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Type 2 choroidal neovascularisation in polypoidal choroidal vasculopathy: a retrospective case series.
Br J Ophthalmol. 2018 11; 102(11):1570-1574.BJ

Abstract

BACKGROUND AND OBJECTIVE

To demonstrate the coexistence of polypoidal choroidal vasculopathy (PCV) with type 2 neovascularisation (NV), we used multimodal imaging, including spectral-domain optical coherence tomography angiography (SD-OCTA), to identify both types of lesions in the same eye.

STUDY DESIGN

This retrospective case series reviewed patients with PCV diagnosed with indocyanine green angiography (ICGA), fluorescein angiography (FA), SD-OCT and SD-OCTA.

RESULTS

15 eyes of 14 patients were imaged and diagnosed with PCV by ICGA. ICGA identified polyps in all these eyes, while SD-OCTA imaging identified polypoidal lesions in only 11 (73%) of these eyes with PCV. Branching vascular networks (BVNs) were detected in 12 eyes (80%) by ICGA and SD-OCTA. Type 2 NV was detected in four eyes (27%) by FA and SD-OCTA. In these eyes, a combination of polyps, BVNs and type 2 NV were detected using FA, ICGA and SD-OCTA.

CONCLUSION

BVN and type 2 NV can coexist in the same PCV eye and communicate with each other. This suggests that polyps may represent a structural variant of neovascular tissue rather than a distinct pathogenic process in NV.

Authors+Show Affiliations

Department of Ophthalmology, Peking University People's Hospital, Beijing, China. Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. Collage of Optometry, Peking University health Science Center, Beijing, China.Department of Ophthalmology, Peking University People's Hospital, Beijing, China. Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. Collage of Optometry, Peking University health Science Center, Beijing, China.Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.Department of Ophthalmology, Peking University People's Hospital, Beijing, China. Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China.

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29436399

Citation

Liang, Shuting, et al. "Type 2 Choroidal Neovascularisation in Polypoidal Choroidal Vasculopathy: a Retrospective Case Series." The British Journal of Ophthalmology, vol. 102, no. 11, 2018, pp. 1570-1574.
Liang S, Shi X, Rosenfeld PJ, et al. Type 2 choroidal neovascularisation in polypoidal choroidal vasculopathy: a retrospective case series. Br J Ophthalmol. 2018;102(11):1570-1574.
Liang, S., Shi, X., Rosenfeld, P. J., & Li, X. (2018). Type 2 choroidal neovascularisation in polypoidal choroidal vasculopathy: a retrospective case series. The British Journal of Ophthalmology, 102(11), 1570-1574. https://doi.org/10.1136/bjophthalmol-2017-311518
Liang S, et al. Type 2 Choroidal Neovascularisation in Polypoidal Choroidal Vasculopathy: a Retrospective Case Series. Br J Ophthalmol. 2018;102(11):1570-1574. PubMed PMID: 29436399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Type 2 choroidal neovascularisation in polypoidal choroidal vasculopathy: a retrospective case series. AU - Liang,Shuting, AU - Shi,Xuan, AU - Rosenfeld,Philip J, AU - Li,Xiaoxin, Y1 - 2018/02/07/ PY - 2017/10/26/received PY - 2018/01/04/revised PY - 2018/01/14/accepted PY - 2018/2/14/pubmed PY - 2019/6/1/medline PY - 2018/2/14/entrez KW - Optical Coherence Tomography Angiography (OCTA) KW - Polypoidal Choroidal Vasculopathy (PCV) KW - neovascular Age-related Macular Degeneration (nAMD) SP - 1570 EP - 1574 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 102 IS - 11 N2 - BACKGROUND AND OBJECTIVE: To demonstrate the coexistence of polypoidal choroidal vasculopathy (PCV) with type 2 neovascularisation (NV), we used multimodal imaging, including spectral-domain optical coherence tomography angiography (SD-OCTA), to identify both types of lesions in the same eye. STUDY DESIGN: This retrospective case series reviewed patients with PCV diagnosed with indocyanine green angiography (ICGA), fluorescein angiography (FA), SD-OCT and SD-OCTA. RESULTS: 15 eyes of 14 patients were imaged and diagnosed with PCV by ICGA. ICGA identified polyps in all these eyes, while SD-OCTA imaging identified polypoidal lesions in only 11 (73%) of these eyes with PCV. Branching vascular networks (BVNs) were detected in 12 eyes (80%) by ICGA and SD-OCTA. Type 2 NV was detected in four eyes (27%) by FA and SD-OCTA. In these eyes, a combination of polyps, BVNs and type 2 NV were detected using FA, ICGA and SD-OCTA. CONCLUSION: BVN and type 2 NV can coexist in the same PCV eye and communicate with each other. This suggests that polyps may represent a structural variant of neovascular tissue rather than a distinct pathogenic process in NV. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/29436399/Type_2_choroidal_neovascularisation_in_polypoidal_choroidal_vasculopathy:_a_retrospective_case_series_ L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&pmid=29436399 DB - PRIME DP - Unbound Medicine ER -