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Metachronous metastatic colonic small cell carcinoma and recurrent adenocarcinoma in a patient with ulcerative colitis.
J Surg Case Rep 2017; 2017(10):rjx201JS

Abstract

Colonic small cell carcinomas (SCCs) are rare, aggressive tumors characterized by early metastasis and poor prognosis. We describe a 39-year-old man with a history of ulcerative colitis and left colon adenocarcinoma resected at an outside institution who presented with hematochezia and proctalgia. Work-up revealed left colon SCC with liver metastases. After his excellent response to neoadjuvant chemotherapy, we performed synchronous proctocolectomy and right hepatectomy. Final pathologic evaluation revealed colonic primary SCC and recurrent adenocarcinoma with metastatic SCC to the liver; lymph nodes were positive for metastatic SCC and adenocarcinoma. SCC recurrence ultimately developed in the liver. To the best of our knowledge, this is the second reported case of surgical management of SCC of the colon with liver metastasis and the first report of synchronous excision. Despite superb response to neoadjuvant therapy and young patient age, caution is needed in surgical resection for SCC of the colon given the high recurrence risk.

Authors+Show Affiliations

Department of Surgery (Dr. Elias, M.D. and Dr. Colibaseanu, M.D.) and Division of Transplant Surgery (Dr. Croome, M.D.), Mayo Clinic, Jacksonville, FL, USA.Department of Surgery (Dr. Elias, M.D. and Dr. Colibaseanu, M.D.) and Division of Transplant Surgery (Dr. Croome, M.D.), Mayo Clinic, Jacksonville, FL, USA.Department of Surgery (Dr. Elias, M.D. and Dr. Colibaseanu, M.D.) and Division of Transplant Surgery (Dr. Croome, M.D.), Mayo Clinic, Jacksonville, FL, USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

29423143

Citation

Elias, Alexandra W., et al. "Metachronous Metastatic Colonic Small Cell Carcinoma and Recurrent Adenocarcinoma in a Patient With Ulcerative Colitis." Journal of Surgical Case Reports, vol. 2017, no. 10, 2017, pp. rjx201.
Elias AW, Colibaseanu DT, Croome KP. Metachronous metastatic colonic small cell carcinoma and recurrent adenocarcinoma in a patient with ulcerative colitis. J Surg Case Rep. 2017;2017(10):rjx201.
Elias, A. W., Colibaseanu, D. T., & Croome, K. P. (2017). Metachronous metastatic colonic small cell carcinoma and recurrent adenocarcinoma in a patient with ulcerative colitis. Journal of Surgical Case Reports, 2017(10), pp. rjx201. doi:10.1093/jscr/rjx201.
Elias AW, Colibaseanu DT, Croome KP. Metachronous Metastatic Colonic Small Cell Carcinoma and Recurrent Adenocarcinoma in a Patient With Ulcerative Colitis. J Surg Case Rep. 2017;2017(10):rjx201. PubMed PMID: 29423143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metachronous metastatic colonic small cell carcinoma and recurrent adenocarcinoma in a patient with ulcerative colitis. AU - Elias,Alexandra W, AU - Colibaseanu,Dorin T, AU - Croome,Kristopher P, Y1 - 2017/10/20/ PY - 2017/06/07/received PY - 2017/09/12/revised PY - 2017/09/28/accepted PY - 2018/2/10/entrez PY - 2018/2/10/pubmed PY - 2018/2/10/medline SP - rjx201 EP - rjx201 JF - Journal of surgical case reports JO - J Surg Case Rep VL - 2017 IS - 10 N2 - Colonic small cell carcinomas (SCCs) are rare, aggressive tumors characterized by early metastasis and poor prognosis. We describe a 39-year-old man with a history of ulcerative colitis and left colon adenocarcinoma resected at an outside institution who presented with hematochezia and proctalgia. Work-up revealed left colon SCC with liver metastases. After his excellent response to neoadjuvant chemotherapy, we performed synchronous proctocolectomy and right hepatectomy. Final pathologic evaluation revealed colonic primary SCC and recurrent adenocarcinoma with metastatic SCC to the liver; lymph nodes were positive for metastatic SCC and adenocarcinoma. SCC recurrence ultimately developed in the liver. To the best of our knowledge, this is the second reported case of surgical management of SCC of the colon with liver metastasis and the first report of synchronous excision. Despite superb response to neoadjuvant therapy and young patient age, caution is needed in surgical resection for SCC of the colon given the high recurrence risk. SN - 2042-8812 UR - https://www.unboundmedicine.com/medline/citation/29423143/Metachronous_metastatic_colonic_small_cell_carcinoma_and_recurrent_adenocarcinoma_in_a_patient_with_ulcerative_colitis L2 - https://academic.oup.com/jscr/article-lookup/doi/10.1093/jscr/rjx201 DB - PRIME DP - Unbound Medicine ER -