Abstract
BACKGROUND
Although a number of studies showed a lower risk of hip fractures with high-quality diets, few of them were conducted in the United States.
OBJECTIVE
This prospective analysis examined the association between several diet quality indexes and risk of hip fractures in US men and women.
DESIGN
This is a prospective cohort study.
PARTICIPANTS/SETTING
The participants were 74,446 postmenopausal women from the Nurses' Health Study and 36,602 men aged 50 years and older from the Health Professionals Follow-Up Study in the United States.
MAIN OUTCOME MEASURE
Hip fractures were self-reported on biennial questionnaires between 1980-2012 in women, and between 1986-2012 in men.
STATISTICAL ANALYSIS
Diet was assessed every 4 years with a validated food frequency questionnaire. Relative risks were computed for hip fracture by quintiles of the Alternate Mediterranean Diet score (aMed), the Alternate Healthy Eating Index-2010 (AHEI-2010), and the Dietary Approaches to Stop Hypertension score using Cox proportional hazards models, adjusting for potential confounders.
RESULTS
Two thousand one hundred forty-three incident hip fractures in women and 603 in men were reported during follow-up. A significant inverse trend was observed with the cumulative AHEI-2010 score in women (relative risk comparing extreme quintiles 0.87, 95% CI 0.75 to 1.00; P for trend=0.02). There was also a suggestion of an inverse association with the Dietary Approaches to Stop Hypertension score (P for trend=0.03). In addition, significant inverse trends were observed between all three diet quality scores and hip fractures in women younger than age 75 years but not older women. There was no clear association between diet quality indexes and hip fracture in men.
CONCLUSIONS
Higher AHEI-2010 scores were associated with a lower risk of hip fractures in US women. The inverse associations with diet quality may be more apparent among those younger than age 75 years.
TY - JOUR
T1 - Association between Diet Quality Scores and Risk of Hip Fracture in Postmenopausal Women and Men Aged 50 Years and Older.
AU - Fung,Teresa T,
AU - Meyer,Haakon E,
AU - Willett,Walter C,
AU - Feskanich,Diane,
Y1 - 2018/02/15/
PY - 2017/03/27/received
PY - 2017/11/29/accepted
PY - 2018/2/6/pubmed
PY - 2019/10/15/medline
PY - 2018/2/6/entrez
KW - Diet
KW - Diet quality
KW - Hip fractures
KW - Nutrition
SP - 2269
EP - 2279.e4
JF - Journal of the Academy of Nutrition and Dietetics
JO - J Acad Nutr Diet
VL - 118
IS - 12
N2 - BACKGROUND: Although a number of studies showed a lower risk of hip fractures with high-quality diets, few of them were conducted in the United States. OBJECTIVE: This prospective analysis examined the association between several diet quality indexes and risk of hip fractures in US men and women. DESIGN: This is a prospective cohort study. PARTICIPANTS/SETTING: The participants were 74,446 postmenopausal women from the Nurses' Health Study and 36,602 men aged 50 years and older from the Health Professionals Follow-Up Study in the United States. MAIN OUTCOME MEASURE: Hip fractures were self-reported on biennial questionnaires between 1980-2012 in women, and between 1986-2012 in men. STATISTICAL ANALYSIS: Diet was assessed every 4 years with a validated food frequency questionnaire. Relative risks were computed for hip fracture by quintiles of the Alternate Mediterranean Diet score (aMed), the Alternate Healthy Eating Index-2010 (AHEI-2010), and the Dietary Approaches to Stop Hypertension score using Cox proportional hazards models, adjusting for potential confounders. RESULTS: Two thousand one hundred forty-three incident hip fractures in women and 603 in men were reported during follow-up. A significant inverse trend was observed with the cumulative AHEI-2010 score in women (relative risk comparing extreme quintiles 0.87, 95% CI 0.75 to 1.00; P for trend=0.02). There was also a suggestion of an inverse association with the Dietary Approaches to Stop Hypertension score (P for trend=0.03). In addition, significant inverse trends were observed between all three diet quality scores and hip fractures in women younger than age 75 years but not older women. There was no clear association between diet quality indexes and hip fracture in men. CONCLUSIONS: Higher AHEI-2010 scores were associated with a lower risk of hip fractures in US women. The inverse associations with diet quality may be more apparent among those younger than age 75 years.
SN - 2212-2672
UR - https://www.unboundmedicine.com/medline/citation/29398568/Association_between_Diet_Quality_Scores_and_Risk_of_Hip_Fracture_in_Postmenopausal_Women_and_Men_Aged_50_Years_and_Older_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-2672(17)31850-6
DB - PRIME
DP - Unbound Medicine
ER -