Tags

Type your tag names separated by a space and hit enter

Reversible Silencing of the Frontopolar Cortex Selectively Impairs Metacognitive Judgment on Non-experience in Primates.
Neuron. 2018 02 21; 97(4):980-989.e6.N

Abstract

Self-evaluation of one's own ignorance requires us to peer into our own mind retrospectively. Here, we found that only the bilateral frontopolar cortices (area 10) are recruited for metacognitive evaluation of non-experienced events in macaque monkeys performing metacognitive confidence judgment on memory under fMRI scanning and that targeted reversible inactivation of the localized spots in area 10 selectively impaired the confidence judgment of non-experienced events. In contrast, fMRI experiments revealed that area 10 was not recruited for metacognition of experienced events like the way that the dorsal prefrontal cortex (area 9) was and, correspondingly, the inactivation of area 10 did not impair confidence judgment of experienced events. Notably, this inactivation did not impair the ability to identify novel events by distinguishing from repetitive events. Our findings elucidate that the frontopolar cortex plays a causal role to confer not awareness of past experience in general but awareness of one's own ignorance.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Miyamoto K
Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Setsuie R
Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Osada T
Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Miyashita Y
Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address: yasushi.miyashita@m.u-tokyo.ac.jp.

MeSH

AnimalsBrain MappingFemaleJudgmentMacacaMagnetic Resonance ImagingMetacognitionPrefrontal CortexRecognition, Psychology

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29395916

Citation

Miyamoto, Kentaro, et al. "Reversible Silencing of the Frontopolar Cortex Selectively Impairs Metacognitive Judgment On Non-experience in Primates." Neuron, vol. 97, no. 4, 2018, pp. 980-989.e6.
Miyamoto K, Setsuie R, Osada T, et al. Reversible Silencing of the Frontopolar Cortex Selectively Impairs Metacognitive Judgment on Non-experience in Primates. Neuron. 2018;97(4):980-989.e6.
Miyamoto, K., Setsuie, R., Osada, T., & Miyashita, Y. (2018). Reversible Silencing of the Frontopolar Cortex Selectively Impairs Metacognitive Judgment on Non-experience in Primates. Neuron, 97(4), 980-e6. https://doi.org/10.1016/j.neuron.2017.12.040
Miyamoto K, et al. Reversible Silencing of the Frontopolar Cortex Selectively Impairs Metacognitive Judgment On Non-experience in Primates. Neuron. 2018 02 21;97(4):980-989.e6. PubMed PMID: 29395916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reversible Silencing of the Frontopolar Cortex Selectively Impairs Metacognitive Judgment on Non-experience in Primates. AU - Miyamoto,Kentaro, AU - Setsuie,Rieko, AU - Osada,Takahiro, AU - Miyashita,Yasushi, Y1 - 2018/02/03/ PY - 2017/05/30/received PY - 2017/11/04/revised PY - 2017/12/22/accepted PY - 2018/2/6/pubmed PY - 2019/7/16/medline PY - 2018/2/4/entrez KW - GABA-A receptor agonist KW - area 10 KW - confidence judgement KW - frontopolar cortex KW - functional MRI KW - ignorance KW - macaque monkeys KW - metacognition KW - post-decision wagering KW - whole-brain mapping SP - 980 EP - 989.e6 JF - Neuron JO - Neuron VL - 97 IS - 4 N2 - Self-evaluation of one's own ignorance requires us to peer into our own mind retrospectively. Here, we found that only the bilateral frontopolar cortices (area 10) are recruited for metacognitive evaluation of non-experienced events in macaque monkeys performing metacognitive confidence judgment on memory under fMRI scanning and that targeted reversible inactivation of the localized spots in area 10 selectively impaired the confidence judgment of non-experienced events. In contrast, fMRI experiments revealed that area 10 was not recruited for metacognition of experienced events like the way that the dorsal prefrontal cortex (area 9) was and, correspondingly, the inactivation of area 10 did not impair confidence judgment of experienced events. Notably, this inactivation did not impair the ability to identify novel events by distinguishing from repetitive events. Our findings elucidate that the frontopolar cortex plays a causal role to confer not awareness of past experience in general but awareness of one's own ignorance. SN - 1097-4199 UR - https://www.unboundmedicine.com/medline/citation/29395916/Reversible_Silencing_of_the_Frontopolar_Cortex_Selectively_Impairs_Metacognitive_Judgment_on_Non_experience_in_Primates_ DB - PRIME DP - Unbound Medicine ER -