Tags

Type your tag names separated by a space and hit enter

Consensus of the role and positioning of the imidazoles in the treatment of dermatophytosis.

Abstract

The imidazoles have been appreciated for approximately fifteen years as a family of antifungals. Most derivatives, like the protype compounds, miconazole and clotrimazole, are effective only in a topical dose form. The topical imidazoles are generally thought to be superior to other topical antifungals. The first orally available imidazole, ketoconazole has ushered in a new era of potent, oral, broad-spectrum antifungal therapy. The imidazoles as a class are the treatment of choice for four dermatophyte infection syndromes. They are the preferred alternative therapy in another six syndromes. There is insufficient data to recommend one topical azole over the other. The topicals are inadequate for control of six clinical-anatomical infection syndromes. Griseofulvin remains the standard oral therapy in all situations except chronic, extensive dermatophytosis, where ketoconazole has proven to be more efficacious. The recognition of potential significant adverse effects, namely an idiopathic hepatitis and dose-dependent adrenal and testicular dysfunction have reduced ketoconazole's potential role in the dermatophytoses. Ketoconazole is a useful alternative to griseofulvin when oral therapy is required and the causative organism is insensitive to griseofulvin, or infection fails to respond to griseofulvin, or griseofulvin is contraindicated due to allergy, photosensitivity, porphyrinuria, intolerance, etc.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2940792

Citation

Jones, H E.. "Consensus of the Role and Positioning of the Imidazoles in the Treatment of Dermatophytosis." Acta Dermato-venereologica. Supplementum, vol. 121, 1986, pp. 139-46.
Jones HE. Consensus of the role and positioning of the imidazoles in the treatment of dermatophytosis. Acta Derm Venereol Suppl (Stockh). 1986;121:139-46.
Jones, H. E. (1986). Consensus of the role and positioning of the imidazoles in the treatment of dermatophytosis. Acta Dermato-venereologica. Supplementum, 121, 139-46.
Jones HE. Consensus of the Role and Positioning of the Imidazoles in the Treatment of Dermatophytosis. Acta Derm Venereol Suppl (Stockh). 1986;121:139-46. PubMed PMID: 2940792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consensus of the role and positioning of the imidazoles in the treatment of dermatophytosis. A1 - Jones,H E, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 139 EP - 46 JF - Acta dermato-venereologica. Supplementum JO - Acta Derm Venereol Suppl (Stockh) VL - 121 N2 - The imidazoles have been appreciated for approximately fifteen years as a family of antifungals. Most derivatives, like the protype compounds, miconazole and clotrimazole, are effective only in a topical dose form. The topical imidazoles are generally thought to be superior to other topical antifungals. The first orally available imidazole, ketoconazole has ushered in a new era of potent, oral, broad-spectrum antifungal therapy. The imidazoles as a class are the treatment of choice for four dermatophyte infection syndromes. They are the preferred alternative therapy in another six syndromes. There is insufficient data to recommend one topical azole over the other. The topicals are inadequate for control of six clinical-anatomical infection syndromes. Griseofulvin remains the standard oral therapy in all situations except chronic, extensive dermatophytosis, where ketoconazole has proven to be more efficacious. The recognition of potential significant adverse effects, namely an idiopathic hepatitis and dose-dependent adrenal and testicular dysfunction have reduced ketoconazole's potential role in the dermatophytoses. Ketoconazole is a useful alternative to griseofulvin when oral therapy is required and the causative organism is insensitive to griseofulvin, or infection fails to respond to griseofulvin, or griseofulvin is contraindicated due to allergy, photosensitivity, porphyrinuria, intolerance, etc. SN - 0365-8341 UR - https://www.unboundmedicine.com/medline/citation/2940792/Consensus_of_the_role_and_positioning_of_the_imidazoles_in_the_treatment_of_dermatophytosis_ DB - PRIME DP - Unbound Medicine ER -