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Zika virus outbreak: a review of neurological complications, diagnosis, and treatment options.
J Neurovirol. 2018 06; 24(3):255-272.JN

Abstract

Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika causes mildly symptomatic infections fever, headache, rash, arthralgia, and conjunctivitis, the recent outbreak associated ZIKV to serious neurological complications such as microcephaly, Guillain-Barré syndrome, and eye infections. The recent outbreak has resulted in an astonishing number of microcephaly cases in fetus and infants. Consequently, numerous studies were conducted using in vitro cell and in vivo animal models. These studies showed clear links between ZIKV infections and neurological abnormalities. Diagnosis methods based on nucleic acid and serological detection facilitated rapid and accurate identification of ZIKV infections. New transmission modalities such as sexual and transplacental transmission were uncovered. Given the seriousness of ZIKV infections, WHO declared the development of safe and effective vaccines and new antiviral drugs as an urgent global health priority. Rapid work in this direction has led to the identification of several vaccine and antiviral drug candidates. Here, we review the remarkable progress made in understanding the molecular links between ZIKV infections and neurological irregularities, new diagnosis methods, potential targets for antiviral drugs, and the current state of vaccine development.

Authors+Show Affiliations

Global Bioassay Development and Quality, Biopharmaceutical Development, MedImmune, Gaithersburg, MD, USA.Global Bioassay Development and Quality, Biopharmaceutical Development, MedImmune, Gaithersburg, MD, USA. tshantharaju@yahoo.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29441490

Citation

Koppolu, Veerendra, and T Shantha Raju. "Zika Virus Outbreak: a Review of Neurological Complications, Diagnosis, and Treatment Options." Journal of Neurovirology, vol. 24, no. 3, 2018, pp. 255-272.
Koppolu V, Shantha Raju T. Zika virus outbreak: a review of neurological complications, diagnosis, and treatment options. J Neurovirol. 2018;24(3):255-272.
Koppolu, V., & Shantha Raju, T. (2018). Zika virus outbreak: a review of neurological complications, diagnosis, and treatment options. Journal of Neurovirology, 24(3), 255-272. https://doi.org/10.1007/s13365-018-0614-8
Koppolu V, Shantha Raju T. Zika Virus Outbreak: a Review of Neurological Complications, Diagnosis, and Treatment Options. J Neurovirol. 2018;24(3):255-272. PubMed PMID: 29441490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zika virus outbreak: a review of neurological complications, diagnosis, and treatment options. AU - Koppolu,Veerendra, AU - Shantha Raju,T, Y1 - 2018/02/13/ PY - 2017/08/23/received PY - 2018/01/18/accepted PY - 2018/2/15/pubmed PY - 2019/11/9/medline PY - 2018/2/15/entrez KW - Aedes mosquito KW - Antiviral chemotherapy KW - Flavivirus KW - Guillain-Barre syndrome KW - Microcephaly KW - Neuropathogen KW - Zika vaccine KW - Zika virus SP - 255 EP - 272 JF - Journal of neurovirology JO - J. Neurovirol. VL - 24 IS - 3 N2 - Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika causes mildly symptomatic infections fever, headache, rash, arthralgia, and conjunctivitis, the recent outbreak associated ZIKV to serious neurological complications such as microcephaly, Guillain-Barré syndrome, and eye infections. The recent outbreak has resulted in an astonishing number of microcephaly cases in fetus and infants. Consequently, numerous studies were conducted using in vitro cell and in vivo animal models. These studies showed clear links between ZIKV infections and neurological abnormalities. Diagnosis methods based on nucleic acid and serological detection facilitated rapid and accurate identification of ZIKV infections. New transmission modalities such as sexual and transplacental transmission were uncovered. Given the seriousness of ZIKV infections, WHO declared the development of safe and effective vaccines and new antiviral drugs as an urgent global health priority. Rapid work in this direction has led to the identification of several vaccine and antiviral drug candidates. Here, we review the remarkable progress made in understanding the molecular links between ZIKV infections and neurological irregularities, new diagnosis methods, potential targets for antiviral drugs, and the current state of vaccine development. SN - 1538-2443 UR - https://www.unboundmedicine.com/medline/citation/29441490/Zika_virus_outbreak:_a_review_of_neurological_complications_diagnosis_and_treatment_options_ L2 - https://dx.doi.org/10.1007/s13365-018-0614-8 DB - PRIME DP - Unbound Medicine ER -