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Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?
Trends Parasitol. 2018 03; 34(3):197-207.TP

Abstract

Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between 1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations at risk, drug donations, and efforts by national and international stakeholders have brought the epidemic under control with <2200 cases in 2016. The World Health Organization (WHO) has set the goals of gambiense-HAT elimination as a public health problem for 2020, and of interruption of transmission to humans for 2030. Latent human infections and possible animal reservoirs may challenge these goals. It remains largely unknown whether, and to what extend, they have an impact on gambiense-HAT transmission. We argue that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies.

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Authors+Show Affiliations

Informal Expert Group on Gambiense HAT Reservoirs
No affiliation info available
Büscher P
Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium. Electronic address: pbuscher@itg.be.
Bart JM
INTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France; Centro Nacional de Medicina Tropical, Instituto de Salud Carlos III, Calle Sinesio Delgado 4, 28029 Madrid, Spain.
Boelaert M
Department of Public Health, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.
Bucheton B
INTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France.
Cecchi G
Sub-regional Office for Eastern Africa, Food and Agriculture Organization of the United Nations, CMC Road, Bole Sub City, Kebele 12/13, P O Box 5536, Addis Ababa, Ethiopia.
Chitnis N
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, Postfach, 4002 Basel, Switzerland; University of Basel, Switzerland.
Courtin D
Université Paris Descartes, Institut de Recherche pour le Développement, Unité MERIT, Mère et enfant face aux infections tropicales, 4 avenue de l'Observatoire, 75006 Paris, France.
Figueiredo LM
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Prof Egas Moniz, 1649-028 Lisboa, Portugal.
Franco JR
Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, World Health Organization, Via Appia 20, 1202 Geneva, Switzerland.
Grébaut P
INTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France.
Hasker E
Department of Public Health, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.
Ilboudo H
Institut de Recherche sur les Bases Biologiques de la Lutte Intégrée, Centre International de Recherche-Développement sur l'Élevage en zone Subhumide, 01 BP 454 Bobo-Dioulasso 01, Burkina Faso.
Jamonneau V
INTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France.
Koffi M
Université Jean Lorougnon Guédé, BP 150 Daloa, Côte d'Ivoire.
Lejon V
INTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France.
MacLeod A
Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Henry Wellcome Building, 464 Bearsden Road, Glasgow, UK.
Masumu J
Département de Parasitologie, Institut National de Recherche Biomédicale, Avenue de la Démocratie, BP 1197 Kinshasa 1, République Démocratique du Congo.
Matovu E
College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, P O Box 7062 Kampala, Uganda.
Mattioli R
Animal Production and Health Division, Food and Agriculture Organization of the United Nations, Viale delle Terme di Caracalla, 00153 Rome, Italy.
Noyes H
Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Picado A
Foundation for Innovative New Diagnostics, 9 Chemin des Mines, 1202 Geneva, Switzerland.
Rock KS
Zeeman Institute for Systems Biology & Infectious Disease Research, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
Rotureau B
Trypanosome Transmission Group, Trypanosome Cell Biology Unit, INSERM U1201 and Department of Parasites and Insect Vectors, Institut Pasteur, 25, rue du Docteur Roux, 75015 Paris, France.
Simo G
Department of Biochemistry, Faculty of Science, University of Dschang, P O Box 67 Dschang, Cameroon.
Thévenon S
INTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France; CIRAD, INTERTRYP, Montpellier, France.
Trindade S
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Prof Egas Moniz, 1649-028 Lisboa, Portugal.
Truc P
INTERTRYP, IRD, CIRAD, Univ Montpellier, Montpellier, France.
Van Reet N
Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.

MeSH

AnimalsDisease EradicationDisease ReservoirsHumansRisk FactorsTrypanosoma brucei gambienseTrypanosomiasis, African

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29396200

Citation

Informal Expert Group on Gambiense HAT Reservoirs, et al. "Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?" Trends in Parasitology, vol. 34, no. 3, 2018, pp. 197-207.
Informal Expert Group on Gambiense HAT Reservoirs, Büscher P, Bart JM, et al. Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination? Trends Parasitol. 2018;34(3):197-207.
Büscher, P., Bart, J. M., Boelaert, M., Bucheton, B., Cecchi, G., Chitnis, N., Courtin, D., Figueiredo, L. M., Franco, J. R., Grébaut, P., Hasker, E., Ilboudo, H., Jamonneau, V., Koffi, M., Lejon, V., MacLeod, A., Masumu, J., Matovu, E., Mattioli, R., ... Van Reet, N. (2018). Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination? Trends in Parasitology, 34(3), 197-207. https://doi.org/10.1016/j.pt.2017.11.008
Informal Expert Group on Gambiense HAT Reservoirs, et al. Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination. Trends Parasitol. 2018;34(3):197-207. PubMed PMID: 29396200.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination? AU - ,, AU - Büscher,Philippe, AU - Bart,Jean-Mathieu, AU - Boelaert,Marleen, AU - Bucheton,Bruno, AU - Cecchi,Giuliano, AU - Chitnis,Nakul, AU - Courtin,David, AU - Figueiredo,Luisa M, AU - Franco,José-Ramon, AU - Grébaut,Pascal, AU - Hasker,Epco, AU - Ilboudo,Hamidou, AU - Jamonneau,Vincent, AU - Koffi,Mathurin, AU - Lejon,Veerle, AU - MacLeod,Annette, AU - Masumu,Justin, AU - Matovu,Enock, AU - Mattioli,Raffaele, AU - Noyes,Harry, AU - Picado,Albert, AU - Rock,Kat S, AU - Rotureau,Brice, AU - Simo,Gustave, AU - Thévenon,Sophie, AU - Trindade,Sandra, AU - Truc,Philippe, AU - Van Reet,Nick, Y1 - 2018/01/23/ PY - 2017/10/06/received PY - 2017/11/18/revised PY - 2017/11/27/accepted PY - 2018/2/6/pubmed PY - 2018/9/22/medline PY - 2018/2/4/entrez KW - Trypanosoma brucei gambiense KW - elimination KW - human African trypanosomiasis KW - reservoir KW - sleeping sickness KW - transmission SP - 197 EP - 207 JF - Trends in parasitology JO - Trends Parasitol VL - 34 IS - 3 N2 - Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between 1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations at risk, drug donations, and efforts by national and international stakeholders have brought the epidemic under control with <2200 cases in 2016. The World Health Organization (WHO) has set the goals of gambiense-HAT elimination as a public health problem for 2020, and of interruption of transmission to humans for 2030. Latent human infections and possible animal reservoirs may challenge these goals. It remains largely unknown whether, and to what extend, they have an impact on gambiense-HAT transmission. We argue that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies. SN - 1471-5007 UR - https://www.unboundmedicine.com/medline/citation/29396200/Do_Cryptic_Reservoirs_Threaten_Gambiense_Sleeping_Sickness_Elimination DB - PRIME DP - Unbound Medicine ER -