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Prevalence of hepatitis E virus RNA and antibodies in a cohort of kidney transplant recipients in Central Brazil.
Int J Infect Dis. 2018 Apr; 69:41-43.IJ

Abstract

OBJECTIVE

To assess the prevalence of hepatitis E virus (HEV) RNA and antibodies among kidney transplant recipients (KTR) in Central Brazil. The presence of chronic HEV infection was also investigated.

METHODS

A cohort study was conducted among 316 KTR treated at a referral center for kidney transplantation in Goiânia, Brazil. All serum samples were tested for the presence of HEV RNA (real-time PCR) and anti-HEV IgG/IgM (ELISA). Anti-HEV-positive samples were confirmed using an immunoblot test. HEV chronicity was investigated in a subgroup of patients with elevated alanine aminotransferase (ALT >40IU/l) through HEV RNA detection in additional serum samples collected 3 and 6 months apart.

RESULTS

A seroprevalence of 2.5% (95% confidence interval 1.2-5.1%) was found for anti-HEV IgG. There was no difference in characteristics between the anti-HEV IgG seropositive and seronegative KTR groups. Anti-HEV IgM was detected in only one patient (0.3%). All KTR were negative for HEV RNA.

CONCLUSIONS

These results show that HEV infection is infrequent in KTR in Central Brazil, with low seroprevalence rates of past and recent infection, and also an absence of active and chronic HEV infections.

Authors+Show Affiliations

Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil.Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil.Faculty of Nursing, Federal University of Goiás, Goiânia, Goiás, Brazil.Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil. Electronic address: rbringel.iptsp.ufg@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29408465

Citation

de Oliveira, Jerusa Marielle Nunes Seabra, et al. "Prevalence of Hepatitis E Virus RNA and Antibodies in a Cohort of Kidney Transplant Recipients in Central Brazil." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 69, 2018, pp. 41-43.
de Oliveira JMNS, Freitas NR, Teles SA, et al. Prevalence of hepatitis E virus RNA and antibodies in a cohort of kidney transplant recipients in Central Brazil. Int J Infect Dis. 2018;69:41-43.
de Oliveira, J. M. N. S., Freitas, N. R., Teles, S. A., Bottino, F. O., Lemos, A. S., de Oliveira, J. M., de Paula, V., Pinto, M. A., & Martins, R. M. B. (2018). Prevalence of hepatitis E virus RNA and antibodies in a cohort of kidney transplant recipients in Central Brazil. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 69, 41-43. https://doi.org/10.1016/j.ijid.2018.01.032
de Oliveira JMNS, et al. Prevalence of Hepatitis E Virus RNA and Antibodies in a Cohort of Kidney Transplant Recipients in Central Brazil. Int J Infect Dis. 2018;69:41-43. PubMed PMID: 29408465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of hepatitis E virus RNA and antibodies in a cohort of kidney transplant recipients in Central Brazil. AU - de Oliveira,Jerusa Marielle Nunes Seabra, AU - Freitas,Nara Rubia de, AU - Teles,Sheila Araújo, AU - Bottino,Fernanda de Oliveira, AU - Lemos,Andreza Sálvio, AU - de Oliveira,Jaqueline Mendes, AU - de Paula,Vanessa, AU - Pinto,Marcelo Alves, AU - Martins,Regina Maria Bringel, Y1 - 2018/02/10/ PY - 2017/12/15/received PY - 2018/01/24/revised PY - 2018/01/27/accepted PY - 2018/2/7/pubmed PY - 2018/9/25/medline PY - 2018/2/7/entrez KW - Brazil KW - Hepatitis E virus KW - Kidney transplant recipients KW - Prevalence SP - 41 EP - 43 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 69 N2 - OBJECTIVE: To assess the prevalence of hepatitis E virus (HEV) RNA and antibodies among kidney transplant recipients (KTR) in Central Brazil. The presence of chronic HEV infection was also investigated. METHODS: A cohort study was conducted among 316 KTR treated at a referral center for kidney transplantation in Goiânia, Brazil. All serum samples were tested for the presence of HEV RNA (real-time PCR) and anti-HEV IgG/IgM (ELISA). Anti-HEV-positive samples were confirmed using an immunoblot test. HEV chronicity was investigated in a subgroup of patients with elevated alanine aminotransferase (ALT >40IU/l) through HEV RNA detection in additional serum samples collected 3 and 6 months apart. RESULTS: A seroprevalence of 2.5% (95% confidence interval 1.2-5.1%) was found for anti-HEV IgG. There was no difference in characteristics between the anti-HEV IgG seropositive and seronegative KTR groups. Anti-HEV IgM was detected in only one patient (0.3%). All KTR were negative for HEV RNA. CONCLUSIONS: These results show that HEV infection is infrequent in KTR in Central Brazil, with low seroprevalence rates of past and recent infection, and also an absence of active and chronic HEV infections. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/29408465/Prevalence_of_hepatitis_E_virus_RNA_and_antibodies_in_a_cohort_of_kidney_transplant_recipients_in_Central_Brazil_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(18)30033-X DB - PRIME DP - Unbound Medicine ER -