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Multifocal Spinal Cord Nephroblastoma in a Dog.
J Comp Pathol. 2018 Jan; 158:12-16.JC

Abstract

A 1-year-old male American pit bull terrier was presented with a history of proprioceptive deficits and mild lameness of the right hindlimb, which progressed after 5 months to paraparesis, culminating in tetraparesis after 2 weeks. Necropsy findings were limited to the spinal cord and consisted of multiple, intradural, extramedullary, slightly red masses which produced segmental areas of medullary swelling located in the cervical intumescence, thoracolumbar column, sacral segment and cauda equina. Histological evaluation revealed a tumour, composed of epithelial, stromal and blastemal cells, with structures resembling tubules, acini and embryonic glomeruli. Immunohistochemical labelling for vimentin, cytokeratin and S100 was positive for the stromal, epithelial and blastemal cells, respectively. A final diagnosis of multifocal spinal cord nephroblastoma was established. This is the first report of such a tumour showing concomitant involvement of the cervicothoracic, thoracolumbar, sacral and cauda equina areas of the spinal cord.

Authors+Show Affiliations

Department of Veterinary Pathology, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9090 Pr. 42505, Porto Alegre, Brazil. Electronic address: henkerluan@hotmail.com.Department of Veterinary Pathology, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9090 Pr. 42505, Porto Alegre, Brazil.Department of Veterinary Pathology, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9090 Pr. 42505, Porto Alegre, Brazil.Universidade de Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul, Brazil.Department of Veterinary Pathology, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9090 Pr. 42505, Porto Alegre, Brazil.Department of Veterinary Pathology, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9090 Pr. 42505, Porto Alegre, Brazil.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29422310

Citation

Henker, L C., et al. "Multifocal Spinal Cord Nephroblastoma in a Dog." Journal of Comparative Pathology, vol. 158, 2018, pp. 12-16.
Henker LC, Bianchi RM, Vargas TP, et al. Multifocal Spinal Cord Nephroblastoma in a Dog. J Comp Pathol. 2018;158:12-16.
Henker, L. C., Bianchi, R. M., Vargas, T. P., de Oliveira, E. C., Driemeier, D., & Pavarini, S. P. (2018). Multifocal Spinal Cord Nephroblastoma in a Dog. Journal of Comparative Pathology, 158, 12-16. https://doi.org/10.1016/j.jcpa.2017.10.176
Henker LC, et al. Multifocal Spinal Cord Nephroblastoma in a Dog. J Comp Pathol. 2018;158:12-16. PubMed PMID: 29422310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multifocal Spinal Cord Nephroblastoma in a Dog. AU - Henker,L C, AU - Bianchi,R M, AU - Vargas,T P, AU - de Oliveira,E C, AU - Driemeier,D, AU - Pavarini,S P, Y1 - 2017/12/01/ PY - 2017/08/11/received PY - 2017/10/23/revised PY - 2017/10/30/accepted PY - 2018/2/10/entrez PY - 2018/2/10/pubmed PY - 2018/8/22/medline KW - Wilms tumour KW - dog KW - immunohistochemistry KW - spinal cord SP - 12 EP - 16 JF - Journal of comparative pathology JO - J. Comp. Pathol. VL - 158 N2 - A 1-year-old male American pit bull terrier was presented with a history of proprioceptive deficits and mild lameness of the right hindlimb, which progressed after 5 months to paraparesis, culminating in tetraparesis after 2 weeks. Necropsy findings were limited to the spinal cord and consisted of multiple, intradural, extramedullary, slightly red masses which produced segmental areas of medullary swelling located in the cervical intumescence, thoracolumbar column, sacral segment and cauda equina. Histological evaluation revealed a tumour, composed of epithelial, stromal and blastemal cells, with structures resembling tubules, acini and embryonic glomeruli. Immunohistochemical labelling for vimentin, cytokeratin and S100 was positive for the stromal, epithelial and blastemal cells, respectively. A final diagnosis of multifocal spinal cord nephroblastoma was established. This is the first report of such a tumour showing concomitant involvement of the cervicothoracic, thoracolumbar, sacral and cauda equina areas of the spinal cord. SN - 1532-3129 UR - https://www.unboundmedicine.com/medline/citation/29422310/Multifocal_Spinal_Cord_Nephroblastoma_in_a_Dog L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9975(17)30302-X DB - PRIME DP - Unbound Medicine ER -