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Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Sci Rep. 2018 02 09; 8(1):2779.SR

Abstract

Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous syndrome in which patients often experience severe fatigue and malaise following exertion. Immune and cardiovascular dysfunction have been postulated to play a role in the pathophysiology. We therefore, examined whether cytokine profiling or cardiovascular testing following exercise would differentiate patients with ME/CFS. Twenty-four ME/CFS patients were matched to 24 sedentary controls and underwent cardiovascular and circulating immune profiling. Cardiovascular analysis included echocardiography, cardiopulmonary exercise and endothelial function testing. Cytokine and growth factor profiles were analyzed using a 51-plex Luminex bead kit at baseline and 18 hours following exercise. Cardiac structure and exercise capacity were similar between groups. Sparse partial least square discriminant analyses of cytokine profiles 18 hours post exercise offered the most reliable discrimination between ME/CFS and controls (κ = 0.62(0.34,0.84)). The most discriminatory cytokines post exercise were CD40L, platelet activator inhibitor, interleukin 1-β, interferon-α and CXCL1. In conclusion, cytokine profiling following exercise may help differentiate patients with ME/CFS from sedentary controls.

Links

Publisher Full Text
ncbi.nlm.nih.gov
doi.org
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Authors+Show Affiliations

Moneghetti KJ
Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. keganm@stanford.edu. Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. keganm@stanford.edu. Department of Medicine, St Vincent's Hospital, University of Melbourne, Melbourne, Australia. keganm@stanford.edu.
Skhiri M
General Medical Disciplines, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Contrepois K
Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Kobayashi Y
Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Maecker H
Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Davis M
Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Snyder M
Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Haddad F
Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Montoya JG
Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA, USA. Palo Alto Medical Foundation Toxoplasma Serology Laboratory, Palo Alto, CA, USA.

MeSH

AdultCase-Control StudiesCytokinesExerciseExercise TestFatigue Syndrome, ChronicFemaleHumansMaleMiddle Aged

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29426834

Citation

Moneghetti, Kegan J., et al. "Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome." Scientific Reports, vol. 8, no. 1, 2018, p. 2779.
Moneghetti KJ, Skhiri M, Contrepois K, et al. Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Sci Rep. 2018;8(1):2779.
Moneghetti, K. J., Skhiri, M., Contrepois, K., Kobayashi, Y., Maecker, H., Davis, M., Snyder, M., Haddad, F., & Montoya, J. G. (2018). Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Scientific Reports, 8(1), 2779. https://doi.org/10.1038/s41598-018-20941-w
Moneghetti KJ, et al. Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Sci Rep. 2018 02 9;8(1):2779. PubMed PMID: 29426834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. AU - Moneghetti,Kegan J, AU - Skhiri,Mehdi, AU - Contrepois,Kévin, AU - Kobayashi,Yukari, AU - Maecker,Holden, AU - Davis,Mark, AU - Snyder,Michael, AU - Haddad,Francois, AU - Montoya,Jose G, Y1 - 2018/02/09/ PY - 2017/11/02/received PY - 2018/01/26/accepted PY - 2018/2/11/entrez PY - 2018/2/11/pubmed PY - 2019/9/21/medline SP - 2779 EP - 2779 JF - Scientific reports JO - Sci Rep VL - 8 IS - 1 N2 - Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous syndrome in which patients often experience severe fatigue and malaise following exertion. Immune and cardiovascular dysfunction have been postulated to play a role in the pathophysiology. We therefore, examined whether cytokine profiling or cardiovascular testing following exercise would differentiate patients with ME/CFS. Twenty-four ME/CFS patients were matched to 24 sedentary controls and underwent cardiovascular and circulating immune profiling. Cardiovascular analysis included echocardiography, cardiopulmonary exercise and endothelial function testing. Cytokine and growth factor profiles were analyzed using a 51-plex Luminex bead kit at baseline and 18 hours following exercise. Cardiac structure and exercise capacity were similar between groups. Sparse partial least square discriminant analyses of cytokine profiles 18 hours post exercise offered the most reliable discrimination between ME/CFS and controls (κ = 0.62(0.34,0.84)). The most discriminatory cytokines post exercise were CD40L, platelet activator inhibitor, interleukin 1-β, interferon-α and CXCL1. In conclusion, cytokine profiling following exercise may help differentiate patients with ME/CFS from sedentary controls. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/29426834/Value_of_Circulating_Cytokine_Profiling_During_Submaximal_Exercise_Testing_in_Myalgic_Encephalomyelitis/Chronic_Fatigue_Syndrome_ L2 - https://doi.org/10.1038/s41598-018-20941-w DB - PRIME DP - Unbound Medicine ER -
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