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Prospective Cohort Study of Breastfeeding and the Risk of Childhood Asthma.
J Pediatr. 2018 04; 195:182-189.e2.JPed

Abstract

OBJECTIVES

To study whether the duration of breastfeeding and time for introduction of complementary foods was associated with the risk of childhood asthma.

STUDY DESIGN

We used data from the Norwegian Mother and Child Study, a nationwide prospective cohort study that recruited pregnant women from across Norway between 1999 and 2008. Children with complete data of breastfeeding up to 18 months and current age >7 years were eligible (n = 41 020). Asthma as the primary outcome was defined based on ≥2 dispensed asthma medications at age 7 years registered in the Norwegian Prescription Database. We used log-binomial regression models to obtain crude relative risks (RRs) in the main analysis, and adjusted for selected confounders in multivariable analyses.

RESULTS

For duration of any breastfeeding, 5.9% of infants breastfed <6 months (adjusted RR [aRR] 1.05, 0.93-1.19) and 4.6% breastfed 6-11 months (aRR 0.96, 0.87-1.07) had dispensed asthma medications at age 7 years compared with 4.6% of infants breastfed ≥12 months (Ptrend .62). Infants still breastfed at 6 months, but introduced to complementary foods <4 months and 4-6 months, had an aRR of 1.15 (0.98-1.36) and 1.09 (0.94-1.27) respectively, compared with infants fully breastfed for 6 months (Ptrend .09). Ages at introduction of solids or formula separately were not significant predictors (Ptrend .16 and .08, respectively).

CONCLUSIONS

We found no association between duration of breastfeeding or age of introduction to complementary foods and asthma at age 7 years.

Authors+Show Affiliations

Pediatric Department, Ostfold Hospital Trust, Grålum, Norway.The Norwegian Institute of Public Health, Oslo, Norway; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; School of social and community medicine, University of Bristol, Bristol, UK.Pediatric Department, Ostfold Hospital Trust, Grålum, Norway.Pediatric Department, Ostfold Hospital Trust, Grålum, Norway; The Norwegian Institute of Public Health, Oslo, Norway. Electronic address: ketil.stordal@fhi.no.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29397158

Citation

Lossius, Anne Kristine, et al. "Prospective Cohort Study of Breastfeeding and the Risk of Childhood Asthma." The Journal of Pediatrics, vol. 195, 2018, pp. 182-189.e2.
Lossius AK, Magnus MC, Lunde J, et al. Prospective Cohort Study of Breastfeeding and the Risk of Childhood Asthma. J Pediatr. 2018;195:182-189.e2.
Lossius, A. K., Magnus, M. C., Lunde, J., & Størdal, K. (2018). Prospective Cohort Study of Breastfeeding and the Risk of Childhood Asthma. The Journal of Pediatrics, 195, 182-e2. https://doi.org/10.1016/j.jpeds.2017.11.065
Lossius AK, et al. Prospective Cohort Study of Breastfeeding and the Risk of Childhood Asthma. J Pediatr. 2018;195:182-189.e2. PubMed PMID: 29397158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective Cohort Study of Breastfeeding and the Risk of Childhood Asthma. AU - Lossius,Anne Kristine, AU - Magnus,Maria Christine, AU - Lunde,Jon, AU - Størdal,Ketil, Y1 - 2018/02/01/ PY - 2017/05/22/received PY - 2017/11/19/revised PY - 2017/11/29/accepted PY - 2018/2/6/pubmed PY - 2019/3/21/medline PY - 2018/2/5/entrez KW - allergy KW - atopy KW - complementary feeding KW - protection SP - 182 EP - 189.e2 JF - The Journal of pediatrics JO - J. Pediatr. VL - 195 N2 - OBJECTIVES: To study whether the duration of breastfeeding and time for introduction of complementary foods was associated with the risk of childhood asthma. STUDY DESIGN: We used data from the Norwegian Mother and Child Study, a nationwide prospective cohort study that recruited pregnant women from across Norway between 1999 and 2008. Children with complete data of breastfeeding up to 18 months and current age >7 years were eligible (n = 41 020). Asthma as the primary outcome was defined based on ≥2 dispensed asthma medications at age 7 years registered in the Norwegian Prescription Database. We used log-binomial regression models to obtain crude relative risks (RRs) in the main analysis, and adjusted for selected confounders in multivariable analyses. RESULTS: For duration of any breastfeeding, 5.9% of infants breastfed <6 months (adjusted RR [aRR] 1.05, 0.93-1.19) and 4.6% breastfed 6-11 months (aRR 0.96, 0.87-1.07) had dispensed asthma medications at age 7 years compared with 4.6% of infants breastfed ≥12 months (Ptrend .62). Infants still breastfed at 6 months, but introduced to complementary foods <4 months and 4-6 months, had an aRR of 1.15 (0.98-1.36) and 1.09 (0.94-1.27) respectively, compared with infants fully breastfed for 6 months (Ptrend .09). Ages at introduction of solids or formula separately were not significant predictors (Ptrend .16 and .08, respectively). CONCLUSIONS: We found no association between duration of breastfeeding or age of introduction to complementary foods and asthma at age 7 years. SN - 1097-6833 UR - https://www.unboundmedicine.com/medline/citation/29397158/Prospective_Cohort_Study_of_Breastfeeding_and_the_Risk_of_Childhood_Asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(17)31621-9 DB - PRIME DP - Unbound Medicine ER -