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Flavonoids in the Treatment of Alzheimer's and Other Neurodegenerative Diseases.
Curr Med Chem. 2018; 25(27):3228-3246.CM

Abstract

Flavonoids are phytochemicals present in almost all terrestrial plants and, as a consequence, in plant-based foods, and thus consumed by humans through diet. Recent evidences suggest that several flavonoids have positive effects against dementia and Alzheimer's disease, reversing age-related declines in neurocognitive performances. In this review, we provide a general classification of natural and synthetic flavonoids, a description of their physico-chemical properties, in particular their redox properties and stability, and an extensive overview about their biological activities and structure-activity relationship in the field of neurodegenerative diseases. In addition, a section will be dedicated to the synthetic strategies for the preparation of bioactive derivatives. This information will be essential for the design and development of new drugs that can improve brain functions.

Authors+Show Affiliations

Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy.Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy.Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy.Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy.Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29424298

Citation

Airoldi, Cristina, et al. "Flavonoids in the Treatment of Alzheimer's and Other Neurodegenerative Diseases." Current Medicinal Chemistry, vol. 25, no. 27, 2018, pp. 3228-3246.
Airoldi C, La Ferla B, D Orazio G, et al. Flavonoids in the Treatment of Alzheimer's and Other Neurodegenerative Diseases. Curr Med Chem. 2018;25(27):3228-3246.
Airoldi, C., La Ferla, B., D Orazio, G., Ciaramelli, C., & Palmioli, A. (2018). Flavonoids in the Treatment of Alzheimer's and Other Neurodegenerative Diseases. Current Medicinal Chemistry, 25(27), 3228-3246. https://doi.org/10.2174/0929867325666180209132125
Airoldi C, et al. Flavonoids in the Treatment of Alzheimer's and Other Neurodegenerative Diseases. Curr Med Chem. 2018;25(27):3228-3246. PubMed PMID: 29424298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonoids in the Treatment of Alzheimer's and Other Neurodegenerative Diseases. AU - Airoldi,Cristina, AU - La Ferla,Barbara, AU - D Orazio,Giuseppe, AU - Ciaramelli,Carlotta, AU - Palmioli,Alessandro, PY - 2017/04/20/received PY - 2017/09/15/revised PY - 2018/01/31/accepted PY - 2018/2/10/pubmed PY - 2018/9/14/medline PY - 2018/2/10/entrez KW - Alzheimer`s disease KW - analogues KW - antioxidants KW - flavonoids KW - neurodegenerative diseases KW - synthetic approaches. SP - 3228 EP - 3246 JF - Current medicinal chemistry JO - Curr Med Chem VL - 25 IS - 27 N2 - Flavonoids are phytochemicals present in almost all terrestrial plants and, as a consequence, in plant-based foods, and thus consumed by humans through diet. Recent evidences suggest that several flavonoids have positive effects against dementia and Alzheimer's disease, reversing age-related declines in neurocognitive performances. In this review, we provide a general classification of natural and synthetic flavonoids, a description of their physico-chemical properties, in particular their redox properties and stability, and an extensive overview about their biological activities and structure-activity relationship in the field of neurodegenerative diseases. In addition, a section will be dedicated to the synthetic strategies for the preparation of bioactive derivatives. This information will be essential for the design and development of new drugs that can improve brain functions. SN - 1875-533X UR - https://www.unboundmedicine.com/medline/citation/29424298/Flavonoids_in_the_Treatment_of_Alzheimer's_and_Other_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -