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Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping.
J Neurol Sci. 2018 03 15; 386:46-52.JN

Abstract

BACKGROUND

Iron deposition within the substantia nigra (SN) has been postulated to play a vital role in Parkinson's disease (PD). The aim of this study was to explore the inherent link of PD patients between their substantia nigra iron accumulation and clinical status using quantitative susceptibility mapping (QSM) which is now considered to be the only quantitative imaging technique of brain iron deposition.

METHODS

44 PD patients and 31 age- and gender-matched healthy controls underwent quantitative susceptibility mapping (QSM) were recruited in this study. We firstly divided the patients into mild symptom severity (MSP) and advanced symptom severity (ASP) groups concerning their disease stage, aiming to illuminate the relationship between iron deposition in SN of PD and disease progression. Then, we classified the patients with Parkinson's disease into three subgroups: tremor-dominant PD (TD), akinetic/rigidity-dominant PD (AR), mixed-PD (M) according to their dominant motor symptoms in order to investigate whether there are any effects of SN iron accumulation to different subtypes of PD patients.

RESULTS

Compared to healthy controls, patients with PD have increased QSM magnetic values in the substantia nigra (138.039±37.320 vs 179.553±65.715; P=0.001). More prominent statistically significance of the difference of SN iron deposition between healthy controls (HC) and advanced symptom severity (ASP) subgroup was displayed (138.039±37.320 vs 232.827±92.040; P<0.001). Besides, among the three clinical phenotypes both TD and AR subgroup showed significant difference compared with healthy controls concerning the QSM values (138.039±37.320 vs 185.864±99.851; P=0.013; 188.148±52.958 vs 138.039±37.320; P=0.001). Furthermore, the iron content in the SN of PD patients was significantly correlated with the Hoehn-Yahr stage, the Unified Parkinson's Disease Rating Scale (UPDRS), Montgomery Asberg Depression Rating Scale (MADRS) and Hamilton Anxiety Scale (HAMA) scores (r=0.417, P=0.005; r=0.300, P=0.048; r=0.540, P<0.001; r=0.553, P<0.001). In MSP the significantly correlation was displayed only in MADRS, HAMA scores (r=0.429, P=0.013; r=0.492, P=0.004), when disease progressed into advanced severity stage all these clinical measures (Hoehn-Yahr stage, UPDRS-3, UPDRS, HAMA, and MADRS scores) we had recruited into this study shown prominent correlation to SN iron content (r=0.650, P=0.030; r=0.709, P=0.015; r=0.708, P=0.015; r=0.758, P=0.007; r=0.683, P=0.020). In the three phenotypes the correlation between iron content and MADRS, HAMA scores (r=0.686, P=0.002; r=0.633, P=0.006) was found in AR subgroups exclusively.

CONCLUSIONS

Patients with PD exhibited significantly higher magnetic susceptibility values, especially in those who are in advanced disease severity stage, which confirmed that iron accumulation in the SN is in line with Parkinson's disease progression. Furthermore, we testified that there are actually some inherent effects of substantia nigra iron deposition to the clinical symptoms of Parkinson's disease. Moreover, it seems that akinetic/rigidity-dominant PD subgroup was affected most by SN iron accumulation.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

An H
Department of Neurology, East Hospital, Tongji University School of Medicine, China.
Zeng X
Department of Neurology, East Hospital, Tongji University School of Medicine, China. Electronic address: 15170813649@163.com.
Niu T
Department of Neurology, East Hospital, Tongji University School of Medicine, China.
Li G
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University Shanghai, China.
Yang J
Department of Neurology, East Hospital, Tongji University School of Medicine, China.
Zheng L
Department of Neurology, East Hospital, Tongji University School of Medicine, China.
Zhou W
Department of Neurology, East Hospital, Tongji University School of Medicine, China.
Liu H
Department of Neurology, East Hospital, Tongji University School of Medicine, China.
Zhang M
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University Shanghai, China.
Huang D
Department of Neurology, East Hospital, Tongji University School of Medicine, China. Electronic address: dongyahuang77@tongji.edu.cn.
Li J
Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University Shanghai, China. Electronic address: jqli@phy.ecnu.edu.cn.

MeSH

AgedBrain MappingCase-Control StudiesFemaleHumansImage Processing, Computer-AssistedIronMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseaseSeverity of Illness IndexStatistics, NonparametricSubstantia Nigra

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29406966

Citation

An, Hedi, et al. "Quantifying Iron Deposition Within the Substantia Nigra of Parkinson's Disease By Quantitative Susceptibility Mapping." Journal of the Neurological Sciences, vol. 386, 2018, pp. 46-52.
An H, Zeng X, Niu T, et al. Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping. J Neurol Sci. 2018;386:46-52.
An, H., Zeng, X., Niu, T., Li, G., Yang, J., Zheng, L., Zhou, W., Liu, H., Zhang, M., Huang, D., & Li, J. (2018). Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping. Journal of the Neurological Sciences, 386, 46-52. https://doi.org/10.1016/j.jns.2018.01.008
An H, et al. Quantifying Iron Deposition Within the Substantia Nigra of Parkinson's Disease By Quantitative Susceptibility Mapping. J Neurol Sci. 2018 03 15;386:46-52. PubMed PMID: 29406966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping. AU - An,Hedi, AU - Zeng,Xiaoyan, AU - Niu,Tengfei, AU - Li,Gaiying, AU - Yang,Jie, AU - Zheng,Lanlan, AU - Zhou,Wei, AU - Liu,Hong, AU - Zhang,Miaomiao, AU - Huang,Dongya, AU - Li,Jianqi, Y1 - 2018/01/12/ PY - 2017/09/14/received PY - 2017/12/08/revised PY - 2018/01/08/accepted PY - 2018/2/7/entrez PY - 2018/2/7/pubmed PY - 2019/5/29/medline KW - Iron deposition KW - Parkinson's disease KW - Quantitative susceptibility mapping KW - Substantia nigra SP - 46 EP - 52 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 386 N2 - BACKGROUND: Iron deposition within the substantia nigra (SN) has been postulated to play a vital role in Parkinson's disease (PD). The aim of this study was to explore the inherent link of PD patients between their substantia nigra iron accumulation and clinical status using quantitative susceptibility mapping (QSM) which is now considered to be the only quantitative imaging technique of brain iron deposition. METHODS: 44 PD patients and 31 age- and gender-matched healthy controls underwent quantitative susceptibility mapping (QSM) were recruited in this study. We firstly divided the patients into mild symptom severity (MSP) and advanced symptom severity (ASP) groups concerning their disease stage, aiming to illuminate the relationship between iron deposition in SN of PD and disease progression. Then, we classified the patients with Parkinson's disease into three subgroups: tremor-dominant PD (TD), akinetic/rigidity-dominant PD (AR), mixed-PD (M) according to their dominant motor symptoms in order to investigate whether there are any effects of SN iron accumulation to different subtypes of PD patients. RESULTS: Compared to healthy controls, patients with PD have increased QSM magnetic values in the substantia nigra (138.039±37.320 vs 179.553±65.715; P=0.001). More prominent statistically significance of the difference of SN iron deposition between healthy controls (HC) and advanced symptom severity (ASP) subgroup was displayed (138.039±37.320 vs 232.827±92.040; P<0.001). Besides, among the three clinical phenotypes both TD and AR subgroup showed significant difference compared with healthy controls concerning the QSM values (138.039±37.320 vs 185.864±99.851; P=0.013; 188.148±52.958 vs 138.039±37.320; P=0.001). Furthermore, the iron content in the SN of PD patients was significantly correlated with the Hoehn-Yahr stage, the Unified Parkinson's Disease Rating Scale (UPDRS), Montgomery Asberg Depression Rating Scale (MADRS) and Hamilton Anxiety Scale (HAMA) scores (r=0.417, P=0.005; r=0.300, P=0.048; r=0.540, P<0.001; r=0.553, P<0.001). In MSP the significantly correlation was displayed only in MADRS, HAMA scores (r=0.429, P=0.013; r=0.492, P=0.004), when disease progressed into advanced severity stage all these clinical measures (Hoehn-Yahr stage, UPDRS-3, UPDRS, HAMA, and MADRS scores) we had recruited into this study shown prominent correlation to SN iron content (r=0.650, P=0.030; r=0.709, P=0.015; r=0.708, P=0.015; r=0.758, P=0.007; r=0.683, P=0.020). In the three phenotypes the correlation between iron content and MADRS, HAMA scores (r=0.686, P=0.002; r=0.633, P=0.006) was found in AR subgroups exclusively. CONCLUSIONS: Patients with PD exhibited significantly higher magnetic susceptibility values, especially in those who are in advanced disease severity stage, which confirmed that iron accumulation in the SN is in line with Parkinson's disease progression. Furthermore, we testified that there are actually some inherent effects of substantia nigra iron deposition to the clinical symptoms of Parkinson's disease. Moreover, it seems that akinetic/rigidity-dominant PD subgroup was affected most by SN iron accumulation. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/29406966/Quantifying_iron_deposition_within_the_substantia_nigra_of_Parkinson's_disease_by_quantitative_susceptibility_mapping_ DB - PRIME DP - Unbound Medicine ER -