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Biomedical Potentialities of Taraxacum officinale-based Nanoparticles Biosynthesized Using Methanolic Leaf Extract.
Curr Pharm Biotechnol. 2017; 18(14):1116-1123.CP

Abstract

BACKGROUND

In the present study, the potential of methanolic leaf extract of Taraxacum officinale plant as a function of bio-inspired green synthesis for the fabrication of silver nanoparticles (AgNPs) has been explored.

METHODS

The bio-reduction of aqueous silver nitrate (AgNO3) solution was confirmed by visually detecting the color change from pale yellow to blackish-brown. Maximum absorbance was observed at 420 nm due to the presence of characteristic surface Plasmon resonance of nano silver by UV-visible spectroscopy. The role of various functional groups in the bio-reduction of silver and chemical transformation was verified by Fourier transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX) predict the shape (rocky, flack type, ellipsoidal, etc.), size (68 nm) and elemental composition (Ag as a major constituent) of the biosynthesized AgNPs, respectively.

RESULTS

Transmission electron microscopy (TEM) analysis further corroborated the morphology of the AgNPs. Color mapping and atomic force microscopy (AFM) confirmed the nano-sized topography. The dynamic light scattering (DLS) showed the charge, stability, and size of the AgNPs. The generated AgNPs presented potential antibacterial activities against Gram-positive and Gram-negative bacterial strains including Staphylococcus aureus, Escherichia coli, and Haemophilus influenzae. The biosynthesized AgNPs also showed antiproliferative activity against MCF-7 breast cancer cell line in a dosedependent manner.

CONCLUSION

In conclusion, results clearly indicate that biosynthesized AgNPs could be used as effective nano drug for treating infectious diseases caused by multidrug resistant bacterial strains in the near future.

Authors+Show Affiliations

The School of Chemistry & Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China.State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.The School of Chemistry & Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China.Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey, N.L., CP 64849, Mexico.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29446732

Citation

Rasheed, Tahir, et al. "Biomedical Potentialities of Taraxacum Officinale-based Nanoparticles Biosynthesized Using Methanolic Leaf Extract." Current Pharmaceutical Biotechnology, vol. 18, no. 14, 2017, pp. 1116-1123.
Rasheed T, Bilal M, Li C, et al. Biomedical Potentialities of Taraxacum officinale-based Nanoparticles Biosynthesized Using Methanolic Leaf Extract. Curr Pharm Biotechnol. 2017;18(14):1116-1123.
Rasheed, T., Bilal, M., Li, C., & Iqbal, H. M. N. (2017). Biomedical Potentialities of Taraxacum officinale-based Nanoparticles Biosynthesized Using Methanolic Leaf Extract. Current Pharmaceutical Biotechnology, 18(14), 1116-1123. https://doi.org/10.2174/1389201019666180214145421
Rasheed T, et al. Biomedical Potentialities of Taraxacum Officinale-based Nanoparticles Biosynthesized Using Methanolic Leaf Extract. Curr Pharm Biotechnol. 2017;18(14):1116-1123. PubMed PMID: 29446732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomedical Potentialities of Taraxacum officinale-based Nanoparticles Biosynthesized Using Methanolic Leaf Extract. AU - Rasheed,Tahir, AU - Bilal,Muhammad, AU - Li,Chuanlong, AU - Iqbal,Hafiz M N, PY - 2017/09/10/received PY - 2018/01/11/revised PY - 2018/02/09/accepted PY - 2018/2/16/pubmed PY - 2018/8/18/medline PY - 2018/2/16/entrez KW - Antibacterial KW - MCF-7 cell line KW - Taraxacum officinale KW - anti-biofilm KW - characterization KW - nanoparticles. SP - 1116 EP - 1123 JF - Current pharmaceutical biotechnology JO - Curr Pharm Biotechnol VL - 18 IS - 14 N2 - BACKGROUND: In the present study, the potential of methanolic leaf extract of Taraxacum officinale plant as a function of bio-inspired green synthesis for the fabrication of silver nanoparticles (AgNPs) has been explored. METHODS: The bio-reduction of aqueous silver nitrate (AgNO3) solution was confirmed by visually detecting the color change from pale yellow to blackish-brown. Maximum absorbance was observed at 420 nm due to the presence of characteristic surface Plasmon resonance of nano silver by UV-visible spectroscopy. The role of various functional groups in the bio-reduction of silver and chemical transformation was verified by Fourier transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX) predict the shape (rocky, flack type, ellipsoidal, etc.), size (68 nm) and elemental composition (Ag as a major constituent) of the biosynthesized AgNPs, respectively. RESULTS: Transmission electron microscopy (TEM) analysis further corroborated the morphology of the AgNPs. Color mapping and atomic force microscopy (AFM) confirmed the nano-sized topography. The dynamic light scattering (DLS) showed the charge, stability, and size of the AgNPs. The generated AgNPs presented potential antibacterial activities against Gram-positive and Gram-negative bacterial strains including Staphylococcus aureus, Escherichia coli, and Haemophilus influenzae. The biosynthesized AgNPs also showed antiproliferative activity against MCF-7 breast cancer cell line in a dosedependent manner. CONCLUSION: In conclusion, results clearly indicate that biosynthesized AgNPs could be used as effective nano drug for treating infectious diseases caused by multidrug resistant bacterial strains in the near future. SN - 1873-4316 UR - https://www.unboundmedicine.com/medline/citation/29446732/Biomedical_Potentialities_of_Taraxacum_officinale_based_Nanoparticles_Biosynthesized_Using_Methanolic_Leaf_Extract_ L2 - https://www.eurekaselect.com/159848/article DB - PRIME DP - Unbound Medicine ER -