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Imported endemic mycoses in Spain: Evolution of hospitalized cases, clinical characteristics and correlation with migratory movements, 1997-2014.
PLoS Negl Trop Dis. 2018 02; 12(2):e0006245.PN

Abstract

Endemic mycoses are systemic fungal infections. Histoplasmosis is endemic in all temperate areas of the world; coccidioidomycosis and paracoccidioidomycosis are only present in the American continent. These pathogens are not present in Spain, but in the last years there has been an increase of reported cases due to migration and temporary movements. We obtained from the Spanish hospitals records clinical and demographic data of all hospitalized cases between 1997 and 2014. There were 286 cases of histoplasmosis, 94 of Coccidioidomycosis and 25 of paracoccidioidomycosis. Overall, histoplasmosis was strongly related to HIV infection, as well as with greater morbidity and mortality. For the other mycoses, we did not find any immunosuppressive condition in most of the cases. Although we were not able to obtain data about clinical presentation of all the cases, the most frequently found was pulmonary involvement. We also found a temporal correlation between the Spanish population born in endemic countries and the number of hospitalized cases along this period. This study reflects the importance of imported diseases in non-endemic countries due to migratory movements.

Authors+Show Affiliations

Tropical Medicine Unit, Infectious Diseases Department. PROSICS Barcelona (International Health Program of the Catalan Health Institute), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.Tropical Medicine Unit, Infectious Diseases Department. PROSICS Barcelona (International Health Program of the Catalan Health Institute), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.Tropical Medicine Unit, Infectious Diseases Department. PROSICS Barcelona (International Health Program of the Catalan Health Institute), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.Tropical Medicine Unit, Infectious Diseases Department. PROSICS Barcelona (International Health Program of the Catalan Health Institute), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.Tropical Medicine Unit, Infectious Diseases Department. PROSICS Barcelona (International Health Program of the Catalan Health Institute), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29447170

Citation

Molina-Morant, Daniel, et al. "Imported Endemic Mycoses in Spain: Evolution of Hospitalized Cases, Clinical Characteristics and Correlation With Migratory Movements, 1997-2014." PLoS Neglected Tropical Diseases, vol. 12, no. 2, 2018, pp. e0006245.
Molina-Morant D, Sánchez-Montalvá A, Salvador F, et al. Imported endemic mycoses in Spain: Evolution of hospitalized cases, clinical characteristics and correlation with migratory movements, 1997-2014. PLoS Negl Trop Dis. 2018;12(2):e0006245.
Molina-Morant, D., Sánchez-Montalvá, A., Salvador, F., Sao-Avilés, A., & Molina, I. (2018). Imported endemic mycoses in Spain: Evolution of hospitalized cases, clinical characteristics and correlation with migratory movements, 1997-2014. PLoS Neglected Tropical Diseases, 12(2), e0006245. https://doi.org/10.1371/journal.pntd.0006245
Molina-Morant D, et al. Imported Endemic Mycoses in Spain: Evolution of Hospitalized Cases, Clinical Characteristics and Correlation With Migratory Movements, 1997-2014. PLoS Negl Trop Dis. 2018;12(2):e0006245. PubMed PMID: 29447170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Imported endemic mycoses in Spain: Evolution of hospitalized cases, clinical characteristics and correlation with migratory movements, 1997-2014. AU - Molina-Morant,Daniel, AU - Sánchez-Montalvá,Adrián, AU - Salvador,Fernando, AU - Sao-Avilés,Augusto, AU - Molina,Israel, Y1 - 2018/02/15/ PY - 2017/07/31/received PY - 2018/01/18/accepted PY - 2018/02/28/revised PY - 2018/2/16/pubmed PY - 2018/6/16/medline PY - 2018/2/16/entrez SP - e0006245 EP - e0006245 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 12 IS - 2 N2 - Endemic mycoses are systemic fungal infections. Histoplasmosis is endemic in all temperate areas of the world; coccidioidomycosis and paracoccidioidomycosis are only present in the American continent. These pathogens are not present in Spain, but in the last years there has been an increase of reported cases due to migration and temporary movements. We obtained from the Spanish hospitals records clinical and demographic data of all hospitalized cases between 1997 and 2014. There were 286 cases of histoplasmosis, 94 of Coccidioidomycosis and 25 of paracoccidioidomycosis. Overall, histoplasmosis was strongly related to HIV infection, as well as with greater morbidity and mortality. For the other mycoses, we did not find any immunosuppressive condition in most of the cases. Although we were not able to obtain data about clinical presentation of all the cases, the most frequently found was pulmonary involvement. We also found a temporal correlation between the Spanish population born in endemic countries and the number of hospitalized cases along this period. This study reflects the importance of imported diseases in non-endemic countries due to migratory movements. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/29447170/Imported_endemic_mycoses_in_Spain:_Evolution_of_hospitalized_cases_clinical_characteristics_and_correlation_with_migratory_movements_1997_2014_ L2 - http://dx.plos.org/10.1371/journal.pntd.0006245 DB - PRIME DP - Unbound Medicine ER -