Tags

Type your tag names separated by a space and hit enter

Vitamin D and Subjective Memory Complaint in Community-Dwelling Older Adults.
Curr Alzheimer Res 2018; 15(7):664-670CA

Abstract

BACKGROUND

Older adults with hypovitaminosis D report more often subjective cognitive complaints, especially with regards to memory. This raises prospects that vitamin D may improve older adults' subjective experience of memory disorders.

OBJECTIVE

To determine among older community-dwellers whether higher serum 25- hydroxyvitamin D (25OHD) concentrations were associated with fewer memory complaints, while considering different subtypes of memory complaints.

METHOD

One hundred eighty Caucasian community-dwellers with memory complaint and no dementia (mean±standard deviation, 71.1±3.4years; 33.3%female) from the French 'EVATEM study' were included in this analysis. Subjective memory complaints regarding memory lapses, problems learning new information, problems finding words, problems calculating and problems concentrating were assessed using a standardized questionnaire. Participants were categorized according to the highest tertile of serum 25OHD (i.e., ≥68nmol/L). Age, gender, body mass index, morbidities burden, use of vitamin D supplements, cognitive performance, mood, serum concentrations of calcium, parathyroid hormone and vitamin B12, creatinine clearance, and season of evaluation were used as potential confounders.

RESULTS

Compared to participants with 25OHD<68nmol/L (n=121), those with 25OHD≥68nmol/L had less often problems learning new information (P=0.027). There were no between-group differences for the other memory complaints. The highest 25OHD tertile was cross-sectionally associated with fewer problems learning new information (odds ratio (OR)=0.48, P=0.029), even after adjustment for potential confounders (OR=0.32, P=0.039).

CONCLUSION

Higher vitamin D status was associated with reduced problems memorizing new information in older community-dwellers. This novel finding provides a scientific base for vitamin D replacement trials attempting to improve older patients' subjective experience of cognitive decline.

Authors+Show Affiliations

Department of Geriatric Medicine, University Memory Clinic, UPRES EA 4638, Angers University Hospital, Angers, France. Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada. School of Medicine, University of Angers, UNAM, Angers, France.School of Medicine, University of Angers, UNAM, Angers, France.School of Medicine, University of Angers, UNAM, Angers, France.School of Medicine, University of Angers, UNAM, Angers, France.Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.Department of Geriatric Medicine, University Memory Clinic, UPRES EA 4638, Angers University Hospital, Angers, France.Department of Geriatric Medicine, University Memory Clinic, UPRES EA 4638, Angers University Hospital, Angers, France.Department of Geriatric Medicine, University Memory Clinic, UPRES EA 4638, Angers University Hospital, Angers, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29422004

Citation

Annweiler, Cedric, et al. "Vitamin D and Subjective Memory Complaint in Community-Dwelling Older Adults." Current Alzheimer Research, vol. 15, no. 7, 2018, pp. 664-670.
Annweiler C, Doineau L, Gerigne L, et al. Vitamin D and Subjective Memory Complaint in Community-Dwelling Older Adults. Curr Alzheimer Res. 2018;15(7):664-670.
Annweiler, C., Doineau, L., Gerigne, L., Provendier, A., Karras, S. N., Beauchet, O., ... Duval, G. T. (2018). Vitamin D and Subjective Memory Complaint in Community-Dwelling Older Adults. Current Alzheimer Research, 15(7), pp. 664-670. doi:10.2174/1567205015666180201153735.
Annweiler C, et al. Vitamin D and Subjective Memory Complaint in Community-Dwelling Older Adults. Curr Alzheimer Res. 2018;15(7):664-670. PubMed PMID: 29422004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and Subjective Memory Complaint in Community-Dwelling Older Adults. AU - Annweiler,Cedric, AU - Doineau,Lise, AU - Gerigne,Lucie, AU - Provendier,Anais, AU - Karras,Spyridon N, AU - Beauchet,Olivier, AU - Fantino,Bruno, AU - Duval,Guillaume T, PY - 2017/04/28/received PY - 2018/01/08/revised PY - 2018/01/31/accepted PY - 2018/2/10/pubmed PY - 2019/5/14/medline PY - 2018/2/10/entrez KW - Cognition KW - dementia KW - learning KW - neuroendocrinology KW - older adults KW - subjective memory complaint KW - vitamin D. SP - 664 EP - 670 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 15 IS - 7 N2 - BACKGROUND: Older adults with hypovitaminosis D report more often subjective cognitive complaints, especially with regards to memory. This raises prospects that vitamin D may improve older adults' subjective experience of memory disorders. OBJECTIVE: To determine among older community-dwellers whether higher serum 25- hydroxyvitamin D (25OHD) concentrations were associated with fewer memory complaints, while considering different subtypes of memory complaints. METHOD: One hundred eighty Caucasian community-dwellers with memory complaint and no dementia (mean±standard deviation, 71.1±3.4years; 33.3%female) from the French 'EVATEM study' were included in this analysis. Subjective memory complaints regarding memory lapses, problems learning new information, problems finding words, problems calculating and problems concentrating were assessed using a standardized questionnaire. Participants were categorized according to the highest tertile of serum 25OHD (i.e., ≥68nmol/L). Age, gender, body mass index, morbidities burden, use of vitamin D supplements, cognitive performance, mood, serum concentrations of calcium, parathyroid hormone and vitamin B12, creatinine clearance, and season of evaluation were used as potential confounders. RESULTS: Compared to participants with 25OHD<68nmol/L (n=121), those with 25OHD≥68nmol/L had less often problems learning new information (P=0.027). There were no between-group differences for the other memory complaints. The highest 25OHD tertile was cross-sectionally associated with fewer problems learning new information (odds ratio (OR)=0.48, P=0.029), even after adjustment for potential confounders (OR=0.32, P=0.039). CONCLUSION: Higher vitamin D status was associated with reduced problems memorizing new information in older community-dwellers. This novel finding provides a scientific base for vitamin D replacement trials attempting to improve older patients' subjective experience of cognitive decline. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/29422004/Vitamin_D_and_Subjective_Memory_Complaint_in_Community_Dwelling_Older_Adults_ L2 - http://www.eurekaselect.com/159553/article DB - PRIME DP - Unbound Medicine ER -