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Conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI): which is preferred for advanced age patients with five or fewer oocytes retrieved?
Arch Gynecol Obstet. 2018 May; 297(5):1301-1306.AG

Abstract

PURPOSE

To investigate the clinical outcomes of conventional IVF and ICSI in female patients aged 40 years and over with no more than five oocytes retrieved and non-male factor infertility.

METHODS

A retrospective study of a cohort of 644 patients undergoing IVF/ICSI treatment. The 534 female patients aged ≧ 40 years with no more than five oocytes retrieved and non-male factor infertility undergoing their first conventional IVF cycles were assigned in IVF group. The rest of 110 patients aged 40 years and over with no more than five oocytes retrieved and non-male factor infertility undergoing first ICSI cycles were recruited in ICSI group.

RESULTS

Our results showed the clinical pregnancy, live birth and miscarriage rates were similar between the IVF and ICSI groups (21.59% vs. 13.25%, P > 0.05; 12.16% vs. 6.02%, P > 0.05; 43.68% vs. 54.55%, P > 0.05; respectively), however, the implantation and cumulative live-birth rates were significantly higher in the IVF compared to the ICSI group (15.11% vs. 7.75%, 14.59% vs. 5.56%, P < 0.05), though the IVF group had a lower normal fertilization rate (61.56% vs. 76.00%, P < 0.001).

CONCLUSIONS

Our study provides strong evidences that the conventional IVF exhibits advantages over the ICSI method in non-male factor infertility for advanced age patients with five or fewer oocytes retrieved.

Authors+Show Affiliations

Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China.Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China.Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China.Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China.Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China.Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China.Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China. wukeliang_527@163.com. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, No. 157 Jingliu Road, Jinan, 250001, People's Republic of China. wukeliang_527@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29417282

Citation

Liu, Hui, et al. "Conventional in Vitro Fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI): Which Is Preferred for Advanced Age Patients With Five or Fewer Oocytes Retrieved?" Archives of Gynecology and Obstetrics, vol. 297, no. 5, 2018, pp. 1301-1306.
Liu H, Zhao H, Yu G, et al. Conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI): which is preferred for advanced age patients with five or fewer oocytes retrieved? Arch Gynecol Obstet. 2018;297(5):1301-1306.
Liu, H., Zhao, H., Yu, G., Li, M., Ma, S., Zhang, H., & Wu, K. (2018). Conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI): which is preferred for advanced age patients with five or fewer oocytes retrieved? Archives of Gynecology and Obstetrics, 297(5), 1301-1306. https://doi.org/10.1007/s00404-018-4696-6
Liu H, et al. Conventional in Vitro Fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI): Which Is Preferred for Advanced Age Patients With Five or Fewer Oocytes Retrieved. Arch Gynecol Obstet. 2018;297(5):1301-1306. PubMed PMID: 29417282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI): which is preferred for advanced age patients with five or fewer oocytes retrieved? AU - Liu,Hui, AU - Zhao,Haibin, AU - Yu,Guanling, AU - Li,Mei, AU - Ma,Shuiying, AU - Zhang,Haozhen, AU - Wu,Keliang, Y1 - 2018/02/07/ PY - 2017/09/21/received PY - 2018/01/25/accepted PY - 2018/2/9/pubmed PY - 2019/8/9/medline PY - 2018/2/9/entrez KW - Advanced-age female KW - Cumulative live birth rate KW - In vitro fertilization KW - Intracytoplasmic sperm injection KW - Non-male factor infertility SP - 1301 EP - 1306 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 297 IS - 5 N2 - PURPOSE: To investigate the clinical outcomes of conventional IVF and ICSI in female patients aged 40 years and over with no more than five oocytes retrieved and non-male factor infertility. METHODS: A retrospective study of a cohort of 644 patients undergoing IVF/ICSI treatment. The 534 female patients aged ≧ 40 years with no more than five oocytes retrieved and non-male factor infertility undergoing their first conventional IVF cycles were assigned in IVF group. The rest of 110 patients aged 40 years and over with no more than five oocytes retrieved and non-male factor infertility undergoing first ICSI cycles were recruited in ICSI group. RESULTS: Our results showed the clinical pregnancy, live birth and miscarriage rates were similar between the IVF and ICSI groups (21.59% vs. 13.25%, P > 0.05; 12.16% vs. 6.02%, P > 0.05; 43.68% vs. 54.55%, P > 0.05; respectively), however, the implantation and cumulative live-birth rates were significantly higher in the IVF compared to the ICSI group (15.11% vs. 7.75%, 14.59% vs. 5.56%, P < 0.05), though the IVF group had a lower normal fertilization rate (61.56% vs. 76.00%, P < 0.001). CONCLUSIONS: Our study provides strong evidences that the conventional IVF exhibits advantages over the ICSI method in non-male factor infertility for advanced age patients with five or fewer oocytes retrieved. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/29417282/Conventional_in_vitro_fertilization__IVF__or_intracytoplasmic_sperm_injection__ICSI_:_which_is_preferred_for_advanced_age_patients_with_five_or_fewer_oocytes_retrieved L2 - https://dx.doi.org/10.1007/s00404-018-4696-6 DB - PRIME DP - Unbound Medicine ER -