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A Retrospective 2D Morphometric Analysis of Adult Female Chiari Type I Patients with Commonly Reported and Related Conditions.
Front Neuroanat. 2018; 12:2.FN

Abstract

Purpose:

Researchers have sought to better understand Chiari type I malformation (CMI) through morphometric measurements beyond tonsillar position (TP). Soft tissue and bone structures within the brain and craniocervical junction have been shown to be different for CMI patients compared to healthy controls. Yet, several morphological characteristics have not been consistently associated with CMI. CMI is also associated with different prevalent conditions (PCs) such as syringomyelia, pseudotumor, Ehlers-Danlos syndrome (EDS), scoliosis, and craniocervical instability. The goal of this study was two-fold: (1) to identify unique morphological characteristics of PCs, and (2) to better explain inconsistent results from case-control comparisons of CMI.

Methods:

Image, demographic, and PC information was obtained through the Chiari1000, a self-report web-accessed database. Twenty-eight morphometric measurements (MMs) were performed on the cranial MR images of 236 pre-surgery adult female CMI participants and 140 female healthy control participants. Custom software was used to measure 28 structures within the posterior cranial fossa (PCF) compartment, craniocervical junction, oral cavity, and intracranial area on midsagittal MR images for each participant.

Results:

Morphometric analysis of adult females indicated a smaller McRae line length in CMI participants with syringomyelia compared to those without syringomyelia. TP was reduced in CMI participants with EDS than those without EDS. Basion to posterior axial line was significantly longer in CMI participants with scoliosis compared to those without scoliosis. No additional MMs were found to differ between CMI participants with and without a specific PC. Four morphometric differences were found to be consistently different between CMI participants and healthy controls regardless of PC: larger TP and a smaller clivus length, fastigium, and corpus callosum height in CMI participants.

Conclusion:

Syringomyelia, EDS, and scoliosis were the only PCs that showed significant morphometric differences between CMI participants. Additionally, four midsagittal MR-based MMs were found to be significantly different between healthy controls and CMI participants regardless of the presence of one or more PCs. This study suggests that the prevalence of comorbid conditions are not strongly related to CMI morphology, and that inconsistent findings in the radiographic literature cannot be explained by varying prevalence of comorbid conditions in CMI study samples.

Authors+Show Affiliations

Department of Biomedical Engineering, Conquer Chiari Research Center, University of Akron, Akron, OH, United States.Department of Psychology, Conquer Chiari Research Center, University of Akron, Akron, OH, United States.Department of Radiology, University of Michigan Health System, Ann Arbor, MI, United States.Conquer Chiari, Wexford, PA, United States.Department of Psychology, Conquer Chiari Research Center, University of Akron, Akron, OH, United States.Department of Mechanical Engineering, Conquer Chiari Research Center, University of Akron, Akron, OH, United States.Department of Mechanical Engineering, Conquer Chiari Research Center, University of Akron, Akron, OH, United States.Department of Mechanical Engineering, Conquer Chiari Research Center, University of Akron, Akron, OH, United States.Department of Mechanical Engineering, Conquer Chiari Research Center, University of Akron, Akron, OH, United States.Department of Mechanical Engineering, Conquer Chiari Research Center, University of Akron, Akron, OH, United States. Duke University Medical Center, Duke Molecular Physiology Institute, Durham, NC, United States.Department of Biological Engineering, University of Idaho, Moscow, ID, United States.Department of Neurosurgery, University of Michigan Health System, Ann Arbor, MI, United States.Department of Psychology, Conquer Chiari Research Center, University of Akron, Akron, OH, United States.Department of Biomedical Engineering, Conquer Chiari Research Center, University of Akron, Akron, OH, United States. Department of Mechanical Engineering, Conquer Chiari Research Center, University of Akron, Akron, OH, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29403363

Citation

Eppelheimer, Maggie S., et al. "A Retrospective 2D Morphometric Analysis of Adult Female Chiari Type I Patients With Commonly Reported and Related Conditions." Frontiers in Neuroanatomy, vol. 12, 2018, p. 2.
Eppelheimer MS, Houston JR, Bapuraj JR, et al. A Retrospective 2D Morphometric Analysis of Adult Female Chiari Type I Patients with Commonly Reported and Related Conditions. Front Neuroanat. 2018;12:2.
Eppelheimer, M. S., Houston, J. R., Bapuraj, J. R., Labuda, R., Loth, D. M., Braun, A. M., Allen, N. J., Heidari Pahlavian, S., Biswas, D., Urbizu, A., Martin, B. A., Maher, C. O., Allen, P. A., & Loth, F. (2018). A Retrospective 2D Morphometric Analysis of Adult Female Chiari Type I Patients with Commonly Reported and Related Conditions. Frontiers in Neuroanatomy, 12, 2. https://doi.org/10.3389/fnana.2018.00002
Eppelheimer MS, et al. A Retrospective 2D Morphometric Analysis of Adult Female Chiari Type I Patients With Commonly Reported and Related Conditions. Front Neuroanat. 2018;12:2. PubMed PMID: 29403363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Retrospective 2D Morphometric Analysis of Adult Female Chiari Type I Patients with Commonly Reported and Related Conditions. AU - Eppelheimer,Maggie S, AU - Houston,James R, AU - Bapuraj,Jayapalli R, AU - Labuda,Richard, AU - Loth,Dorothy M, AU - Braun,Audrey M, AU - Allen,Natalie J, AU - Heidari Pahlavian,Soroush, AU - Biswas,Dipankar, AU - Urbizu,Aintzane, AU - Martin,Bryn A, AU - Maher,Cormac O, AU - Allen,Philip A, AU - Loth,Francis, Y1 - 2018/01/19/ PY - 2017/09/12/received PY - 2018/01/05/accepted PY - 2018/2/7/entrez PY - 2018/2/7/pubmed PY - 2018/2/7/medline KW - Chiari I malformation KW - MRI KW - comorbidity KW - cranio-vertebral junction KW - morphometry KW - posterior cranial fossa KW - prevalent conditions KW - related conditions SP - 2 EP - 2 JF - Frontiers in neuroanatomy JO - Front Neuroanat VL - 12 N2 - Purpose: Researchers have sought to better understand Chiari type I malformation (CMI) through morphometric measurements beyond tonsillar position (TP). Soft tissue and bone structures within the brain and craniocervical junction have been shown to be different for CMI patients compared to healthy controls. Yet, several morphological characteristics have not been consistently associated with CMI. CMI is also associated with different prevalent conditions (PCs) such as syringomyelia, pseudotumor, Ehlers-Danlos syndrome (EDS), scoliosis, and craniocervical instability. The goal of this study was two-fold: (1) to identify unique morphological characteristics of PCs, and (2) to better explain inconsistent results from case-control comparisons of CMI. Methods: Image, demographic, and PC information was obtained through the Chiari1000, a self-report web-accessed database. Twenty-eight morphometric measurements (MMs) were performed on the cranial MR images of 236 pre-surgery adult female CMI participants and 140 female healthy control participants. Custom software was used to measure 28 structures within the posterior cranial fossa (PCF) compartment, craniocervical junction, oral cavity, and intracranial area on midsagittal MR images for each participant. Results: Morphometric analysis of adult females indicated a smaller McRae line length in CMI participants with syringomyelia compared to those without syringomyelia. TP was reduced in CMI participants with EDS than those without EDS. Basion to posterior axial line was significantly longer in CMI participants with scoliosis compared to those without scoliosis. No additional MMs were found to differ between CMI participants with and without a specific PC. Four morphometric differences were found to be consistently different between CMI participants and healthy controls regardless of PC: larger TP and a smaller clivus length, fastigium, and corpus callosum height in CMI participants. Conclusion: Syringomyelia, EDS, and scoliosis were the only PCs that showed significant morphometric differences between CMI participants. Additionally, four midsagittal MR-based MMs were found to be significantly different between healthy controls and CMI participants regardless of the presence of one or more PCs. This study suggests that the prevalence of comorbid conditions are not strongly related to CMI morphology, and that inconsistent findings in the radiographic literature cannot be explained by varying prevalence of comorbid conditions in CMI study samples. SN - 1662-5129 UR - https://www.unboundmedicine.com/medline/citation/29403363/A_Retrospective_2D_Morphometric_Analysis_of_Adult_Female_Chiari_Type_I_Patients_with_Commonly_Reported_and_Related_Conditions_ L2 - https://doi.org/10.3389/fnana.2018.00002 DB - PRIME DP - Unbound Medicine ER -
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