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Serum estrogens and androgens in women with endometrial carcinoma.
Gynecol Oncol. 1986 Oct; 25(2):223-33.GO

Abstract

Fifty-two postmenopausal women with newly diagnosed endometrial carcinoma and 58 postmenopausal age-matched controls were studied concerning serum levels of estrone, total estrone, estradiol, androstenedione, testosterone, dehydroepiandrosterone and its sulphate, sex steroid hormone binding globulin, follicle stimulating hormone, and luteinizing hormone. The patients had a higher mean serum level of estradiol (P = 0.006) and a lower level of follicle stimulating hormone (P = 0.001) than the controls and the significant differences remained after the number of years since the menopause and body index had been taken into account. As the serum levels of steroid hormone binding globulin tended to be lower among patients than among controls (P = 0.084), the difference in the biological effect of estradiol between the two groups was probably greater than the difference in serum concentrations would indicate. No significant difference in the ratio of estrone to androstenedione or in the mean serum level of androstenedione was found between patients and controls. These data support the role of estrogen in the etiology of endometrial carcinoma.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2944804

Citation

Pettersson, B, et al. "Serum Estrogens and Androgens in Women With Endometrial Carcinoma." Gynecologic Oncology, vol. 25, no. 2, 1986, pp. 223-33.
Pettersson B, Bergström R, Johansson ED. Serum estrogens and androgens in women with endometrial carcinoma. Gynecol Oncol. 1986;25(2):223-33.
Pettersson, B., Bergström, R., & Johansson, E. D. (1986). Serum estrogens and androgens in women with endometrial carcinoma. Gynecologic Oncology, 25(2), 223-33.
Pettersson B, Bergström R, Johansson ED. Serum Estrogens and Androgens in Women With Endometrial Carcinoma. Gynecol Oncol. 1986;25(2):223-33. PubMed PMID: 2944804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum estrogens and androgens in women with endometrial carcinoma. AU - Pettersson,B, AU - Bergström,R, AU - Johansson,E D, PY - 1986/10/1/pubmed PY - 1986/10/1/medline PY - 1986/10/1/entrez SP - 223 EP - 33 JF - Gynecologic oncology JO - Gynecol Oncol VL - 25 IS - 2 N2 - Fifty-two postmenopausal women with newly diagnosed endometrial carcinoma and 58 postmenopausal age-matched controls were studied concerning serum levels of estrone, total estrone, estradiol, androstenedione, testosterone, dehydroepiandrosterone and its sulphate, sex steroid hormone binding globulin, follicle stimulating hormone, and luteinizing hormone. The patients had a higher mean serum level of estradiol (P = 0.006) and a lower level of follicle stimulating hormone (P = 0.001) than the controls and the significant differences remained after the number of years since the menopause and body index had been taken into account. As the serum levels of steroid hormone binding globulin tended to be lower among patients than among controls (P = 0.084), the difference in the biological effect of estradiol between the two groups was probably greater than the difference in serum concentrations would indicate. No significant difference in the ratio of estrone to androstenedione or in the mean serum level of androstenedione was found between patients and controls. These data support the role of estrogen in the etiology of endometrial carcinoma. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/2944804/Serum_estrogens_and_androgens_in_women_with_endometrial_carcinoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0090-8258(86)90103-4 DB - PRIME DP - Unbound Medicine ER -