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The possible link between coeliac and Kawasaki diseases in Brazil: a cross-sectional study.
BMJ Open. 2018 02 14; 8(2):e018803.BO

Abstract

BACKGROUND

Kawasaki disease (KD) is a self-limited acute systemic vasculitis of unknown aetiology that predominantly affects infants and young children eventually associated with immunological abnormalities. Coeliac disease (CD) is an inflammatory autoimmune disease characterised by a permanent gluten intolerance, which affects genetically susceptible individuals of any age group, and can cause intestinal and systemic symptoms. Association of CD with KD has been previously described in a single study that disclosed a surprisingly high prevalence of CD in children with a history of KD.

OBJECTIVE

To confirm the existence of a higher prevalence of CD among individuals with a history of KD, which would turn the screening for CD in patients with history of KD highly advisable.

SETTING

Children with history of KD, diagnosed and followed at the Rheumatology Clinic of the Children's Hospital of Brasilia (Brasilia, Brazil).

PARTICIPANTS

This study included 110 children with history of KD and a control group composed of 110 presumably healthy children.

INTERVENTIONS

Participants underwent anti-transglutaminase and anti-endomysial antibodies tests and genetic typing for the presence of CD predisposing alleles (HLA-DQ2 and DQ8). Jejunal biopsy was performed when necessary, according the European Society of Paediatric Gastroenterology, Hepatology and Nutrition guidelines.

RESULTS

Diagnosis of CD was confirmed in one (0.91%) patient with KD by positive serological tests, presence of predisposing alleles and CD typical lesions on duodenal biopsy. All serological tests were negative among the controls. The prevalence of CD predisposing alleles among patients with KD was 29.09%, similar to the prevalence found among controls, 33.64%.

CONCLUSION

The detected CD prevalence (0.91%) does not confirm the existence of an association between KD and CD since this prevalence is similar to that found in the general population (≃1%).

Authors+Show Affiliations

No affiliation info availableInterdisciplinary Laboratory of Biosciences and Celiac Disease Research Center, School of Medicine, University of Brasilia, Brasilia, Brazil. Post-graduate Program in Health Sciences, School of Health Sciences, University of Brasilia, Brasilia, Brazil.Interdisciplinary Laboratory of Biosciences and Celiac Disease Research Center, School of Medicine, University of Brasilia, Brasilia, Brazil. Post-graduate Program in Health Sciences, School of Health Sciences, University of Brasilia, Brasilia, Brazil.Pediatric Rheumatology Unit, Children's Hospital José Alencar, Brasilia, Brazil. School of Medicine, University of Brasilia - UNB, Brasilia, DF, Brazil.Interdisciplinary Laboratory of Biosciences and Celiac Disease Research Center, School of Medicine, University of Brasilia, Brasilia, Brazil. Post-graduate Program in Health Sciences, School of Health Sciences, University of Brasilia, Brasilia, Brazil.Interdisciplinary Laboratory of Biosciences and Celiac Disease Research Center, School of Medicine, University of Brasilia, Brasilia, Brazil. Post-graduate Program in Health Sciences, School of Health Sciences, University of Brasilia, Brasilia, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29444780

Citation

Dos Santos Domingues, Alessandra, et al. "The Possible Link Between Coeliac and Kawasaki Diseases in Brazil: a Cross-sectional Study." BMJ Open, vol. 8, no. 2, 2018, pp. e018803.
Dos Santos Domingues A, Selleski N, Uenishi RH, et al. The possible link between coeliac and Kawasaki diseases in Brazil: a cross-sectional study. BMJ Open. 2018;8(2):e018803.
Dos Santos Domingues, A., Selleski, N., Uenishi, R. H., Medeiros Ribeiro de Magalhães, C., Gandolfi, L., & Pratesi, C. B. (2018). The possible link between coeliac and Kawasaki diseases in Brazil: a cross-sectional study. BMJ Open, 8(2), e018803. https://doi.org/10.1136/bmjopen-2017-018803
Dos Santos Domingues A, et al. The Possible Link Between Coeliac and Kawasaki Diseases in Brazil: a Cross-sectional Study. BMJ Open. 2018 02 14;8(2):e018803. PubMed PMID: 29444780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The possible link between coeliac and Kawasaki diseases in Brazil: a cross-sectional study. AU - Dos Santos Domingues,Alessandra, AU - Selleski,Nicole, AU - Uenishi,Rosa Harumi, AU - Medeiros Ribeiro de Magalhães,Cristina, AU - Gandolfi,Lenora, AU - Pratesi,Claudia B, Y1 - 2018/02/14/ PY - 2018/2/16/entrez PY - 2018/2/16/pubmed PY - 2018/8/31/medline KW - Kawasaki disease KW - celiac disease KW - prevalence SP - e018803 EP - e018803 JF - BMJ open JO - BMJ Open VL - 8 IS - 2 N2 - BACKGROUND: Kawasaki disease (KD) is a self-limited acute systemic vasculitis of unknown aetiology that predominantly affects infants and young children eventually associated with immunological abnormalities. Coeliac disease (CD) is an inflammatory autoimmune disease characterised by a permanent gluten intolerance, which affects genetically susceptible individuals of any age group, and can cause intestinal and systemic symptoms. Association of CD with KD has been previously described in a single study that disclosed a surprisingly high prevalence of CD in children with a history of KD. OBJECTIVE: To confirm the existence of a higher prevalence of CD among individuals with a history of KD, which would turn the screening for CD in patients with history of KD highly advisable. SETTING: Children with history of KD, diagnosed and followed at the Rheumatology Clinic of the Children's Hospital of Brasilia (Brasilia, Brazil). PARTICIPANTS: This study included 110 children with history of KD and a control group composed of 110 presumably healthy children. INTERVENTIONS: Participants underwent anti-transglutaminase and anti-endomysial antibodies tests and genetic typing for the presence of CD predisposing alleles (HLA-DQ2 and DQ8). Jejunal biopsy was performed when necessary, according the European Society of Paediatric Gastroenterology, Hepatology and Nutrition guidelines. RESULTS: Diagnosis of CD was confirmed in one (0.91%) patient with KD by positive serological tests, presence of predisposing alleles and CD typical lesions on duodenal biopsy. All serological tests were negative among the controls. The prevalence of CD predisposing alleles among patients with KD was 29.09%, similar to the prevalence found among controls, 33.64%. CONCLUSION: The detected CD prevalence (0.91%) does not confirm the existence of an association between KD and CD since this prevalence is similar to that found in the general population (≃1%). SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/29444780/The_possible_link_between_coeliac_and_Kawasaki_diseases_in_Brazil:_a_cross_sectional_study_ L2 - http://bmjopen.bmj.com/cgi/pmidlookup?view=long&pmid=29444780 DB - PRIME DP - Unbound Medicine ER -