Tags

Type your tag names separated by a space and hit enter

Photodegradation of sulfasalazine and its human metabolites in water by UV and UV/peroxydisulfate processes.
Water Res. 2018 04 15; 133:299-309.WR

Abstract

The widespread occurrence of pharmaceuticals and their metabolites in natural waters has raised great concerns about their potential risks on human health and ecological systems. This study systematically investigates the degradation of sulfasalazine (SSZ) and its two human metabolites, sulfapyridine (SPD) and 5-aminosalicylic acid (5-ASA), by UV and UV/peroxydisulfate (UV/PDS) processes. Experimental results show that SPD and 5-ASA were readily degraded upon UV 254 nm direct photolysis, with quantum yields measured to be (8.6 ± 0.8) × 10-3 and (2.4 ± 0.1) × 10-2 mol Einstein-1, respectively. Although SSZ was resistant to direct UV photolysis, it could be effectively removed by both UV/H2O2 and UV/PDS processes, with fluence-based pseudo-first-order rate constants determined to be 0.0030 and 0.0038 cm2 mJ-1, respectively. Second-order rate constant between SO4•- and SSZ was measured as (1.33 ± 0.01) × 109 M-1s-1 by competition kinetic method. A kinetic model was established for predicting the degradation rate of SSZ in the UV/PDS process. Increasing the dosage of PDS significantly enhanced the degradation of SSZ in the UV/PDS process, which can be well predicted by the developed kinetic model. Natural water constituents, such as natural organic matter (NOM) and bicarbonate (HCO3-), influenced the degradation of SSZ differently. The azo functional group of SSZ molecule was predicted as the reactive site susceptible to electrophilic attack by SO4•- by frontier electron densities (FEDs) calculations. Four intermediate products arising from azo bond cleavage and SO2 extrusion were identified by solid phase extraction-liquid chromatography-triple quadrupole mass spectrometry (SPE-LC-MS/MS). Based on the products identified, detailed transformation pathways for SSZ degradation in the UV/PDS system were proposed. Results reveal that UV/PDS could be an efficient approach for remediation of water contaminated by SSZ and its metabolites.

Authors+Show Affiliations

College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: yuefeiji@njau.edu.cn.College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China.Univ Lyon, Université Claude Bernard Lyon 1, CNRS, IRCELYON, F-69626, Villeurbanne, France.College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China.College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: jhlu@njau.edu.cn.Univ Lyon, Université Claude Bernard Lyon 1, CNRS, IRCELYON, F-69626, Villeurbanne, France.Univ Lyon, Université Claude Bernard Lyon 1, CNRS, IRCELYON, F-69626, Villeurbanne, France.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29407711

Citation

Ji, Yuefei, et al. "Photodegradation of Sulfasalazine and Its Human Metabolites in Water By UV and UV/peroxydisulfate Processes." Water Research, vol. 133, 2018, pp. 299-309.
Ji Y, Yang Y, Zhou L, et al. Photodegradation of sulfasalazine and its human metabolites in water by UV and UV/peroxydisulfate processes. Water Res. 2018;133:299-309.
Ji, Y., Yang, Y., Zhou, L., Wang, L., Lu, J., Ferronato, C., & Chovelon, J. M. (2018). Photodegradation of sulfasalazine and its human metabolites in water by UV and UV/peroxydisulfate processes. Water Research, 133, 299-309. https://doi.org/10.1016/j.watres.2018.01.047
Ji Y, et al. Photodegradation of Sulfasalazine and Its Human Metabolites in Water By UV and UV/peroxydisulfate Processes. Water Res. 2018 04 15;133:299-309. PubMed PMID: 29407711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photodegradation of sulfasalazine and its human metabolites in water by UV and UV/peroxydisulfate processes. AU - Ji,Yuefei, AU - Yang,Yan, AU - Zhou,Lei, AU - Wang,Lu, AU - Lu,Junhe, AU - Ferronato,Corinne, AU - Chovelon,Jean-Marc, Y1 - 2018/02/03/ PY - 2017/10/23/received PY - 2017/12/28/revised PY - 2018/01/20/accepted PY - 2018/2/7/pubmed PY - 2018/9/4/medline PY - 2018/2/7/entrez KW - Peroxydisulfate KW - Photolysis KW - Sulfasalazine KW - Sulfate radical KW - UV 254 nm SP - 299 EP - 309 JF - Water research JO - Water Res. VL - 133 N2 - The widespread occurrence of pharmaceuticals and their metabolites in natural waters has raised great concerns about their potential risks on human health and ecological systems. This study systematically investigates the degradation of sulfasalazine (SSZ) and its two human metabolites, sulfapyridine (SPD) and 5-aminosalicylic acid (5-ASA), by UV and UV/peroxydisulfate (UV/PDS) processes. Experimental results show that SPD and 5-ASA were readily degraded upon UV 254 nm direct photolysis, with quantum yields measured to be (8.6 ± 0.8) × 10-3 and (2.4 ± 0.1) × 10-2 mol Einstein-1, respectively. Although SSZ was resistant to direct UV photolysis, it could be effectively removed by both UV/H2O2 and UV/PDS processes, with fluence-based pseudo-first-order rate constants determined to be 0.0030 and 0.0038 cm2 mJ-1, respectively. Second-order rate constant between SO4•- and SSZ was measured as (1.33 ± 0.01) × 109 M-1s-1 by competition kinetic method. A kinetic model was established for predicting the degradation rate of SSZ in the UV/PDS process. Increasing the dosage of PDS significantly enhanced the degradation of SSZ in the UV/PDS process, which can be well predicted by the developed kinetic model. Natural water constituents, such as natural organic matter (NOM) and bicarbonate (HCO3-), influenced the degradation of SSZ differently. The azo functional group of SSZ molecule was predicted as the reactive site susceptible to electrophilic attack by SO4•- by frontier electron densities (FEDs) calculations. Four intermediate products arising from azo bond cleavage and SO2 extrusion were identified by solid phase extraction-liquid chromatography-triple quadrupole mass spectrometry (SPE-LC-MS/MS). Based on the products identified, detailed transformation pathways for SSZ degradation in the UV/PDS system were proposed. Results reveal that UV/PDS could be an efficient approach for remediation of water contaminated by SSZ and its metabolites. SN - 1879-2448 UR - https://www.unboundmedicine.com/medline/citation/29407711/Photodegradation_of_sulfasalazine_and_its_human_metabolites_in_water_by_UV_and_UV/peroxydisulfate_processes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0043-1354(18)30061-7 DB - PRIME DP - Unbound Medicine ER -