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Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response †.
Nutr Neurosci 2019; 22(11):750-759NN

Abstract

Objective:

We aimed to test the dose-response association of serum 25(OH)D and risk of dementia and Alzheimer's disease (AD).

Methods:

We performed a systematic search of PubMed and Scopus from database inception up to September 2017. Longitudinal cohort studies reporting risk estimates of incident dementia or AD in the general population, and for three or more quantitative categories of serum 25(OH)D were included. Pooled hazard ratios (HRs) were calculated using fixed-effects/random-effects models.

Results:

Seven prospective cohort studies and one retrospective cohort study (total n = 28,354) involving 1953 cases of dementia and 1607 cases of AD were included. The pooled HRs of dementia and AD were 1.09 (95%CI: 0.95, 1.24) and 1.19 (95%CI: 0.96, 1.41) for vitamin D insufficiency (10-20 ng/ml), and 1.33 (95%CI: 1.08, 1.58) and 1.31 (95%CI: 0.98, 1.65) for deficiency (<10 ng/ml), respectively. The lower risk of dementia was observed at serum 25(OH)D of ∼25 ng/ml, whereas the risk of AD decreased continuously along with the increase of serum 25(OH)D up to ∼35 ng/ml.

Conclusion:

Higher levels of serum 25(OH)D was associated with a lower risk of dementia and AD, but we have no conclusive evidence regarding serum 25(OH)D levels of >35 ng/ml.

Authors+Show Affiliations

Food (salt) Safety Research Center, Semnan University of Medical Sciences , Semnan , Iran.Laboratory of Learning and Memory, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences , Semnan , Iran.Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences , Tehran , Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29447107

Citation

Jayedi, Ahmad, et al. "Vitamin D Status and Risk of Dementia and Alzheimer's Disease: a Meta-analysis of Dose-response †." Nutritional Neuroscience, vol. 22, no. 11, 2019, pp. 750-759.
Jayedi A, Rashidy-Pour A, Shab-Bidar S. Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response †. Nutr Neurosci. 2019;22(11):750-759.
Jayedi, A., Rashidy-Pour, A., & Shab-Bidar, S. (2019). Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response †. Nutritional Neuroscience, 22(11), pp. 750-759. doi:10.1080/1028415X.2018.1436639.
Jayedi A, Rashidy-Pour A, Shab-Bidar S. Vitamin D Status and Risk of Dementia and Alzheimer's Disease: a Meta-analysis of Dose-response †. Nutr Neurosci. 2019;22(11):750-759. PubMed PMID: 29447107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response †. AU - Jayedi,Ahmad, AU - Rashidy-Pour,Ali, AU - Shab-Bidar,Sakineh, Y1 - 2018/02/15/ PY - 2018/2/16/pubmed PY - 2018/2/16/medline PY - 2018/2/16/entrez KW - Alzheimer disease KW - Dementia KW - Meta-analysis KW - Vitamin D deficiency SP - 750 EP - 759 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 22 IS - 11 N2 - Objective: We aimed to test the dose-response association of serum 25(OH)D and risk of dementia and Alzheimer's disease (AD). Methods: We performed a systematic search of PubMed and Scopus from database inception up to September 2017. Longitudinal cohort studies reporting risk estimates of incident dementia or AD in the general population, and for three or more quantitative categories of serum 25(OH)D were included. Pooled hazard ratios (HRs) were calculated using fixed-effects/random-effects models. Results: Seven prospective cohort studies and one retrospective cohort study (total n = 28,354) involving 1953 cases of dementia and 1607 cases of AD were included. The pooled HRs of dementia and AD were 1.09 (95%CI: 0.95, 1.24) and 1.19 (95%CI: 0.96, 1.41) for vitamin D insufficiency (10-20 ng/ml), and 1.33 (95%CI: 1.08, 1.58) and 1.31 (95%CI: 0.98, 1.65) for deficiency (<10 ng/ml), respectively. The lower risk of dementia was observed at serum 25(OH)D of ∼25 ng/ml, whereas the risk of AD decreased continuously along with the increase of serum 25(OH)D up to ∼35 ng/ml. Conclusion: Higher levels of serum 25(OH)D was associated with a lower risk of dementia and AD, but we have no conclusive evidence regarding serum 25(OH)D levels of >35 ng/ml. SN - 1476-8305 UR - https://www.unboundmedicine.com/medline/citation/29447107/Vitamin_D_status_and_risk_of_dementia_and_Alzheimer's_disease:_A_meta_analysis_of_dose_response_ L2 - http://www.tandfonline.com/doi/full/10.1080/1028415X.2018.1436639 DB - PRIME DP - Unbound Medicine ER -