Changes in intermediate metabolism and oxidative balance parameters in sexually matured three-barbeled catfishes exposed to herbicides from rice crops (Roundup®, Primoleo® and Facet®).Environ Toxicol Pharmacol. 2018 Mar; 58:170-179.ET
This study analyzed the effect of different concentrations of herbicides (Facet®, Primoleo®, and Roundup®) on metabolism and oxidative balance (superoxide dismutase and catalase activity, lipid peroxidation) in the gills, liver, kidneys, and tail muscle of adult catfish. All herbicides caused protein depletion in gills, increased glycogen and triacylglycerol consumption in the liver, and changes in muscle glycogen. Roundup® and Primoleo® stimulated lipid deposition in the liver, while Roundup® and Facet® stimulated lipid consumption in gills. In kidneys, protein content increased after Roundup® and Primoleo® exposure, glycogen increased after Facet®, and lipids increased after Roundup®. Primoleo® had the strongest effect on muscle, with changes in all metabolites. Regarding oxidative stress, the liver and kidneys were the organs most affected by exposure to herbicides, and catalase was the main enzyme involved in the detoxification of these herbicides. A hierarchy of toxicity was established for the tested chemicals: Facet® > Primoleo® > Roundup®.