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Impact of Micronutrients on the Immune Response of Animals.
Annu Rev Anim Biosci 2018; 6:227-254AR

Abstract

Vitamins and minerals (micronutrients) play an important role in regulating and shaping an immune response. Deficiencies generally result in inadequate or dysregulated cellular activity and cytokine expression, thereby affecting the immune response. Decreased levels of natural killer, granulocyte, and phagocytic cell activity and T and B cell proliferation and trafficking are associated with inadequate levels of micronutrients, as well as increased susceptibility to various adverse health conditions, including inflammatory disorders, infection, and altered vaccine efficacy. In addition, most studies of micronutrient modulation of immune responses have been done in rodents and humans, thus limiting application to the health and well-being of livestock and companion animals. This exploratory review elucidates the role of vitamins and minerals on immune function and inflammatory responses in animals (pigs, dogs, cats, horses, goats, sheep, and cattle), with reference to rodents and humans.

Authors+Show Affiliations

United States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics & Immunology Laboratory, Beltsville, Maryland 20705-2350, USA; email: harry.dawson@ars.usda.gov.Science & Technology Center, Hills Pet Nutrition Center, Topeka, Kansas 66617, USA.United States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics & Immunology Laboratory, Beltsville, Maryland 20705-2350, USA; email: harry.dawson@ars.usda.gov.United States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics & Immunology Laboratory, Beltsville, Maryland 20705-2350, USA; email: harry.dawson@ars.usda.gov.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29447473

Citation

Smith, Allen D., et al. "Impact of Micronutrients On the Immune Response of Animals." Annual Review of Animal Biosciences, vol. 6, 2018, pp. 227-254.
Smith AD, Panickar KS, Urban JF, et al. Impact of Micronutrients on the Immune Response of Animals. Annu Rev Anim Biosci. 2018;6:227-254.
Smith, A. D., Panickar, K. S., Urban, J. F., & Dawson, H. D. (2018). Impact of Micronutrients on the Immune Response of Animals. Annual Review of Animal Biosciences, 6, pp. 227-254. doi:10.1146/annurev-animal-022516-022914.
Smith AD, et al. Impact of Micronutrients On the Immune Response of Animals. Annu Rev Anim Biosci. 2018 02 15;6:227-254. PubMed PMID: 29447473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Micronutrients on the Immune Response of Animals. AU - Smith,Allen D, AU - Panickar,Kiran S, AU - Urban,Joseph F,Jr AU - Dawson,Harry D, PY - 2018/2/16/entrez PY - 2018/2/16/pubmed PY - 2019/3/22/medline KW - ILC KW - acquired immunity KW - innate immunity KW - innate lymphoid cell KW - microbiome SP - 227 EP - 254 JF - Annual review of animal biosciences JO - Annu Rev Anim Biosci VL - 6 N2 - Vitamins and minerals (micronutrients) play an important role in regulating and shaping an immune response. Deficiencies generally result in inadequate or dysregulated cellular activity and cytokine expression, thereby affecting the immune response. Decreased levels of natural killer, granulocyte, and phagocytic cell activity and T and B cell proliferation and trafficking are associated with inadequate levels of micronutrients, as well as increased susceptibility to various adverse health conditions, including inflammatory disorders, infection, and altered vaccine efficacy. In addition, most studies of micronutrient modulation of immune responses have been done in rodents and humans, thus limiting application to the health and well-being of livestock and companion animals. This exploratory review elucidates the role of vitamins and minerals on immune function and inflammatory responses in animals (pigs, dogs, cats, horses, goats, sheep, and cattle), with reference to rodents and humans. SN - 2165-8110 UR - https://www.unboundmedicine.com/medline/citation/29447473/Impact_of_Micronutrients_on_the_Immune_Response_of_Animals_ L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev-animal-022516-022914?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -