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Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging.
Curr Biol 2018; 28(4):549-559.e3CB

Abstract

The length of myelin sheaths affects conduction speed along axons and information propagation. It has recently become clear that myelin may be adaptively modified to modulate circuit function, implying that length remodeling of myelin sheaths should occur. However, direct evidence for such events is lacking. We have investigated how myelination patterns are formed, maintained, and remodeled using long-term imaging and myelin ablation in zebrafish. We demonstrate that length differences between myelin sheaths are established by rapid and variable growth within 3 days after their formation, independently of their time of formation, and even along discontinuously myelinated axons. Afterward, sheaths continue extending at similar rates to compensate for overall animal growth. In consequence, once axon myelination patterns are established, they are maintained over long periods of time. We tested whether mature myelin sheaths can remodel by removing individual sheaths from single axons by targeted ablation. Remarkably, extensive changes in sheath length and number occurred, which frequently restored the original myelination pattern. Our results show that axons can control myelin growth and remodeling, and we provide evidence for a homeostatic control of axon myelination patterns by maintenance and remodeling of myelin sheath length, with implications for circuit development, function, and repair.

Authors+Show Affiliations

Institute of Neuronal Cell Biology, Technical University of Munich, Biedersteiner Strasse 29, 80802 Munich, Germany; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilian University of Munich, Groβhaderner Strasse 2, 82152 Planegg-Martinsried, Germany.Institute of Neuronal Cell Biology, Technical University of Munich, Biedersteiner Strasse 29, 80802 Munich, Germany.Institute of Neuronal Cell Biology, Technical University of Munich, Biedersteiner Strasse 29, 80802 Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen Strasse 17, 81377 Munich, Germany; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilian University of Munich, Groβhaderner Strasse 2, 82152 Planegg-Martinsried, Germany. Electronic address: tim.czopka@tum.de.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29429620

Citation

Auer, Franziska, et al. "Evidence for Myelin Sheath Remodeling in the CNS Revealed By in Vivo Imaging." Current Biology : CB, vol. 28, no. 4, 2018, pp. 549-559.e3.
Auer F, Vagionitis S, Czopka T. Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging. Curr Biol. 2018;28(4):549-559.e3.
Auer, F., Vagionitis, S., & Czopka, T. (2018). Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging. Current Biology : CB, 28(4), pp. 549-559.e3. doi:10.1016/j.cub.2018.01.017.
Auer F, Vagionitis S, Czopka T. Evidence for Myelin Sheath Remodeling in the CNS Revealed By in Vivo Imaging. Curr Biol. 2018 02 19;28(4):549-559.e3. PubMed PMID: 29429620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging. AU - Auer,Franziska, AU - Vagionitis,Stavros, AU - Czopka,Tim, Y1 - 2018/02/08/ PY - 2017/12/01/received PY - 2018/01/04/revised PY - 2018/01/08/accepted PY - 2018/2/13/pubmed PY - 2019/6/15/medline PY - 2018/2/13/entrez KW - central nervous system KW - in vivo imaging KW - live cell imaging KW - myelin KW - oligodendrocyte KW - zebrafish SP - 549 EP - 559.e3 JF - Current biology : CB JO - Curr. Biol. VL - 28 IS - 4 N2 - The length of myelin sheaths affects conduction speed along axons and information propagation. It has recently become clear that myelin may be adaptively modified to modulate circuit function, implying that length remodeling of myelin sheaths should occur. However, direct evidence for such events is lacking. We have investigated how myelination patterns are formed, maintained, and remodeled using long-term imaging and myelin ablation in zebrafish. We demonstrate that length differences between myelin sheaths are established by rapid and variable growth within 3 days after their formation, independently of their time of formation, and even along discontinuously myelinated axons. Afterward, sheaths continue extending at similar rates to compensate for overall animal growth. In consequence, once axon myelination patterns are established, they are maintained over long periods of time. We tested whether mature myelin sheaths can remodel by removing individual sheaths from single axons by targeted ablation. Remarkably, extensive changes in sheath length and number occurred, which frequently restored the original myelination pattern. Our results show that axons can control myelin growth and remodeling, and we provide evidence for a homeostatic control of axon myelination patterns by maintenance and remodeling of myelin sheath length, with implications for circuit development, function, and repair. SN - 1879-0445 UR - https://www.unboundmedicine.com/medline/citation/29429620/Evidence_for_Myelin_Sheath_Remodeling_in_the_CNS_Revealed_by_In_Vivo_Imaging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-9822(18)30019-8 DB - PRIME DP - Unbound Medicine ER -