Tags

Type your tag names separated by a space and hit enter

Effects of strategic early-morning caffeine gum administration on association between salivary alpha-amylase and neurobehavioural performance during 50 h of sleep deprivation.
Accid Anal Prev. 2019 May; 126:160-172.AA

Abstract

Self-assessment is the most common method for monitoring performance and safety in the workplace. However, discrepancies between subjective and objective measures have increased interest in physiological assessment of performance. In a double-blind placebo-controlled study, 23 healthy adults were randomly assigned to either a placebo (n = 11; 5 F, 6 M) or caffeine condition (n = 12; 4 F, 8 M) while undergoing 50 h (i.e. two days) of total sleep deprivation. In previous work, higher salivary alpha-amylase (sAA) levels were associated with improved psychomotor vigilance and simulated driving performance in the placebo condition. In this follow-up article, the effects of strategic caffeine administration on the previously reported diurnal profiles of sAA and performance, and the association between sAA and neurobehavioural performance were investigated. Participants were given a 10 h baseline sleep opportunity (monitored via standard polysomnography techniques) prior to undergoing sleep deprivation (total sleep time: placebo = 8.83 ± 0.48 h; caffeine = 9.01 ± 0.48 h). During sleep deprivation, caffeine gum (200 mg) was administered at 01:00 h, 03:00 h, 05:00 h, and 07:00 h to participants in the caffeine condition (n = 12). This strategic administration of caffeine gum (200 mg) has been shown to be effective at maintaining cognitive performance during extended wakefulness. Saliva samples were collected, and psychomotor vigilance and simulated driving performance assessed at three-hour intervals throughout wakefulness. Caffeine effects on diurnal variability were compared with previously reported findings in the placebo condition (n = 11). The impact of caffeine on the circadian profile of sAA coincided with changes in neurobehavioural performance. Higher sAA levels were associated with improved performance on the psychomotor vigilance test during the first 24 h of wakefulness in the caffeine condition. However, only the association between sAA and response speed (i.e. reciprocal-transform of mean reaction time) was consistent across both days of sleep deprivation. The association between sAA and driving performance was not consistent across both days of sleep deprivation. Results show that the relationship between sAA and reciprocal-transform of mean reaction time on the psychomotor vigilance test persisted in the presence of caffeine, however the association was relatively weaker as compared with the placebo condition.

Authors+Show Affiliations

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, AUS. Electronic address: maja.pajcin@mymail.unisa.edu.au.School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, AUS.Centre for Sleep Research, University of South Australia, Magill, SA, AUS.Centre for Sleep Research, University of South Australia, Magill, SA, AUS.Centre for Sleep Research, University of South Australia, Magill, SA, AUS.Centre for Sleep Research, University of South Australia, Magill, SA, AUS.Land Division, Defence Science and Technology Group, Department of Defence, Edinburgh, SA, AUS.Land Division, Defence Science and Technology Group, Department of Defence, Edinburgh, SA, AUS.Land Division, Defence Science and Technology Group, Department of Defence, Edinburgh, SA, AUS.Land Division, Defence Science and Technology Group, Department of Defence, Edinburgh, SA, AUS.Behavioral Biology Branch, Walter Reed Army Institute for Research, Silver Springs, MD, USA.School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, AUS.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29402402

Citation

Pajcin, Maja, et al. "Effects of Strategic Early-morning Caffeine Gum Administration On Association Between Salivary Alpha-amylase and Neurobehavioural Performance During 50 H of Sleep Deprivation." Accident; Analysis and Prevention, vol. 126, 2019, pp. 160-172.
Pajcin M, White JM, Banks S, et al. Effects of strategic early-morning caffeine gum administration on association between salivary alpha-amylase and neurobehavioural performance during 50 h of sleep deprivation. Accid Anal Prev. 2019;126:160-172.
Pajcin, M., White, J. M., Banks, S., Dorrian, J., Paech, G. M., Grant, C. L., Johnson, K., Tooley, K., Aidman, E., Fidock, J., Kamimori, G. H., & Della Vedova, C. B. (2019). Effects of strategic early-morning caffeine gum administration on association between salivary alpha-amylase and neurobehavioural performance during 50 h of sleep deprivation. Accident; Analysis and Prevention, 126, 160-172. https://doi.org/10.1016/j.aap.2018.01.026
Pajcin M, et al. Effects of Strategic Early-morning Caffeine Gum Administration On Association Between Salivary Alpha-amylase and Neurobehavioural Performance During 50 H of Sleep Deprivation. Accid Anal Prev. 2019;126:160-172. PubMed PMID: 29402402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of strategic early-morning caffeine gum administration on association between salivary alpha-amylase and neurobehavioural performance during 50 h of sleep deprivation. AU - Pajcin,Maja, AU - White,Jason M, AU - Banks,Siobhan, AU - Dorrian,Jill, AU - Paech,Gemma M, AU - Grant,Crystal L, AU - Johnson,Kayla, AU - Tooley,Katie, AU - Aidman,Eugene, AU - Fidock,Justin, AU - Kamimori,Gary H, AU - Della Vedova,Chris B, Y1 - 2018/05/07/ PY - 2017/07/12/received PY - 2018/01/18/revised PY - 2018/01/18/accepted PY - 2018/2/7/pubmed PY - 2019/5/31/medline PY - 2018/2/7/entrez KW - Alpha-amylase KW - Biomarker KW - Caffeine KW - Performance KW - Saliva KW - Sleep deprivation SP - 160 EP - 172 JF - Accident; analysis and prevention JO - Accid Anal Prev VL - 126 N2 - Self-assessment is the most common method for monitoring performance and safety in the workplace. However, discrepancies between subjective and objective measures have increased interest in physiological assessment of performance. In a double-blind placebo-controlled study, 23 healthy adults were randomly assigned to either a placebo (n = 11; 5 F, 6 M) or caffeine condition (n = 12; 4 F, 8 M) while undergoing 50 h (i.e. two days) of total sleep deprivation. In previous work, higher salivary alpha-amylase (sAA) levels were associated with improved psychomotor vigilance and simulated driving performance in the placebo condition. In this follow-up article, the effects of strategic caffeine administration on the previously reported diurnal profiles of sAA and performance, and the association between sAA and neurobehavioural performance were investigated. Participants were given a 10 h baseline sleep opportunity (monitored via standard polysomnography techniques) prior to undergoing sleep deprivation (total sleep time: placebo = 8.83 ± 0.48 h; caffeine = 9.01 ± 0.48 h). During sleep deprivation, caffeine gum (200 mg) was administered at 01:00 h, 03:00 h, 05:00 h, and 07:00 h to participants in the caffeine condition (n = 12). This strategic administration of caffeine gum (200 mg) has been shown to be effective at maintaining cognitive performance during extended wakefulness. Saliva samples were collected, and psychomotor vigilance and simulated driving performance assessed at three-hour intervals throughout wakefulness. Caffeine effects on diurnal variability were compared with previously reported findings in the placebo condition (n = 11). The impact of caffeine on the circadian profile of sAA coincided with changes in neurobehavioural performance. Higher sAA levels were associated with improved performance on the psychomotor vigilance test during the first 24 h of wakefulness in the caffeine condition. However, only the association between sAA and response speed (i.e. reciprocal-transform of mean reaction time) was consistent across both days of sleep deprivation. The association between sAA and driving performance was not consistent across both days of sleep deprivation. Results show that the relationship between sAA and reciprocal-transform of mean reaction time on the psychomotor vigilance test persisted in the presence of caffeine, however the association was relatively weaker as compared with the placebo condition. SN - 1879-2057 UR - https://www.unboundmedicine.com/medline/citation/29402402/Effects_of_strategic_early_morning_caffeine_gum_administration_on_association_between_salivary_alpha_amylase_and_neurobehavioural_performance_during_50_h_of_sleep_deprivation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-4575(18)30032-0 DB - PRIME DP - Unbound Medicine ER -