36(9):1133-1135.
Almudevar, A., & Pichichero, M. E. (2018). Haemophilus influenzae-protein D specific antibody correlate with protection against acute otitis media in young children. Vaccine, 36(9), 1133-1135. https://doi.org/10.1016/j.vaccine.2018.01.021
Almudevar A, Pichichero ME. Haemophilus Influenzae-protein D Specific Antibody Correlate With Protection Against Acute Otitis Media in Young Children. Vaccine. 2018 02 21;36(9):1133-1135. PubMed PMID: 29395516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haemophilus influenzae-protein D specific antibody correlate with protection against acute otitis media in young children. AU - Almudevar,Anthony, AU - Pichichero,Michael E, Y1 - 2018/02/01/ PY - 2017/11/08/received PY - 2018/01/09/revised PY - 2018/01/10/accepted PY - 2018/2/6/pubmed PY - 2018/10/13/medline PY - 2018/2/4/entrez KW - Antibody response KW - Correlate of protection KW - Haemophilus influenzae SP - 1133 EP - 1135 JF - Vaccine JO - Vaccine VL - 36 IS - 9 N2 - BACKGROUND: Haemophilus influenzae (Hi) causes respiratory infections and pathogenesis of this microbe begins in the human nasopharynx (NP). The objective of this study was to assess the correlation of NP colonization-induced serum antibody levels to Hi protein D with risk of acute otitis media (AOM) in children <2 yr. METHODS: 455 sera from 213 children (age 6-24 months old) were collected when they were colonized with Hi and when the children developed AOM. Presence of Hi during AOM was confirmed by culture of middle ear fluid. Quantitative ELISA was used to determine serum IgG against protein D antigen. RESULTS: Asymptomatic Hi NP colonization reduced the risk of future AOM infections. Higher serum IgG titers against Hi protein D were correlated with reduced future AOM risk. CONCLUSION: Colonization by Hi reduces future AOM risk. Higher antibody levels against protein D correlates with lower risk of AOM caused by Hi. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/29395516/Haemophilus_influenzae_protein_D_specific_antibody_correlate_with_protection_against_acute_otitis_media_in_young_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(18)30055-0 DB - PRIME DP - Unbound Medicine ER -