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Tubular Adenoma of the Breast: A Clinicopathologic Study of a Series of 9 Cases.
Clin Med Insights Pathol. 2018; 11:1179555718757499.CM

Abstract

Tubular adenoma of the breast is one of the most rare benign neoplasms, accounting for only 0.13% to 1.7% of all breast benign tumors. Little is known about this rare neoplasm as the current literature offers only some case reports or a few number of small series. The aim of our study is to provide some clinicopathologic features of the breast tubular adenoma. We retrospectively analyzed at our department of pathology all cases of breast tubular adenomas confirmed by immunohistochemistry over a period of 9 years (2009-2017). Nine cases of breast tubular adenoma have been recorded, with an average age of 31.44 years. Five tumors were located at the right side (55.55%), and most cases had suspicious aspects on imaging techniques (6 cases out of 9). The diagnosis has been made on 5 resected specimens (lumpectomy) and on 4 core needle biopsies. The tumor size ranged from 0.9 to 7 cm (mean size of 3.08 cm) and had well-circumscribed margins with elastic consistency. The histopathologic analysis showed a typical pattern of proliferating round and uniform tubules lined by regular epithelial cells surrounded by myoepithelial cells, packed in a small amount of stroma, highlighted by CD34 immunostaining. Tubular adenoma is a rare breast benign neoplasm of young premenopausal women. The radiologic aspects are often worrisome and only the histopathologic analysis can achieve the correct definitive diagnosis by excluding all potential differential diagnoses.

Authors+Show Affiliations

Department of Pathology, Hassan II University Hospital, Fès, Morocco.Department of Pathology, Hassan II University Hospital, Fès, Morocco.Department of Radiology, Hassan II University Hospital, Fès, Morocco.Department of Pathology, Hassan II University Hospital, Fès, Morocco. Faculty of Medicine and Pharmacology, Sidi Mohamed Ben Abdellah University, Fès, Morocco.Department of Pathology, Hassan II University Hospital, Fès, Morocco. Faculty of Medicine and Pharmacology, Sidi Mohamed Ben Abdellah University, Fès, Morocco.Department of Pathology, Hassan II University Hospital, Fès, Morocco. Faculty of Medicine and Pharmacology, Sidi Mohamed Ben Abdellah University, Fès, Morocco.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29449780

Citation

Efared, Boubacar, et al. "Tubular Adenoma of the Breast: a Clinicopathologic Study of a Series of 9 Cases." Clinical Medicine Insights. Pathology, vol. 11, 2018, p. 1179555718757499.
Efared B, Sidibé IS, Abdoulaziz S, et al. Tubular Adenoma of the Breast: A Clinicopathologic Study of a Series of 9 Cases. Clin Med Insights Pathol. 2018;11:1179555718757499.
Efared, B., Sidibé, I. S., Abdoulaziz, S., Hammas, N., Chbani, L., & El Fatemi, H. (2018). Tubular Adenoma of the Breast: A Clinicopathologic Study of a Series of 9 Cases. Clinical Medicine Insights. Pathology, 11, 1179555718757499. https://doi.org/10.1177/1179555718757499
Efared B, et al. Tubular Adenoma of the Breast: a Clinicopathologic Study of a Series of 9 Cases. Clin Med Insights Pathol. 2018;11:1179555718757499. PubMed PMID: 29449780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tubular Adenoma of the Breast: A Clinicopathologic Study of a Series of 9 Cases. AU - Efared,Boubacar, AU - Sidibé,Ibrahim S, AU - Abdoulaziz,Souley, AU - Hammas,Nawal, AU - Chbani,Laila, AU - El Fatemi,Hinde, Y1 - 2018/02/05/ PY - 2017/11/05/received PY - 2018/01/10/accepted PY - 2018/2/17/entrez PY - 2018/2/17/pubmed PY - 2018/2/17/medline KW - Breast KW - pathology KW - tubular adenoma SP - 1179555718757499 EP - 1179555718757499 JF - Clinical medicine insights. Pathology JO - Clin Med Insights Pathol VL - 11 N2 - Tubular adenoma of the breast is one of the most rare benign neoplasms, accounting for only 0.13% to 1.7% of all breast benign tumors. Little is known about this rare neoplasm as the current literature offers only some case reports or a few number of small series. The aim of our study is to provide some clinicopathologic features of the breast tubular adenoma. We retrospectively analyzed at our department of pathology all cases of breast tubular adenomas confirmed by immunohistochemistry over a period of 9 years (2009-2017). Nine cases of breast tubular adenoma have been recorded, with an average age of 31.44 years. Five tumors were located at the right side (55.55%), and most cases had suspicious aspects on imaging techniques (6 cases out of 9). The diagnosis has been made on 5 resected specimens (lumpectomy) and on 4 core needle biopsies. The tumor size ranged from 0.9 to 7 cm (mean size of 3.08 cm) and had well-circumscribed margins with elastic consistency. The histopathologic analysis showed a typical pattern of proliferating round and uniform tubules lined by regular epithelial cells surrounded by myoepithelial cells, packed in a small amount of stroma, highlighted by CD34 immunostaining. Tubular adenoma is a rare breast benign neoplasm of young premenopausal women. The radiologic aspects are often worrisome and only the histopathologic analysis can achieve the correct definitive diagnosis by excluding all potential differential diagnoses. SN - 1179-5557 UR - https://www.unboundmedicine.com/medline/citation/29449780/Tubular_Adenoma_of_the_Breast:_A_Clinicopathologic_Study_of_a_Series_of_9_Cases_ L2 - http://journals.sagepub.com/doi/full/10.1177/1179555718757499?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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