Tags

Type your tag names separated by a space and hit enter

In vitro evaluation of new 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline derivatives as antimicrobial agents.
Microb Pathog. 2018 Apr; 117:60-67.MP

Abstract

Previously, seventeen 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline derivatives were prepared and characterized by physicochemical and spectral means. This study was conducted to evaluate their activities in vitro against five Gram-negative and five Gram-positive of clinically pathogenic bacterial strains and ten fungal strains. The antimicrobial activity was assessed, and the minimum inhibitory concentration values of the tested compounds were determined in μg ml-1, using the diffusion agar technique. The bacterial strains used were Escherichia coli (ATCC 25922), Proteus mirabilis (ATCC 7002), Klebsiella oxytoca (ATCC 700324), Pseudomonas aeruginosa (ATCC 10145), Enterobacter cloacae (ATCC 13047D-5), Bacillus subtilis (NRRL B-543), Enterococcus faecalis (RCMB 0100154-2), Staphylococcus aureus (ATCC 29213), Staphylococcus epidermidis (ATCC 12228), and Streptococcus pyogenes (RCMB 0100174-2). Aspergillus fumigatus (RCMB 02568), Syncephalastrum racemosum (IMI 21178), Geotricum candidum (IMI 329542), Candida albicans (ATCC 10231), Aspergillus niger (IMI 130783), Cryptococcus neoformans (NRRL Y-1518), Candida tropicalis (RCMB 05239), Penicillium expansum (IMI 146655), Microsporum canis (RCMB 0834), and Trichophyton mentagrophytes (RCMB 0925) were used as the fungal strains. Ampicillin and gentamicin were used as reference antibacterial drugs and amphotericin B was used as the reference antifungal drug. The antimicrobial studies revealed that the tested compounds 6-8, 11, 12, and 14-16 showed the highest activities against the bacterial and fungal strains. The current study showed that some benzo[g]traizoloquinazolines displayed remarkable antimicrobial activity and could be used as template for further design of potent antimicrobial agent.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2452, Riyadh 11495, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt.Department of Chemistry, College of Science and Humanities, Prince Sattam bin Abdulaziz University, 83 Alkharj, Saudi Arabia; Chemistry of Natural Products Group, Center of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo 12622, Egypt.Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. Electronic address: ralsalahi@ksu.edu.sa.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29432912

Citation

Abuelizz, Hatem A., et al. "In Vitro Evaluation of New 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline Derivatives as Antimicrobial Agents." Microbial Pathogenesis, vol. 117, 2018, pp. 60-67.
Abuelizz HA, El-Dib RA, Marzouk M, et al. In vitro evaluation of new 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline derivatives as antimicrobial agents. Microb Pathog. 2018;117:60-67.
Abuelizz, H. A., El-Dib, R. A., Marzouk, M., & Al-Salahi, R. (2018). In vitro evaluation of new 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline derivatives as antimicrobial agents. Microbial Pathogenesis, 117, 60-67. https://doi.org/10.1016/j.micpath.2018.02.018
Abuelizz HA, et al. In Vitro Evaluation of New 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline Derivatives as Antimicrobial Agents. Microb Pathog. 2018;117:60-67. PubMed PMID: 29432912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro evaluation of new 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline derivatives as antimicrobial agents. AU - Abuelizz,Hatem A, AU - El-Dib,Rabab A, AU - Marzouk,Mohamed, AU - Al-Salahi,Rashad, Y1 - 2018/02/09/ PY - 2018/01/02/received PY - 2018/01/30/revised PY - 2018/02/08/accepted PY - 2018/2/13/pubmed PY - 2018/9/5/medline PY - 2018/2/13/entrez KW - Antibacterial activity KW - Antifungal activity KW - Benzotriazoloquinazoline KW - Minimum inhibitory concentration SP - 60 EP - 67 JF - Microbial pathogenesis JO - Microb. Pathog. VL - 117 N2 - Previously, seventeen 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline derivatives were prepared and characterized by physicochemical and spectral means. This study was conducted to evaluate their activities in vitro against five Gram-negative and five Gram-positive of clinically pathogenic bacterial strains and ten fungal strains. The antimicrobial activity was assessed, and the minimum inhibitory concentration values of the tested compounds were determined in μg ml-1, using the diffusion agar technique. The bacterial strains used were Escherichia coli (ATCC 25922), Proteus mirabilis (ATCC 7002), Klebsiella oxytoca (ATCC 700324), Pseudomonas aeruginosa (ATCC 10145), Enterobacter cloacae (ATCC 13047D-5), Bacillus subtilis (NRRL B-543), Enterococcus faecalis (RCMB 0100154-2), Staphylococcus aureus (ATCC 29213), Staphylococcus epidermidis (ATCC 12228), and Streptococcus pyogenes (RCMB 0100174-2). Aspergillus fumigatus (RCMB 02568), Syncephalastrum racemosum (IMI 21178), Geotricum candidum (IMI 329542), Candida albicans (ATCC 10231), Aspergillus niger (IMI 130783), Cryptococcus neoformans (NRRL Y-1518), Candida tropicalis (RCMB 05239), Penicillium expansum (IMI 146655), Microsporum canis (RCMB 0834), and Trichophyton mentagrophytes (RCMB 0925) were used as the fungal strains. Ampicillin and gentamicin were used as reference antibacterial drugs and amphotericin B was used as the reference antifungal drug. The antimicrobial studies revealed that the tested compounds 6-8, 11, 12, and 14-16 showed the highest activities against the bacterial and fungal strains. The current study showed that some benzo[g]traizoloquinazolines displayed remarkable antimicrobial activity and could be used as template for further design of potent antimicrobial agent. SN - 1096-1208 UR - https://www.unboundmedicine.com/medline/citation/29432912/In_vitro_evaluation_of_new_2_phenoxy_benzo[g][124]triazolo[15_a]quinazoline_derivatives_as_antimicrobial_agents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0882-4010(18)30009-3 DB - PRIME DP - Unbound Medicine ER -