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Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease.
J Trace Elem Med Biol. 2018 Dec; 50:441-460.JT

Abstract

BACKGROUND

Kashin-Beck disease (KBD) is a childhood-onset endemic osteoarthropathy in China. Nutrients including trace elements may play active roles in the development of KBD.

OBJECTIVE

This study aimed to estimate the nutrient intakes of children in endemic areas and to identify the imbalanced nutrients associated differentially expressed genes in the juvenile patients with KBD.

METHODS

In this cross-sectional study, a consecutive 3 day 24 h semi-quantitative dietary retrospect questionnaire was conducted to estimate the daily nutrient intakes of children using CDGSS 3.0 software. Gene profile analysis was employed to identify differentially expressed genes in peripheral blood mononuclear cells of children with KBD. GOC, CTD, KEGG, and REACTOME databases were used to establish the relationship between nutrients and nutrients-associated differentially expressed genes and pathways. Statistical analyses were accomplished by SPSS 18.0 software.

RESULTS

Daily Se intakes without supplementation of children were significantly lower in Se-supplemented (Se +) KBD areas (29.3 ∼ 29.6 mg/d) and non-endemic area (27.8 ± 7.9 mg/d) compared to non-Se-supplemented (Se-) KBD area (32.9 ± 7.9 mg/d, c2 = 20.24, P < .01). Children in Se+ KBD areas were suffering more serious insufficient intake of multiple nutrients, including vitamins-B2/-C/-E, Ca, Fe, Zn and I. Gene profile analysis combined with bioinformatics technique identified 34 nutrients associated differentially expressed genes and 10 significant pathways which are related to the pathological changes in juvenile KBD.

CONCLUSIONS

Imbalance of dietary nutrients and nutrients-associated differentially expressed genes and pathways may play important roles in the development of juvenile KBD.

Authors+Show Affiliations

School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, Shaanxi 710061, PR China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, Shaanxi 710061, PR China; Xi'an Jiaotong University Global Health Institute, PR China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, Shaanxi 710061, PR China.All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, Russia; Orenburg State University, Orenburg, Russia; Yaroslavl State University, Yaroslavl, Russia; RUDN University, Moscow, Russia.Department of Biotechnology and Environmental Sciences, Thapar University, Patiala, India.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, Shaanxi 710061, PR China; Shaanxi Procincial Institute for Endemic Disease Control, PR China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, Shaanxi 710061, PR China; Shaanxi Procincial Institute for Endemic Disease Control, PR China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, Shaanxi 710061, PR China; Department of Integrative Medical Biology, University of Umeå, Umeå, Sweden, Sweden.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, Shaanxi 710061, PR China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, Shaanxi 710061, PR China. Electronic address: guox@xjtu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29426639

Citation

Ning, Yujie, et al. "Imbalance of Dietary Nutrients and the Associated Differentially Expressed Genes and Pathways May Play Important Roles in Juvenile Kashin-Beck Disease." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 50, 2018, pp. 441-460.
Ning Y, Wang X, Zhang P, et al. Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease. J Trace Elem Med Biol. 2018;50:441-460.
Ning, Y., Wang, X., Zhang, P., Anatoly, S. V., Prakash, N. T., Li, C., Zhou, R., Lammi, M., Zhang, F., & Guo, X. (2018). Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 50, 441-460. https://doi.org/10.1016/j.jtemb.2018.01.012
Ning Y, et al. Imbalance of Dietary Nutrients and the Associated Differentially Expressed Genes and Pathways May Play Important Roles in Juvenile Kashin-Beck Disease. J Trace Elem Med Biol. 2018;50:441-460. PubMed PMID: 29426639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease. AU - Ning,Yujie, AU - Wang,Xi, AU - Zhang,Pan, AU - Anatoly,Skalny V, AU - Prakash,N Tejo, AU - Li,Cheng, AU - Zhou,Rong, AU - Lammi,Mikko, AU - Zhang,Feng, AU - Guo,Xiong, Y1 - 2018/02/14/ PY - 2017/11/24/received PY - 2018/01/05/revised PY - 2018/01/23/accepted PY - 2018/2/11/pubmed PY - 2019/1/3/medline PY - 2018/2/11/entrez KW - Children KW - Differentially expressed genes KW - Kashin-Beck disease KW - Nutrients KW - Selenium SP - 441 EP - 460 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 50 N2 - BACKGROUND: Kashin-Beck disease (KBD) is a childhood-onset endemic osteoarthropathy in China. Nutrients including trace elements may play active roles in the development of KBD. OBJECTIVE: This study aimed to estimate the nutrient intakes of children in endemic areas and to identify the imbalanced nutrients associated differentially expressed genes in the juvenile patients with KBD. METHODS: In this cross-sectional study, a consecutive 3 day 24 h semi-quantitative dietary retrospect questionnaire was conducted to estimate the daily nutrient intakes of children using CDGSS 3.0 software. Gene profile analysis was employed to identify differentially expressed genes in peripheral blood mononuclear cells of children with KBD. GOC, CTD, KEGG, and REACTOME databases were used to establish the relationship between nutrients and nutrients-associated differentially expressed genes and pathways. Statistical analyses were accomplished by SPSS 18.0 software. RESULTS: Daily Se intakes without supplementation of children were significantly lower in Se-supplemented (Se +) KBD areas (29.3 ∼ 29.6 mg/d) and non-endemic area (27.8 ± 7.9 mg/d) compared to non-Se-supplemented (Se-) KBD area (32.9 ± 7.9 mg/d, c2 = 20.24, P < .01). Children in Se+ KBD areas were suffering more serious insufficient intake of multiple nutrients, including vitamins-B2/-C/-E, Ca, Fe, Zn and I. Gene profile analysis combined with bioinformatics technique identified 34 nutrients associated differentially expressed genes and 10 significant pathways which are related to the pathological changes in juvenile KBD. CONCLUSIONS: Imbalance of dietary nutrients and nutrients-associated differentially expressed genes and pathways may play important roles in the development of juvenile KBD. SN - 1878-3252 UR - https://www.unboundmedicine.com/medline/citation/29426639/Imbalance_of_dietary_nutrients_and_the_associated_differentially_expressed_genes_and_pathways_may_play_important_roles_in_juvenile_Kashin_Beck_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(17)30953-7 DB - PRIME DP - Unbound Medicine ER -