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Cytotoxic and Antimicrobial Compounds from the Marine-Derived Fungus, Penicillium Species.
Molecules. 2018 Feb 12; 23(2)M

Abstract

The organic extract of liquid cultures of the marine-derived Penicillium sp. was investigated. Fractionation of the extracts of the fungus led to the purification and identification of two new compounds, penicillatides A (1) and B (2), together with the previously reported cyclo(R-Pro-S-Phe) (3) and cyclo(R-Pro-R-Phe) (4). The structures of compounds 1-4 were assigned by extensive interpretation of their NMR and high-resolution mass spectrometry (HRMS). The antiproliferative and cytotoxic activities of the compounds against three human cancer cell lines as well as their antimicrobial activity against several pathogens were evaluated. Compounds 2-4 displayed variable cytotoxic and antimicrobial activities.

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Authors+Show Affiliations

Youssef DTA
Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. dyoussef@kau.edu.sa.
Alahdal AM
Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. aalahdal2@hotmail.com.

MeSH

Anti-Bacterial AgentsAntifungal AgentsAntineoplastic AgentsAquatic OrganismsCandida albicansDiketopiperazinesDisk Diffusion Antimicrobial TestsHCT116 CellsHep G2 CellsHumansInhibitory Concentration 50MCF-7 CellsMagnetic Resonance SpectroscopyModels, ChemicalPenicilliumStaphylococcus aureusStructure-Activity RelationshipVibrio

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29439550

Citation

Youssef, Diaa T A., and Abdulrahman M. Alahdal. "Cytotoxic and Antimicrobial Compounds From the Marine-Derived Fungus, Penicillium Species." Molecules (Basel, Switzerland), vol. 23, no. 2, 2018.
Youssef DTA, Alahdal AM. Cytotoxic and Antimicrobial Compounds from the Marine-Derived Fungus, Penicillium Species. Molecules. 2018;23(2).
Youssef, D. T. A., & Alahdal, A. M. (2018). Cytotoxic and Antimicrobial Compounds from the Marine-Derived Fungus, Penicillium Species. Molecules (Basel, Switzerland), 23(2). https://doi.org/10.3390/molecules23020394
Youssef DTA, Alahdal AM. Cytotoxic and Antimicrobial Compounds From the Marine-Derived Fungus, Penicillium Species. Molecules. 2018 Feb 12;23(2) PubMed PMID: 29439550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic and Antimicrobial Compounds from the Marine-Derived Fungus, Penicillium Species. AU - Youssef,Diaa T A, AU - Alahdal,Abdulrahman M, Y1 - 2018/02/12/ PY - 2018/01/07/received PY - 2018/02/05/revised PY - 2018/02/06/accepted PY - 2018/2/15/entrez PY - 2018/2/15/pubmed PY - 2018/8/18/medline KW - 2,5-diketopiperazines KW - cytotoxic and antimicrobial activities KW - marine Penicillium sp. JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 2 N2 - The organic extract of liquid cultures of the marine-derived Penicillium sp. was investigated. Fractionation of the extracts of the fungus led to the purification and identification of two new compounds, penicillatides A (1) and B (2), together with the previously reported cyclo(R-Pro-S-Phe) (3) and cyclo(R-Pro-R-Phe) (4). The structures of compounds 1-4 were assigned by extensive interpretation of their NMR and high-resolution mass spectrometry (HRMS). The antiproliferative and cytotoxic activities of the compounds against three human cancer cell lines as well as their antimicrobial activity against several pathogens were evaluated. Compounds 2-4 displayed variable cytotoxic and antimicrobial activities. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/29439550/Cytotoxic_and_Antimicrobial_Compounds_from_the_Marine_Derived_Fungus_Penicillium_Species_ DB - PRIME DP - Unbound Medicine ER -