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Disparities in severe shigellosis among adults - Foodborne diseases active surveillance network, 2002-2014.
BMC Public Health. 2018 02 07; 18(1):221.BP

Abstract

BACKGROUND

Shigella causes approximately 500,000 illnesses, 6000 hospitalizations, and 40 deaths in the United States annually, but incidence and populations at risk for severe shigellosis among adults are unclear. This study describes severe shigellosis among US adults.

METHODS

We analyzed Foodborne Diseases Active Surveillance Network data for infections caused by Shigella among adults ≥18 years old during 2002-2014. Criteria to define severe shigellosis included hospitalization, bacteremia, or death. We estimated annual incidence of shigellosis per 100,000 among adult populations, and conducted multivariable mixed-effects logistic regression to assess associations between severe shigellosis, demographic factors and Shigella species among adults with shigellosis.

RESULTS

Among 9968 shigellosis cases, 2764 (28%) were severe. Restricting to cases due to S. sonnei and S. flexneri, median annual incidence of severe shigellosis among adults was 0.56 and highest overall incidence was among black males 18-49 years old (1.58). Among adults with shigellosis, odds of severe disease were higher among males than females aged 18-49 years old (OR [95% CI] = 1.32 [1.15-1.52], p < 0.001) and among males than females with S. flexneri infections (OR [95% CI] =1.39 [1.10-1.75], p = 0.005). The odds of severe shigellosis were higher among blacks than whites (OR [95% CI] = 1.36 [1.22-1.52], p < 0.001).

CONCLUSIONS

Among adults, men 18-49 years old, particularly blacks, have the highest incidence of severe shigellosis. Among adults with shigellosis, severe shigellosis was associated with being male in age group 18-49 years, with infections caused by S. flexneri, and with black race. Future research should assess associations between severe shigellosis and sexual practices, antimicrobial resistance, comorbidities, and access to care.

Authors+Show Affiliations

Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30333, USA. vjf4@cdc.gov.Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30333, USA.Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30333, USA.Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA, 30333, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29415691

Citation

McCrickard, Lindsey S., et al. "Disparities in Severe Shigellosis Among Adults - Foodborne Diseases Active Surveillance Network, 2002-2014." BMC Public Health, vol. 18, no. 1, 2018, p. 221.
McCrickard LS, Crim SM, Kim S, et al. Disparities in severe shigellosis among adults - Foodborne diseases active surveillance network, 2002-2014. BMC Public Health. 2018;18(1):221.
McCrickard, L. S., Crim, S. M., Kim, S., & Bowen, A. (2018). Disparities in severe shigellosis among adults - Foodborne diseases active surveillance network, 2002-2014. BMC Public Health, 18(1), 221. https://doi.org/10.1186/s12889-018-5115-4
McCrickard LS, et al. Disparities in Severe Shigellosis Among Adults - Foodborne Diseases Active Surveillance Network, 2002-2014. BMC Public Health. 2018 02 7;18(1):221. PubMed PMID: 29415691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disparities in severe shigellosis among adults - Foodborne diseases active surveillance network, 2002-2014. AU - McCrickard,Lindsey S, AU - Crim,Stacy M, AU - Kim,Sunkyung, AU - Bowen,Anna, Y1 - 2018/02/07/ PY - 2017/07/03/received PY - 2018/01/23/accepted PY - 2018/2/9/entrez PY - 2018/2/9/pubmed PY - 2018/6/19/medline KW - Adult KW - Epidemiology KW - MSM KW - Shigellosis SP - 221 EP - 221 JF - BMC public health JO - BMC Public Health VL - 18 IS - 1 N2 - BACKGROUND: Shigella causes approximately 500,000 illnesses, 6000 hospitalizations, and 40 deaths in the United States annually, but incidence and populations at risk for severe shigellosis among adults are unclear. This study describes severe shigellosis among US adults. METHODS: We analyzed Foodborne Diseases Active Surveillance Network data for infections caused by Shigella among adults ≥18 years old during 2002-2014. Criteria to define severe shigellosis included hospitalization, bacteremia, or death. We estimated annual incidence of shigellosis per 100,000 among adult populations, and conducted multivariable mixed-effects logistic regression to assess associations between severe shigellosis, demographic factors and Shigella species among adults with shigellosis. RESULTS: Among 9968 shigellosis cases, 2764 (28%) were severe. Restricting to cases due to S. sonnei and S. flexneri, median annual incidence of severe shigellosis among adults was 0.56 and highest overall incidence was among black males 18-49 years old (1.58). Among adults with shigellosis, odds of severe disease were higher among males than females aged 18-49 years old (OR [95% CI] = 1.32 [1.15-1.52], p < 0.001) and among males than females with S. flexneri infections (OR [95% CI] =1.39 [1.10-1.75], p = 0.005). The odds of severe shigellosis were higher among blacks than whites (OR [95% CI] = 1.36 [1.22-1.52], p < 0.001). CONCLUSIONS: Among adults, men 18-49 years old, particularly blacks, have the highest incidence of severe shigellosis. Among adults with shigellosis, severe shigellosis was associated with being male in age group 18-49 years, with infections caused by S. flexneri, and with black race. Future research should assess associations between severe shigellosis and sexual practices, antimicrobial resistance, comorbidities, and access to care. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/29415691/full_citation L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-018-5115-4 DB - PRIME DP - Unbound Medicine ER -