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The Protective Effects of Gardenia jasminoides (Fructus Gardenia) on Amyloid-β-Induced Mouse Cognitive Impairment and Neurotoxicity.
Am J Chin Med 2018; 46(2):389-405AJ

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. Although the exact causes of AD have not yet been fully elucidated, cholinergic dysfunction, mitochondrial damage, oxidative stress and neuroinflammation have been recognized as influential factors. Current drugs that are designed to address only a single target are unable to mitigate or prevent the progression of this complicated disease, so new disease-modifying drugs are urgently needed. Chinese herbs with thousand years of effective usage might be a good source for potential drugs. Gardenia jasminoides J. Ellis (Fructus Gardenia) is a common traditional Chinese medicine with tranquilizing effects, which is an important component of widely-used traditional Chinese medicine for dementia. GJ-4 is crocin richments extracted from Gardenia jasminoides J. Ellis. In our study, we attempted to observe the effects of GJ-4 on learning and memory injury induced by amyloid-[Formula: see text] 25-35 (A[Formula: see text] injection in mice. Treatment with GJ-4 dose-dependently enhanced the memory and cognition ability of A[Formula: see text]-injected mice. Preliminary mechanistic studies revealed the protective effect of GJ-4 was related to its protection of neurons and cholinergic dysfunction. The mechanistic results also indicated that GJ-4 could enhance antioxidant capacity and attenuate neuroinflammation. Our results implied that GJ-4 might be a promising drug to improve cognitive and memory impairment, with multiple targets.

Authors+Show Affiliations

* Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, P. R. China.* Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, P. R. China.† Institute of TCM & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China.* Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, P. R. China.* Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, P. R. China.* Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, P. R. China.* Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, P. R. China.† Institute of TCM & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China.* Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, P. R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29433392

Citation

Zang, Cai-Xia, et al. "The Protective Effects of Gardenia Jasminoides (Fructus Gardenia) On Amyloid-β-Induced Mouse Cognitive Impairment and Neurotoxicity." The American Journal of Chinese Medicine, vol. 46, no. 2, 2018, pp. 389-405.
Zang CX, Bao XQ, Li L, et al. The Protective Effects of Gardenia jasminoides (Fructus Gardenia) on Amyloid-β-Induced Mouse Cognitive Impairment and Neurotoxicity. Am J Chin Med. 2018;46(2):389-405.
Zang, C. X., Bao, X. Q., Li, L., Yang, H. Y., Wang, L., Yu, Y., ... Zhang, D. (2018). The Protective Effects of Gardenia jasminoides (Fructus Gardenia) on Amyloid-β-Induced Mouse Cognitive Impairment and Neurotoxicity. The American Journal of Chinese Medicine, 46(2), pp. 389-405. doi:10.1142/S0192415X18500192.
Zang CX, et al. The Protective Effects of Gardenia Jasminoides (Fructus Gardenia) On Amyloid-β-Induced Mouse Cognitive Impairment and Neurotoxicity. Am J Chin Med. 2018;46(2):389-405. PubMed PMID: 29433392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Protective Effects of Gardenia jasminoides (Fructus Gardenia) on Amyloid-β-Induced Mouse Cognitive Impairment and Neurotoxicity. AU - Zang,Cai-Xia, AU - Bao,Xiu-Qi, AU - Li,Lin, AU - Yang,Han-Yu, AU - Wang,Lu, AU - Yu,Yang, AU - Wang,Xiao-Liang, AU - Yao,Xin-Sheng, AU - Zhang,Dan, Y1 - 2018/02/12/ PY - 2018/2/13/pubmed PY - 2018/8/4/medline PY - 2018/2/14/entrez KW - Alzheimer’s Disease KW - Amyloid Protein KW - GJ-4 KW - Gardenia Jasminoides J. Ellis KW - Learning and Memory KW - Neuroprotection SP - 389 EP - 405 JF - The American journal of Chinese medicine JO - Am. J. Chin. Med. VL - 46 IS - 2 N2 - Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. Although the exact causes of AD have not yet been fully elucidated, cholinergic dysfunction, mitochondrial damage, oxidative stress and neuroinflammation have been recognized as influential factors. Current drugs that are designed to address only a single target are unable to mitigate or prevent the progression of this complicated disease, so new disease-modifying drugs are urgently needed. Chinese herbs with thousand years of effective usage might be a good source for potential drugs. Gardenia jasminoides J. Ellis (Fructus Gardenia) is a common traditional Chinese medicine with tranquilizing effects, which is an important component of widely-used traditional Chinese medicine for dementia. GJ-4 is crocin richments extracted from Gardenia jasminoides J. Ellis. In our study, we attempted to observe the effects of GJ-4 on learning and memory injury induced by amyloid-[Formula: see text] 25-35 (A[Formula: see text] injection in mice. Treatment with GJ-4 dose-dependently enhanced the memory and cognition ability of A[Formula: see text]-injected mice. Preliminary mechanistic studies revealed the protective effect of GJ-4 was related to its protection of neurons and cholinergic dysfunction. The mechanistic results also indicated that GJ-4 could enhance antioxidant capacity and attenuate neuroinflammation. Our results implied that GJ-4 might be a promising drug to improve cognitive and memory impairment, with multiple targets. SN - 1793-6853 UR - https://www.unboundmedicine.com/medline/citation/29433392/The_Protective_Effects_of_Gardenia_jasminoides__Fructus_Gardenia__on_Amyloid_β_Induced_Mouse_Cognitive_Impairment_and_Neurotoxicity_ L2 - https://www.worldscientific.com/doi/full/10.1142/S0192415X18500192?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -