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CAIDE Dementia Risk Score, Alzheimer and cerebrovascular pathology: a population-based autopsy study.
J Intern Med. 2018 06; 283(6):597-603.JI

Abstract

BACKGROUND

CAIDE Dementia Risk Score is a tool for estimating dementia risk in the general population. Its longitudinal associations with Alzheimer or vascular neuropathology in the oldest old are not known.

AIM

To explore the relationship between CAIDE Dementia Risk Score at baseline and neuritic plaques, neurofibrillary tangles, cerebral infarcts and cerebral amyloid angiopathy (CAA) after up to 10-year follow-up in the Vantaa 85 + population.

METHODS

Study population included 149 participants aged ≥85 years, without dementia at baseline, and with available clinical and autopsy data. Methenamine silver staining was used for β-amyloid and modified Bielschowsky method for neurofibrillary tangles and neuritic plaques. Macroscopic infarcts were identified from cerebral hemispheres, brainstem and cerebellum slices. Standardized methods were used to determine microscopic infarcts, CAA and α-synuclein pathologies. The CAIDE Dementia Risk Score was calculated based on scores for age, sex, BMI, total cholesterol, systolic blood pressure, physical activity and APOEε4 carrier status (range 0-18 points).

RESULTS

A CAIDE Dementia Risk Score above 11 points was associated with more cerebral infarctions up to 10 years later: OR (95% CI) was 2.10 (1.06-4.16). No associations were found with other neuropathologies.

CONCLUSION

In a population of elderly aged ≥85 years, higher CAIDE Dementia Risk Score was associated with increased risk of cerebral infarcts.

Authors+Show Affiliations

Aging Research Center, Karolinska Institute, Stockholm, Sweden. Department of Neurology, Ulm University Hospital, Ulm, Germany.Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institute, Stockholm, Sweden. Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland. Department of Geriatrics, Karolinska University Hospital, Stockholm, Sweden. Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK.Department of Pathology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institute, Stockholm, Sweden.Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institute, Stockholm, Sweden.Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institute, Stockholm, Sweden.Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institute, Stockholm, Sweden.Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institute, Stockholm, Sweden. Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland. Department of Geriatrics, Karolinska University Hospital, Stockholm, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29411449

Citation

Hooshmand, B, et al. "CAIDE Dementia Risk Score, Alzheimer and Cerebrovascular Pathology: a Population-based Autopsy Study." Journal of Internal Medicine, vol. 283, no. 6, 2018, pp. 597-603.
Hooshmand B, Polvikoski T, Kivipelto M, et al. CAIDE Dementia Risk Score, Alzheimer and cerebrovascular pathology: a population-based autopsy study. J Intern Med. 2018;283(6):597-603.
Hooshmand, B., Polvikoski, T., Kivipelto, M., Tanskanen, M., Myllykangas, L., Mäkelä, M., Oinas, M., Paetau, A., & Solomon, A. (2018). CAIDE Dementia Risk Score, Alzheimer and cerebrovascular pathology: a population-based autopsy study. Journal of Internal Medicine, 283(6), 597-603. https://doi.org/10.1111/joim.12736
Hooshmand B, et al. CAIDE Dementia Risk Score, Alzheimer and Cerebrovascular Pathology: a Population-based Autopsy Study. J Intern Med. 2018;283(6):597-603. PubMed PMID: 29411449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CAIDE Dementia Risk Score, Alzheimer and cerebrovascular pathology: a population-based autopsy study. AU - Hooshmand,B, AU - Polvikoski,T, AU - Kivipelto,M, AU - Tanskanen,M, AU - Myllykangas,L, AU - Mäkelä,M, AU - Oinas,M, AU - Paetau,A, AU - Solomon,A, Y1 - 2018/03/14/ PY - 2018/2/8/pubmed PY - 2019/9/17/medline PY - 2018/2/8/entrez KW - Alzheimer pathology KW - CAIDE Dementia Risk Score KW - cerebrovascular pathology KW - dementia KW - elderly SP - 597 EP - 603 JF - Journal of internal medicine JO - J. Intern. Med. VL - 283 IS - 6 N2 - BACKGROUND: CAIDE Dementia Risk Score is a tool for estimating dementia risk in the general population. Its longitudinal associations with Alzheimer or vascular neuropathology in the oldest old are not known. AIM: To explore the relationship between CAIDE Dementia Risk Score at baseline and neuritic plaques, neurofibrillary tangles, cerebral infarcts and cerebral amyloid angiopathy (CAA) after up to 10-year follow-up in the Vantaa 85 + population. METHODS: Study population included 149 participants aged ≥85 years, without dementia at baseline, and with available clinical and autopsy data. Methenamine silver staining was used for β-amyloid and modified Bielschowsky method for neurofibrillary tangles and neuritic plaques. Macroscopic infarcts were identified from cerebral hemispheres, brainstem and cerebellum slices. Standardized methods were used to determine microscopic infarcts, CAA and α-synuclein pathologies. The CAIDE Dementia Risk Score was calculated based on scores for age, sex, BMI, total cholesterol, systolic blood pressure, physical activity and APOEε4 carrier status (range 0-18 points). RESULTS: A CAIDE Dementia Risk Score above 11 points was associated with more cerebral infarctions up to 10 years later: OR (95% CI) was 2.10 (1.06-4.16). No associations were found with other neuropathologies. CONCLUSION: In a population of elderly aged ≥85 years, higher CAIDE Dementia Risk Score was associated with increased risk of cerebral infarcts. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/29411449/CAIDE_Dementia_Risk_Score_Alzheimer_and_cerebrovascular_pathology:_a_population_based_autopsy_study_ L2 - https://doi.org/10.1111/joim.12736 DB - PRIME DP - Unbound Medicine ER -