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Origin and dispersal of Hepatitis E virus.
Emerg Microbes Infect. 2018 Feb 07; 7(1):11.EM

Abstract

Hepatitis E virus (HEV, genus Orthohepevirus) is a common cause of hepatitis worldwide. Human-infecting HEV strains (Orthohepevirus A) include human-restricted and enzootic genotypes. Viruses in the Orthohepevirus A species also infect rabbits (HEV-3ra), camels, and swine. Using a selection-informed method, we dated the origin of the Orthohepevirus genus at least 21 million years ago, whereas the Orthohepevirus A species originated in Asia, most likely from a human-infecting ancestor that existed ~4500 to 6800 years ago. In this period, the appearance of large human settlements probably facilitated HEV emergence and spread. The earliest events in Orthohepevirus A evolutionary history involved the separation of the enzootic and human-restricted genotypes, as well as the split of the camel-infecting genotypes, which occurred during the time-frame of camel domestication. The place and timing of HEV-3ra divergence also correspond to the circumstances of rabbit domestication. This study clarifies the origin and historical events underlying HEV dispersal.

Authors+Show Affiliations

Scientific Institute IRCCS E. MEDEA, Bosisio Parini, 23842, Italy. diego.forni@bp.lnf.it.Scientific Institute IRCCS E. MEDEA, Bosisio Parini, 23842, Italy.Department of Pathophysiology and Transplantation, University of Milan, Milan, 20090, Italy. Don C. Gnocchi Foundation ONLUS, IRCCS, Milan, 20148, Italy.Scientific Institute IRCCS E. MEDEA, Bosisio Parini, 23842, Italy.

Pub Type(s)

Historical Article
Journal Article

Language

eng

PubMed ID

29410449

Citation

Forni, Diego, et al. "Origin and Dispersal of Hepatitis E Virus." Emerging Microbes & Infections, vol. 7, no. 1, 2018, p. 11.
Forni D, Cagliani R, Clerici M, et al. Origin and dispersal of Hepatitis E virus. Emerg Microbes Infect. 2018;7(1):11.
Forni, D., Cagliani, R., Clerici, M., & Sironi, M. (2018). Origin and dispersal of Hepatitis E virus. Emerging Microbes & Infections, 7(1), 11. https://doi.org/10.1038/s41426-017-0009-6
Forni D, et al. Origin and Dispersal of Hepatitis E Virus. Emerg Microbes Infect. 2018 Feb 7;7(1):11. PubMed PMID: 29410449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Origin and dispersal of Hepatitis E virus. AU - Forni,Diego, AU - Cagliani,Rachele, AU - Clerici,Mario, AU - Sironi,Manuela, Y1 - 2018/02/07/ PY - 2017/09/07/received PY - 2017/12/03/accepted PY - 2017/11/17/revised PY - 2018/2/8/entrez PY - 2018/2/8/pubmed PY - 2018/11/16/medline SP - 11 EP - 11 JF - Emerging microbes & infections JO - Emerg Microbes Infect VL - 7 IS - 1 N2 - Hepatitis E virus (HEV, genus Orthohepevirus) is a common cause of hepatitis worldwide. Human-infecting HEV strains (Orthohepevirus A) include human-restricted and enzootic genotypes. Viruses in the Orthohepevirus A species also infect rabbits (HEV-3ra), camels, and swine. Using a selection-informed method, we dated the origin of the Orthohepevirus genus at least 21 million years ago, whereas the Orthohepevirus A species originated in Asia, most likely from a human-infecting ancestor that existed ~4500 to 6800 years ago. In this period, the appearance of large human settlements probably facilitated HEV emergence and spread. The earliest events in Orthohepevirus A evolutionary history involved the separation of the enzootic and human-restricted genotypes, as well as the split of the camel-infecting genotypes, which occurred during the time-frame of camel domestication. The place and timing of HEV-3ra divergence also correspond to the circumstances of rabbit domestication. This study clarifies the origin and historical events underlying HEV dispersal. SN - 2222-1751 UR - https://www.unboundmedicine.com/medline/citation/29410449/Origin_and_dispersal_of_Hepatitis_E_virus_ L2 - https://www.tandfonline.com/doi/full/10.1038/s41426-017-0009-6 DB - PRIME DP - Unbound Medicine ER -