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Beneficial Effects of Flavonoids Against Parkinson's Disease.
J Med Food. 2018 May; 21(5):421-432.JM

Abstract

Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta and decreases in striatal dopamine levels. These changes led to several clinical symptoms: rigidity, resting tremor, and bradykinesia. Although the cause of PD remains unclear, it is widely accepted that oxidative stress, neuroinflammation, mitochondrial dysfunction, and insufficient support of neurotrophic factors are involved in the pathophysiology of the disease. However, novel regimens to prevent neurodegeneration and restore the degenerated nigrostriatal DA system are still required. In recent years, there has been a growing interest in naturally occurring phytochemicals, which are believed to reduce the risk of neurodegenerative diseases. This review provides an overview of the scientific literature concerning the preventive and protective roles of flavonoids, one of the largest families of phytochemicals, against PD. In addition to providing antioxidant and anti-inflammatory effects, flavonoids exhibit a neuroprotective effect by activating antiapoptotic pathways that target mitochondrial dysfunction and induce neurotrophic factors. This review suggests that flavonoids may be promising natural products for the prevention of PD and could potentially be utilized as therapeutic compounds against PD, even though there was no report showing that the treatment with flavonoids could restore the aberrant phenotypes of patients with PD.

Authors+Show Affiliations

1 Department of Food Science and Nutrition, Pukyong National University , Busan, Korea.2 School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Institute of Life Science and Biotechnology, Kyungpook National University , Daegu, Korea. 3 Brain Science and Engineering Institute, Kyungpook National University , Daegu, Korea.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29412767

Citation

Jung, Un Ju, and Sang Ryong Kim. "Beneficial Effects of Flavonoids Against Parkinson's Disease." Journal of Medicinal Food, vol. 21, no. 5, 2018, pp. 421-432.
Jung UJ, Kim SR. Beneficial Effects of Flavonoids Against Parkinson's Disease. J Med Food. 2018;21(5):421-432.
Jung, U. J., & Kim, S. R. (2018). Beneficial Effects of Flavonoids Against Parkinson's Disease. Journal of Medicinal Food, 21(5), 421-432. https://doi.org/10.1089/jmf.2017.4078
Jung UJ, Kim SR. Beneficial Effects of Flavonoids Against Parkinson's Disease. J Med Food. 2018;21(5):421-432. PubMed PMID: 29412767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial Effects of Flavonoids Against Parkinson's Disease. AU - Jung,Un Ju, AU - Kim,Sang Ryong, Y1 - 2018/02/07/ PY - 2018/2/8/pubmed PY - 2018/10/30/medline PY - 2018/2/8/entrez KW - Parkinson's disease KW - flavonoids KW - neuroprotection SP - 421 EP - 432 JF - Journal of medicinal food JO - J Med Food VL - 21 IS - 5 N2 - Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta and decreases in striatal dopamine levels. These changes led to several clinical symptoms: rigidity, resting tremor, and bradykinesia. Although the cause of PD remains unclear, it is widely accepted that oxidative stress, neuroinflammation, mitochondrial dysfunction, and insufficient support of neurotrophic factors are involved in the pathophysiology of the disease. However, novel regimens to prevent neurodegeneration and restore the degenerated nigrostriatal DA system are still required. In recent years, there has been a growing interest in naturally occurring phytochemicals, which are believed to reduce the risk of neurodegenerative diseases. This review provides an overview of the scientific literature concerning the preventive and protective roles of flavonoids, one of the largest families of phytochemicals, against PD. In addition to providing antioxidant and anti-inflammatory effects, flavonoids exhibit a neuroprotective effect by activating antiapoptotic pathways that target mitochondrial dysfunction and induce neurotrophic factors. This review suggests that flavonoids may be promising natural products for the prevention of PD and could potentially be utilized as therapeutic compounds against PD, even though there was no report showing that the treatment with flavonoids could restore the aberrant phenotypes of patients with PD. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/29412767/Beneficial_Effects_of_Flavonoids_Against_Parkinson's_Disease_ L2 - https://www.liebertpub.com/doi/10.1089/jmf.2017.4078?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -