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Anti-platelet effects of chalcones from Angelica keiskei Koidzumi (Ashitaba) in vivo.
Pharmazie. 2016 Nov 02; 71(11):651-654.P

Abstract

Angelica keiskei Koidzumi (Ashitaba) is a traditional folk medicine that is also regarded in Japan as a health food with potential antithrombotic properties. The ability of the major chalcones, xanthoangelol (XA) and 4-hydroxyderricin (4-HD) extracted from Ashitaba roots to inhibit platelet aggregation activity in vitro was recently determined. However, the anti-platelet activities of Ashitaba chalcones in vivo have remained unclear. The present study examines the anti-platelet effects of Ashitaba exudate and its constituent chalcones using mouse tail-bleeding models that reflect platelet aggregation in vivo. Ashitaba exudate and the major chalcone subtype XA, suppressed the lipopolysaccharide (LPS)-induced shortening of mouse tail bleeding. However, trace amounts of other Ashitaba chalcone subtypes including xanthoangelols B (XB), D (XD), E (XE) and F (XF) did not affect tail bleeding. These results suggest that the major chalcone subtype in Ashitaba, XA, has anti-platelet-activities in vivo.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

29441970

Citation

Ohkura, N, et al. "Anti-platelet Effects of Chalcones From Angelica Keiskei Koidzumi (Ashitaba) in Vivo." Die Pharmazie, vol. 71, no. 11, 2016, pp. 651-654.
Ohkura N, Ohnishi K, Taniguchi M, et al. Anti-platelet effects of chalcones from Angelica keiskei Koidzumi (Ashitaba) in vivo. Pharmazie. 2016;71(11):651-654.
Ohkura, N., Ohnishi, K., Taniguchi, M., Nakayama, A., Usuba, Y., Fujita, M., Fujii, A., Ishibashi, K., Baba, K., & Atsumi, G. (2016). Anti-platelet effects of chalcones from Angelica keiskei Koidzumi (Ashitaba) in vivo. Die Pharmazie, 71(11), 651-654. https://doi.org/10.1691/ph.2016.6678
Ohkura N, et al. Anti-platelet Effects of Chalcones From Angelica Keiskei Koidzumi (Ashitaba) in Vivo. Pharmazie. 2016 Nov 2;71(11):651-654. PubMed PMID: 29441970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-platelet effects of chalcones from Angelica keiskei Koidzumi (Ashitaba) in vivo. AU - Ohkura,N, AU - Ohnishi,K, AU - Taniguchi,M, AU - Nakayama,A, AU - Usuba,Y, AU - Fujita,M, AU - Fujii,A, AU - Ishibashi,K, AU - Baba,K, AU - Atsumi,G, PY - 2018/2/15/entrez PY - 2016/11/2/pubmed PY - 2018/3/9/medline SP - 651 EP - 654 JF - Die Pharmazie JO - Pharmazie VL - 71 IS - 11 N2 - Angelica keiskei Koidzumi (Ashitaba) is a traditional folk medicine that is also regarded in Japan as a health food with potential antithrombotic properties. The ability of the major chalcones, xanthoangelol (XA) and 4-hydroxyderricin (4-HD) extracted from Ashitaba roots to inhibit platelet aggregation activity in vitro was recently determined. However, the anti-platelet activities of Ashitaba chalcones in vivo have remained unclear. The present study examines the anti-platelet effects of Ashitaba exudate and its constituent chalcones using mouse tail-bleeding models that reflect platelet aggregation in vivo. Ashitaba exudate and the major chalcone subtype XA, suppressed the lipopolysaccharide (LPS)-induced shortening of mouse tail bleeding. However, trace amounts of other Ashitaba chalcone subtypes including xanthoangelols B (XB), D (XD), E (XE) and F (XF) did not affect tail bleeding. These results suggest that the major chalcone subtype in Ashitaba, XA, has anti-platelet-activities in vivo. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/29441970/Anti_platelet_effects_of_chalcones_from_Angelica_keiskei_Koidzumi__Ashitaba__in_vivo_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=0031-7144&volume=71&issue=11&spage=651&aulast=Ohkura DB - PRIME DP - Unbound Medicine ER -