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Actin, microtubule, septin and ESCRT filament remodeling during late steps of cytokinesis.
Curr Opin Cell Biol. 2018 02; 50:27-34.CO

Abstract

Cytokinesis is the process by which a mother cell is physically cleaved into two daughter cells. In animal cells, cytokinesis begins with the contraction of a plasma membrane-associated actomyosin ring that is responsible for the ingression of a cleavage furrow. However, the post-furrowing steps of cytokinesis are less understood. Here, we highlight key recent findings that reveal a profound remodeling of several classes of cytoskeletal elements and cytoplasmic filaments (septins, microtubules, actin and ESCRT) in the late steps of cytokinesis. We review how this remodeling is required first for the stabilization of the intercellular bridge connecting the daughter cells and then for the steps leading up to abscission. New players regulating the abscission (NoCut) checkpoint, which delays abscission via cytoskeleton and ESCRT remodeling in response to various cytokinetic stresses, will also be emphasized. Altogether, the latest discoveries reveal a crucial role for posttranslational modifications of the cytoskeleton (actin oxidation, septin SUMOylation) and an unexpected requirement of ESCRT-III polymer dynamics for successful abscission.

Authors+Show Affiliations

Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris cedex 15, France; Centre National de la Recherche Scientifique CNRS UMR3691, 75015 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie, Université Paris 06, Institut de formation doctorale, 75252 Paris, France.Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris cedex 15, France; Centre National de la Recherche Scientifique CNRS UMR3691, 75015 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie, Université Paris 06, Institut de formation doctorale, 75252 Paris, France.Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris cedex 15, France; Centre National de la Recherche Scientifique CNRS UMR3691, 75015 Paris, France. Electronic address: arnaud.echard@pasteur.fr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29438904

Citation

Addi, Cyril, et al. "Actin, Microtubule, Septin and ESCRT Filament Remodeling During Late Steps of Cytokinesis." Current Opinion in Cell Biology, vol. 50, 2018, pp. 27-34.
Addi C, Bai J, Echard A. Actin, microtubule, septin and ESCRT filament remodeling during late steps of cytokinesis. Curr Opin Cell Biol. 2018;50:27-34.
Addi, C., Bai, J., & Echard, A. (2018). Actin, microtubule, septin and ESCRT filament remodeling during late steps of cytokinesis. Current Opinion in Cell Biology, 50, 27-34. https://doi.org/10.1016/j.ceb.2018.01.007
Addi C, Bai J, Echard A. Actin, Microtubule, Septin and ESCRT Filament Remodeling During Late Steps of Cytokinesis. Curr Opin Cell Biol. 2018;50:27-34. PubMed PMID: 29438904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Actin, microtubule, septin and ESCRT filament remodeling during late steps of cytokinesis. AU - Addi,Cyril, AU - Bai,Jian, AU - Echard,Arnaud, Y1 - 2018/02/10/ PY - 2017/12/13/received PY - 2018/01/18/revised PY - 2018/01/23/accepted PY - 2018/2/14/pubmed PY - 2019/1/15/medline PY - 2018/2/14/entrez SP - 27 EP - 34 JF - Current opinion in cell biology JO - Curr Opin Cell Biol VL - 50 N2 - Cytokinesis is the process by which a mother cell is physically cleaved into two daughter cells. In animal cells, cytokinesis begins with the contraction of a plasma membrane-associated actomyosin ring that is responsible for the ingression of a cleavage furrow. However, the post-furrowing steps of cytokinesis are less understood. Here, we highlight key recent findings that reveal a profound remodeling of several classes of cytoskeletal elements and cytoplasmic filaments (septins, microtubules, actin and ESCRT) in the late steps of cytokinesis. We review how this remodeling is required first for the stabilization of the intercellular bridge connecting the daughter cells and then for the steps leading up to abscission. New players regulating the abscission (NoCut) checkpoint, which delays abscission via cytoskeleton and ESCRT remodeling in response to various cytokinetic stresses, will also be emphasized. Altogether, the latest discoveries reveal a crucial role for posttranslational modifications of the cytoskeleton (actin oxidation, septin SUMOylation) and an unexpected requirement of ESCRT-III polymer dynamics for successful abscission. SN - 1879-0410 UR - https://www.unboundmedicine.com/medline/citation/29438904/Actin_microtubule_septin_and_ESCRT_filament_remodeling_during_late_steps_of_cytokinesis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-0674(17)30130-8 DB - PRIME DP - Unbound Medicine ER -